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Associations between cardiorespiratory fitness and the metabolic syndrome in British men

Sandercock, Gavin R; Ingle, Lee; Mellis, Michelle; Brodie, David; Sandercock, Gavin R.

Authors

Gavin R Sandercock

Michelle Mellis

David Brodie

Gavin R. Sandercock



Abstract

Background: Age and body mass index (BMI) are positively associated with the development of the metabolic syndrome (MetS). Cardiorespiratory fitness (CRF) can attenuate BMI-related increases in prevalence of MetS, but the nature of this association across dif-ferent age strata has not been fully investigated. Aim: To identify the association between CRF and MetS prevalence across age-strata (20– 69 years) and determine whether associations are independent of BMI. Methods: CRF was estimated from incremental treadmill exercise in British men attending preventative health screening. Participants were placed in four age strata (20-39, 40-49, 50-59 and 60-69 years) and classified as Fit or Unfit using age-related cut-offs. Pres-ence of MetS was defined using the National Cholesterol Education Program Adult Treatment Panel III criteria. Results: 9 666 asymptomatic men (48.7±8.4 years) were enrolled. The prevalence of MetS was 25.5% in all men, and ranged from 17.1% in 20-39 year olds to 30.6% in 60-69 year olds. Fit men’s likelihood of meeting the criteria for MetS was half (OR=0.51, 95%CI:0.46-0.57) that of unfit men. The likelihood of MetS was 32-53% lower across age strata in Fit, compared with Unfit men. Adjustment for BMI attenuated the association, though it remained significant in men aged 20-49 years. Conclusion: The cardio-metabolic benefits of CRF are independent of BMI particularly in men <50 years. Public health messages should emphasise the important role of CRF alongside weight management for enhancing cardio-metabolic health.

Citation

Ingle, L., Mellis, M., Brodie, D., & Sandercock, G. R. (2017). Associations between cardiorespiratory fitness and the metabolic syndrome in British men. Heart, 103(7), 524-528. https://doi.org/10.1136/heartjnl-2016-310142

Journal Article Type Article
Acceptance Date Oct 14, 2016
Online Publication Date Oct 25, 2016
Publication Date Apr 1, 2017
Deposit Date Oct 17, 2016
Publicly Available Date Oct 25, 2016
Journal Heart
Print ISSN 1355-6037
Electronic ISSN 1468-201X
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 103
Issue 7
Pages 524-528
DOI https://doi.org/10.1136/heartjnl-2016-310142
Keywords Epidemiology; Risk factors; Exercise; Exercise testing
Public URL https://hull-repository.worktribe.com/output/444199
Publisher URL http://heart.bmj.com/content/early/2016/10/25/heartjnl-2016-310142
Additional Information Authors' accepted manuscript of article: Ingle L, Mellis M, Brodie D, et al. Associations between cardiorespiratory fitness and the metabolic syndrome in British men. Heart 2017;103:524-528.

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