D. Price
Age-related delay in visual and auditory evoked responses is mediated by white-and grey-matter differences
Price, D.; Tyler, L. K.; Neto Henriques, R.; Campbell, K. L.; Williams, N.; Treder, M. S.; Taylor, J. R.; Henson, R. N.A.; Brayne, Carol; Bullmore, Edward T.; Calder, Andrew C.; Cusack, Rhodri; Dalgleish, Tim; Duncan, John; Matthews, Fiona E.; Marslen-Wilson, William D.; Rowe, James B.; Shafto, Meredith A.; Cheung, Teresa; Davis, Simon; Geerligs, Linda; Kievit, Rogier; McCarrey, Anna; Mustafa, Abdur; Samu, David; Tsvetanov, Kamen A.; van Belle, Janna; Bates, Lauren; Emery, Tina; Erzinglioglu, Sharon; Gadie, Andrew; Gerbase, Sofia; Georgieva, Stanimira; Hanley, Claire; Parkin, Beth; Troy, David; Auer, Tibor; Correia, Marta; Gao, Lu; Green, Emma; Allen, Jodie; Amery, Gillian; Amunts, Liana; Barcroft, Anne; Castle, Amanda; Dias, Cheryl; Dowrick, Jonathan; Fair, Melissa; Fisher, Hayley; Goulding, Anna; Grewal, Adarsh; Hale, Geoff; Hilton, Andrew; Johnson, Frances; Johnston, Patricia; Kavanagh-Williamson, Thea; Kwasniewska, Magdalena; McMinn, Alison; Norman, Kim; Penrose, Jessica; Roby, Fio...
Authors
L. K. Tyler
R. Neto Henriques
K. L. Campbell
N. Williams
M. S. Treder
J. R. Taylor
R. N.A. Henson
Carol Brayne
Edward T. Bullmore
Andrew C. Calder
Rhodri Cusack
Tim Dalgleish
John Duncan
Professor Fiona Matthews F.Matthews@hull.ac.uk
Pro-Vice-Chancellor Research and Enterprise
William D. Marslen-Wilson
James B. Rowe
Meredith A. Shafto
Teresa Cheung
Simon Davis
Linda Geerligs
Rogier Kievit
Anna McCarrey
Abdur Mustafa
David Samu
Kamen A. Tsvetanov
Janna van Belle
Lauren Bates
Tina Emery
Sharon Erzinglioglu
Andrew Gadie
Sofia Gerbase
Stanimira Georgieva
Claire Hanley
Beth Parkin
David Troy
Tibor Auer
Marta Correia
Lu Gao
Emma Green
Jodie Allen
Gillian Amery
Liana Amunts
Anne Barcroft
Amanda Castle
Cheryl Dias
Jonathan Dowrick
Melissa Fair
Hayley Fisher
Anna Goulding
Adarsh Grewal
Geoff Hale
Andrew Hilton
Frances Johnson
Patricia Johnston
Thea Kavanagh-Williamson
Magdalena Kwasniewska
Alison McMinn
Kim Norman
Jessica Penrose
Fiona Roby
Diane Rowland
John Sargeant
Maggie Squire
Beth Stevens
Aldabra Stoddart
Cheryl Stone
Tracy Thompson
Ozlem Yazlik
Dan Barnes
Marie Dixon
Jaya Hillman
Joanne Mitchell
Laura Villis
Abstract
Slowing is a common feature of ageing, yet a direct relationship between neural slowing and brain atrophy is yet to be established in healthy humans. We combine magnetoencephalo-graphic (MEG) measures of neural processing speed with magnetic resonance imaging (MRI) measures of white and grey matter in a large population-derived cohort to investigate the relationship between age-related structural differences and visual evoked field (VEF) and auditory evoked field (AEF) delay across two different tasks. Here we use a novel technique to show that VEFs exhibit a constant delay, whereas AEFs exhibit delay that accumulates over time. White-matter (WM) microstructure in the optic radiation partially mediates visual delay, suggesting increased transmission time, whereas grey matter (GM) in auditory cortex partially mediates auditory delay, suggesting less efficient local processing. Our results demonstrate that age has dissociable effects on neural processing speed, and that these effects relate to different types of brain atrophy.
Citation
Price, D., Tyler, L. K., Neto Henriques, R., Campbell, K. L., Williams, N., Treder, M. S., …Villis, L. (2017). Age-related delay in visual and auditory evoked responses is mediated by white-and grey-matter differences. Nature communications, 8, https://doi.org/10.1038/ncomms15671
Journal Article Type | Article |
---|---|
Publication Date | Jan 1, 2017 |
Deposit Date | Dec 8, 2023 |
Journal | Nature Communications |
Electronic ISSN | 2041-1723 |
Publisher | Nature Publishing Group |
Volume | 8 |
DOI | https://doi.org/10.1038/ncomms15671 |
Public URL | https://hull-repository.worktribe.com/output/4453302 |
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