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Age-related delay in visual and auditory evoked responses is mediated by white-and grey-matter differences

Price, D.; Tyler, L. K.; Neto Henriques, R.; Campbell, K. L.; Williams, N.; Treder, M. S.; Taylor, J. R.; Henson, R. N.A.; Brayne, Carol; Bullmore, Edward T.; Calder, Andrew C.; Cusack, Rhodri; Dalgleish, Tim; Duncan, John; Matthews, Fiona E.; Marslen-Wilson, William D.; Rowe, James B.; Shafto, Meredith A.; Cheung, Teresa; Davis, Simon; Geerligs, Linda; Kievit, Rogier; McCarrey, Anna; Mustafa, Abdur; Samu, David; Tsvetanov, Kamen A.; van Belle, Janna; Bates, Lauren; Emery, Tina; Erzinglioglu, Sharon; Gadie, Andrew; Gerbase, Sofia; Georgieva, Stanimira; Hanley, Claire; Parkin, Beth; Troy, David; Auer, Tibor; Correia, Marta; Gao, Lu; Green, Emma; Allen, Jodie; Amery, Gillian; Amunts, Liana; Barcroft, Anne; Castle, Amanda; Dias, Cheryl; Dowrick, Jonathan; Fair, Melissa; Fisher, Hayley; Goulding, Anna; Grewal, Adarsh; Hale, Geoff; Hilton, Andrew; Johnson, Frances; Johnston, Patricia; Kavanagh-Williamson, Thea; Kwasniewska, Magdalena; McMinn, Alison; Norman, Kim; Penrose, Jessica; Roby, Fio...

Authors

D. Price

L. K. Tyler

R. Neto Henriques

K. L. Campbell

N. Williams

M. S. Treder

J. R. Taylor

R. N.A. Henson

Carol Brayne

Edward T. Bullmore

Andrew C. Calder

Rhodri Cusack

Tim Dalgleish

John Duncan

William D. Marslen-Wilson

James B. Rowe

Meredith A. Shafto

Teresa Cheung

Simon Davis

Linda Geerligs

Rogier Kievit

Anna McCarrey

Abdur Mustafa

David Samu

Kamen A. Tsvetanov

Janna van Belle

Lauren Bates

Tina Emery

Sharon Erzinglioglu

Andrew Gadie

Sofia Gerbase

Stanimira Georgieva

Claire Hanley

Beth Parkin

David Troy

Tibor Auer

Marta Correia

Lu Gao

Emma Green

Jodie Allen

Gillian Amery

Liana Amunts

Anne Barcroft

Amanda Castle

Cheryl Dias

Jonathan Dowrick

Melissa Fair

Hayley Fisher

Anna Goulding

Adarsh Grewal

Geoff Hale

Andrew Hilton

Frances Johnson

Patricia Johnston

Thea Kavanagh-Williamson

Magdalena Kwasniewska

Alison McMinn

Kim Norman

Jessica Penrose

Fiona Roby

Diane Rowland

John Sargeant

Maggie Squire

Beth Stevens

Aldabra Stoddart

Cheryl Stone

Tracy Thompson

Ozlem Yazlik

Dan Barnes

Marie Dixon

Jaya Hillman

Joanne Mitchell

Laura Villis



Abstract

Slowing is a common feature of ageing, yet a direct relationship between neural slowing and brain atrophy is yet to be established in healthy humans. We combine magnetoencephalo-graphic (MEG) measures of neural processing speed with magnetic resonance imaging (MRI) measures of white and grey matter in a large population-derived cohort to investigate the relationship between age-related structural differences and visual evoked field (VEF) and auditory evoked field (AEF) delay across two different tasks. Here we use a novel technique to show that VEFs exhibit a constant delay, whereas AEFs exhibit delay that accumulates over time. White-matter (WM) microstructure in the optic radiation partially mediates visual delay, suggesting increased transmission time, whereas grey matter (GM) in auditory cortex partially mediates auditory delay, suggesting less efficient local processing. Our results demonstrate that age has dissociable effects on neural processing speed, and that these effects relate to different types of brain atrophy.

Citation

Price, D., Tyler, L. K., Neto Henriques, R., Campbell, K. L., Williams, N., Treder, M. S., …Villis, L. (2017). Age-related delay in visual and auditory evoked responses is mediated by white-and grey-matter differences. Nature communications, 8, https://doi.org/10.1038/ncomms15671

Journal Article Type Article
Publication Date Jan 1, 2017
Deposit Date Dec 8, 2023
Journal Nature Communications
Electronic ISSN 2041-1723
Publisher Nature Publishing Group
Volume 8
DOI https://doi.org/10.1038/ncomms15671
Public URL https://hull-repository.worktribe.com/output/4453302