Noham Wolpe
Ageing increases reliance on sensorimotor prediction through structural and functional differences in frontostriatal circuits
Wolpe, Noham; Ingram, James N.; Tsvetanov, Kamen A.; Geerligs, Linda; Kievit, Rogier A.; Henson, Richard N.; Wolpert, Daniel M.; Rowe, James B.; Tyler, Lorraine K.; Brayne, Carol; Bullmore, Edward; Calder, Andrew; Cusack, Rhodri; Dalgleish, Tim; Duncan, John; Matthews, Fiona E.; Marslen-Wilson, William; Shafto, Meredith A.; Campbell, Karen; Cheung, Teresa; Davis, Simon; McCarrey, Anna; Mustafa, Abdur; Price, Darren; Samu, David; Taylor, Jason R.; Treder, Matthias; van Belle, Janna; Williams, Nitin; Bates, Lauren; Emery, Tina; Erzinclioglu, Sharon; Gadie, Andrew; Gerbase, Sofia; Georgieva, Stanimira; Hanley, Claire; Parkin, Beth; Troy, David; Auer, Tibor; Correia, Marta; Gao, Lu; Green, Emma; Henriques, Rafael; Allen, Jodie; Amery, Gillian; Amunts, Liana; Barcroft, Anne; Castle, Amanda; Dias, Cheryl; Dowrick, Jonathan; Fair, Melissa; Fisher, Hayley; Goulding, Anna; Grewal, Adarsh; Hale, Geoff; Hilton, Andrew; Johnson, Frances; Johnston, Patricia; Kavanagh-Williamson, Thea; Kwasniewska,...
Authors
James N. Ingram
Kamen A. Tsvetanov
Linda Geerligs
Rogier A. Kievit
Richard N. Henson
Daniel M. Wolpert
James B. Rowe
Lorraine K. Tyler
Carol Brayne
Edward Bullmore
Andrew Calder
Rhodri Cusack
Tim Dalgleish
John Duncan
Professor Fiona Matthews F.Matthews@hull.ac.uk
Pro-Vice-Chancellor Research and Enterprise
William Marslen-Wilson
Meredith A. Shafto
Karen Campbell
Teresa Cheung
Simon Davis
Anna McCarrey
Abdur Mustafa
Darren Price
David Samu
Jason R. Taylor
Matthias Treder
Janna van Belle
Nitin Williams
Lauren Bates
Tina Emery
Sharon Erzinclioglu
Andrew Gadie
Sofia Gerbase
Stanimira Georgieva
Claire Hanley
Beth Parkin
David Troy
Tibor Auer
Marta Correia
Lu Gao
Emma Green
Rafael Henriques
Jodie Allen
Gillian Amery
Liana Amunts
Anne Barcroft
Amanda Castle
Cheryl Dias
Jonathan Dowrick
Melissa Fair
Hayley Fisher
Anna Goulding
Adarsh Grewal
Geoff Hale
Andrew Hilton
Frances Johnson
Patricia Johnston
Thea Kavanagh-Williamson
Magdalena Kwasniewska
Alison McMinn
Kim Norman
Jessica Penrose
Fiona Roby
Diane Rowland
John Sargeant
Maggie Squire
Beth Stevens
Aldabra Stoddart
Cheryl Stone
Tracy Thompson
Ozlem Yazlik
Dan Barnes
Marie Dixon
Jaya Hillman
Joanne Mitchell
Laura Villis
Abstract
The control of voluntary movement changes markedly with age. A critical component of motor control is the integration of sensory information with predictions of the consequences of action, arising from internal models of movement. This leads to sensorimotor attenuation - a reduction in the perceived intensity of sensations from self-generated compared with external actions. Here we show that sensorimotor attenuation occurs in 98% of adults in a population-based cohort (n=325; 18-88 years; the Cambridge Centre for Ageing and Neuroscience). Importantly, attenuation increases with age, in proportion to reduced sensory sensitivity. This effect is associated with differences in the structure and functional connectivity of the pre-supplementary motor area (pre-SMA), assessed with magnetic resonance imaging. The results suggest that ageing alters the balance between the sensorium and predictive models, mediated by the pre-SMA and its connectivity in frontostriatal circuits. This shift may contribute to the motor and cognitive changes observed with age.
Citation
Wolpe, N., Ingram, J. N., Tsvetanov, K. A., Geerligs, L., Kievit, R. A., Henson, R. N., Wolpert, D. M., Rowe, J. B., Tyler, L. K., Brayne, C., Bullmore, E., Calder, A., Cusack, R., Dalgleish, T., Duncan, J., Matthews, F. E., Marslen-Wilson, W., Shafto, M. A., Campbell, K., Cheung, T., …Villis, L. (2016). Ageing increases reliance on sensorimotor prediction through structural and functional differences in frontostriatal circuits. Nature communications, 7, https://doi.org/10.1038/ncomms13034
Journal Article Type | Article |
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Publication Date | Oct 3, 2016 |
Deposit Date | Dec 8, 2023 |
Journal | Nature Communications |
Electronic ISSN | 2041-1723 |
Publisher | Nature Publishing Group |
Volume | 7 |
DOI | https://doi.org/10.1038/ncomms13034 |
Public URL | https://hull-repository.worktribe.com/output/4453393 |
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