Richard N. Henson
Multiple determinants of lifespan memory differences
Henson, Richard N.; Campbell, Karen L.; Davis, Simon W.; Taylor, Jason R.; Emery, Tina; Erzinclioglu, Sharon; Kievit, Rogier A.; Tyler, Lorraine K.; Brayne, Carol; Bullmore, Edward T.; Calder, Andrew C.; Cusack, Rhodri; Dalgleish, Tim; Duncan, John; Matthews, Fiona E.; Marslen-Wilson, William D.; Rowe, James B.; Shafto, Meredith A.; Cheung, Teresa; Geerligs, Linda; McCarrey, Anna; Mustafa, Abdur; Price, Darren; Samu, David; Treder, Matthias; Tsvetanov, Kamen A.; Van Belle, Janna; Williams, Nitin; Bates, Lauren; Gadie, Andrew; Gerbase, Sofia; Georgieva, Stanimira; Hanley, Claire; Parkin, Beth; Troy, David; Auer, Tibor; Correia, Marta; Gao, Lu; Green, Emma; Henriques, Rafael; Allen, Jodie; Amery, Gillian; Amunts, Liana; Barcroft, Anne; Castle, Amanda; Dias, Cheryl; Dowrick, Jonathan; Fair, Melissa; Fisher, Hayley; Goulding, Anna; Grewal, Adarsh; Hale, Geoff; Hilton, Andrew; Johnson, Frances; Johnston, Patricia; Kavanagh-Williamson, Thea; Kwasniewska, Magdalena; McMinn, Alison; Norman, Ki...
Authors
Karen L. Campbell
Simon W. Davis
Jason R. Taylor
Tina Emery
Sharon Erzinclioglu
Rogier A. Kievit
Lorraine K. Tyler
Carol Brayne
Edward T. Bullmore
Andrew C. Calder
Rhodri Cusack
Tim Dalgleish
John Duncan
Professor Fiona Matthews F.Matthews@hull.ac.uk
Pro-Vice-Chancellor Research and Enterprise
William D. Marslen-Wilson
James B. Rowe
Meredith A. Shafto
Teresa Cheung
Linda Geerligs
Anna McCarrey
Abdur Mustafa
Darren Price
David Samu
Matthias Treder
Kamen A. Tsvetanov
Janna Van Belle
Nitin Williams
Lauren Bates
Andrew Gadie
Sofia Gerbase
Stanimira Georgieva
Claire Hanley
Beth Parkin
David Troy
Tibor Auer
Marta Correia
Lu Gao
Emma Green
Rafael Henriques
Jodie Allen
Gillian Amery
Liana Amunts
Anne Barcroft
Amanda Castle
Cheryl Dias
Jonathan Dowrick
Melissa Fair
Hayley Fisher
Anna Goulding
Adarsh Grewal
Geoff Hale
Andrew Hilton
Frances Johnson
Patricia Johnston
Thea Kavanagh-Williamson
Magdalena Kwasniewska
Alison McMinn
Kim Norman
Jessica Penrose
Fiona Roby
Diane Rowland
John Sargeant
Maggie Squire
Beth Stevens
Aldabra Stoddart
Cheryl Stone
Tracy Thompson
Ozlem Yazlik
Dan Barnes
Marie Dixon
Jaya Hillman
Joanne Mitchell
Laura Villis
Abstract
Memory problems are among the most common complaints as people grow older. Using structural equation modeling of commensurate scores of anterograde memory from a large (N = 315), population-derived sample (www.cam-can.org), we provide evidence for three memory factors that are supported by distinct brain regions and show differential sensitivity to age. Associative memory and item memory are dramatically affected by age, even after adjusting for education level and fluid intelligence, whereas visual priming is not. Associative memory and item memory are differentially affected by emotional valence, and the age-related decline in associative memory is faster for negative than for positive or neutral stimuli. Gray-matter volume in the hippocampus, parahippocampus and fusiform cortex, and a white-matter index for the fornix, uncinate fasciculus and inferior longitudinal fasciculus, show differential contributions to the three memory factors. Together, these data demonstrate the extent to which differential ageing of the brain leads to differential patterns of memory loss.
Citation
Henson, R. N., Campbell, K. L., Davis, S. W., Taylor, J. R., Emery, T., Erzinclioglu, S., …Villis, L. (2016). Multiple determinants of lifespan memory differences. Scientific reports, 6, https://doi.org/10.1038/srep32527
Journal Article Type | Article |
---|---|
Publication Date | Sep 7, 2016 |
Deposit Date | Dec 8, 2023 |
Journal | Scientific Reports |
Print ISSN | 2045-2322 |
Electronic ISSN | 2045-2322 |
Publisher | Nature Publishing Group |
Volume | 6 |
DOI | https://doi.org/10.1038/srep32527 |
Public URL | https://hull-repository.worktribe.com/output/4453471 |
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