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Vascular health, diabetes, APOE and dementia: The aging, demographics, and memory study

Llewellyn, David J.; Lang, Iain A.; Matthews, Fiona E.; Plassman, Brenda L.; Rogers, Mary Am; Morgenstern, Lewis B.; Fisher, Gwenith G.; Kabeto, Mohammed U.; Langa, Kenneth M.

Authors

David J. Llewellyn

Iain A. Lang

Brenda L. Plassman

Mary Am Rogers

Lewis B. Morgenstern

Gwenith G. Fisher

Mohammed U. Kabeto

Kenneth M. Langa



Abstract

Introduction. Evidence from clinical samples and geographically limited population studies suggests that vascular health, diabetes and apolipoprotein 4 (APOE) are associated with dementia. Methods. A population-based sample of 856 individuals aged 71 years or older from all contiguous regions of the United States received an extensive in-home clinical and neuropsychological assessment in 2001-2003. The relation of hypertension, diabetes, heart disease, stroke, medication usage, and APOE 4 to dementia was modelled using adjusted multivariable logistic regression. Results. Treated stroke (odds ratio [OR] 3.8, 95% confidence interval [CI] 2.0, 7.2), untreated stroke (OR 3.5, 95% CI 1.7, 7.3), and APOE 4 (OR 2.8, 95% CI 1.7, 4.5) all increased the odds of dementia. Treated hypertension was associated with lower odds of dementia (OR 0.5, 95% CI 0.3, 1.0). Diabetes and heart disease were not significantly associated with dementia. A significant interaction was observed between APOE 4 and stroke (P = 0.001). Conclusions. Data from the first dementia study that is representative of the United States population suggest that stroke, the APOE 4 allele and their interaction are strongly associated with dementia. © 2010 Llewellyn et al.; licensee BioMed Central Ltd.

Citation

Llewellyn, D. J., Lang, I. A., Matthews, F. E., Plassman, B. L., Rogers, M. A., Morgenstern, L. B., …Langa, K. M. (2010). Vascular health, diabetes, APOE and dementia: The aging, demographics, and memory study. Alzheimer's Research and Therapy, 2(3), https://doi.org/10.1186/alzrt43

Journal Article Type Article
Publication Date Aug 18, 2010
Deposit Date Dec 8, 2023
Journal Alzheimer's Research and Therapy
Electronic ISSN 1758-9193
Publisher BioMed Central
Volume 2
Issue 3
DOI https://doi.org/10.1186/alzrt43
Public URL https://hull-repository.worktribe.com/output/4455021