David J. Llewellyn
Vascular health, diabetes, APOE and dementia: The aging, demographics, and memory study
Llewellyn, David J.; Lang, Iain A.; Matthews, Fiona E.; Plassman, Brenda L.; Rogers, Mary Am; Morgenstern, Lewis B.; Fisher, Gwenith G.; Kabeto, Mohammed U.; Langa, Kenneth M.
Authors
Iain A. Lang
Professor Fiona Matthews F.Matthews@hull.ac.uk
Pro-Vice-Chancellor Research and Enterprise
Brenda L. Plassman
Mary Am Rogers
Lewis B. Morgenstern
Gwenith G. Fisher
Mohammed U. Kabeto
Kenneth M. Langa
Abstract
Introduction. Evidence from clinical samples and geographically limited population studies suggests that vascular health, diabetes and apolipoprotein 4 (APOE) are associated with dementia. Methods. A population-based sample of 856 individuals aged 71 years or older from all contiguous regions of the United States received an extensive in-home clinical and neuropsychological assessment in 2001-2003. The relation of hypertension, diabetes, heart disease, stroke, medication usage, and APOE 4 to dementia was modelled using adjusted multivariable logistic regression. Results. Treated stroke (odds ratio [OR] 3.8, 95% confidence interval [CI] 2.0, 7.2), untreated stroke (OR 3.5, 95% CI 1.7, 7.3), and APOE 4 (OR 2.8, 95% CI 1.7, 4.5) all increased the odds of dementia. Treated hypertension was associated with lower odds of dementia (OR 0.5, 95% CI 0.3, 1.0). Diabetes and heart disease were not significantly associated with dementia. A significant interaction was observed between APOE 4 and stroke (P = 0.001). Conclusions. Data from the first dementia study that is representative of the United States population suggest that stroke, the APOE 4 allele and their interaction are strongly associated with dementia. © 2010 Llewellyn et al.; licensee BioMed Central Ltd.
Citation
Llewellyn, D. J., Lang, I. A., Matthews, F. E., Plassman, B. L., Rogers, M. A., Morgenstern, L. B., …Langa, K. M. (2010). Vascular health, diabetes, APOE and dementia: The aging, demographics, and memory study. Alzheimer's Research and Therapy, 2(3), https://doi.org/10.1186/alzrt43
Journal Article Type | Article |
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Publication Date | Aug 18, 2010 |
Deposit Date | Dec 8, 2023 |
Journal | Alzheimer's Research and Therapy |
Electronic ISSN | 1758-9193 |
Publisher | BioMed Central |
Volume | 2 |
Issue | 3 |
DOI | https://doi.org/10.1186/alzrt43 |
Public URL | https://hull-repository.worktribe.com/output/4455021 |
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