How β cells can smell insulin fragments

Ardestani, Amin; Maedler, Kathrin

Abstract

In this issue of Cell Metabolism, Cheng et al. identify olfactory receptor Olfr109 in β cells with increased expression in islets from mouse models of obesity and type 1 and type 2 diabetes. Binding of a small insulin fragment to Olfr109 fosters islet inflammation, β cell failure, and diabetes progression.

Citation

Ardestani, A., & Maedler, K. (2022). How β cells can smell insulin fragments. Cell Metabolism, 34(2), 189-191. https://doi.org/10.1016/j.cmet.2022.01.003

• Journal Article Type: Note
• Acceptance Date: Jan 16, 2022
• Online Publication Date: Feb 1, 2022
• Publication Date: Feb 1, 2022
• Deposit Date: Jan 3, 2024
• Journal: Cell metabolism
• Print ISSN: 1550-4131
• Electronic ISSN: 1932-7420
• Publisher: Cell Press
• Peer Reviewed: Peer Reviewed
• Volume: 34
• Issue: 2
• Pages: 189-191
• DOI: https://doi.org/10.1016/j.cmet.2022.01.003
• Public URL: https://hull-repository.worktribe.com/output/4461482