Hippo STK kinases drive metabolic derangement

Maedler, Kathrin; Ardestani, Amin

Abstract

Obesity is associated with mitochondrial dysfunction and chronic metabolic derailment. Cho et al. report that elevated adipose expression of the Hippo kinases STK3 and STK4 (STK3/4) in obesity and type 2 diabetes decreases the mass and oxidative capacity of adipocyte mitochondria. Genetic or pharmacological inhibition of STK3/4 restores mitochondrial mass and function in adipocytes and improves glucose homeostasis in mice with diet-induced obesity. These findings support STK3/4 as new targets for obesity-related diseases.

Citation

Maedler, K., & Ardestani, A. (2021). Hippo STK kinases drive metabolic derangement. Nature Metabolism, 3(3), 295-296. https://doi.org/10.1038/s42255-021-00370-2

• Journal Article Type: Article
• Acceptance Date: Feb 16, 2021
• Online Publication Date: Mar 23, 2021
• Publication Date: Mar 1, 2021
• Deposit Date: Jan 4, 2024
• Journal: Nature Metabolism
• Electronic ISSN: 2522-5812
• Publisher: Nature Research
• Peer Reviewed: Peer Reviewed
• Volume: 3
• Issue: 3
• Pages: 295-296
• DOI: https://doi.org/10.1038/s42255-021-00370-2
• Keywords: Fat metabolism; Mitochondria; Mitophagy; Obesity; Type 2 diabetes
• Public URL: https://hull-repository.worktribe.com/output/4461567