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Multiple myeloma: routes to diagnosis, clinical characteristics and survival - findings from a UK population-based study

Howell, Debra; Smith, Alexandra; Appleton, Simon; Bagguley, Timothy; Macleod, Una; Cook, Gordon; Patmore, Russell; Roman, Eve

Authors

Debra Howell

Alexandra Smith

Simon Appleton

Timothy Bagguley

Gordon Cook

Russell Patmore

Eve Roman



Abstract

Prompt cancer diagnosis may align UK survival with European averages. We examined the impact of route to diagnosis on survival for multiple myeloma patients diagnosed 2012–2013 using data from our population-based patient cohort that links to national death notifications and collects details on treatment and response (n = 441). Emergency presentation was associated with advanced disease and poorer outcomes, and was the commonest route to diagnosis (28·1%) followed by General Practitioner urgent (19·0%) and two-week wait (17·2%) referrals. CRAB (elevated Calcium, Renal failure, Anaemia, Bone lesions) distribution varied by route (P < 0·001), with patients with emergency presentations most likely to have ≥2 features and significantly worse survival (log-rank test χ2 = 13·8, P = 0·0002).

Citation

Howell, D., Smith, A., Appleton, S., Bagguley, T., Macleod, U., Cook, G., …Roman, E. (2017). Multiple myeloma: routes to diagnosis, clinical characteristics and survival - findings from a UK population-based study. British journal of haematology, 177(1), 67-71 . https://doi.org/10.1111/bjh.14513

Journal Article Type Article
Acceptance Date Nov 3, 2016
Online Publication Date Feb 1, 2017
Publication Date Apr 1, 2017
Deposit Date Feb 6, 2017
Publicly Available Date Feb 6, 2017
Journal British journal of haematology
Print ISSN 0007-1048
Electronic ISSN 1365-2141
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 177
Issue 1
Pages 67-71
DOI https://doi.org/10.1111/bjh.14513
Keywords Multiple myeloma; Route to diagnosis; Clinical characteristics; Survival; Emergency presentation
Public URL https://hull-repository.worktribe.com/output/447817
Publisher URL http://onlinelibrary.wiley.com/doi/10.1111/bjh.14513/full
Copyright Statement © 2017 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Additional Information Copy of article: Howell, D., Smith, A., Appleton, S., Bagguley, T., Macleod, U., Cook, G., Patmore, R. and Roman, E. (2017), Multiple myeloma: routes to diagnosis, clinical characteristics and survival – findings from a UK population-based study. Br J Haematol, 177: 67–71. doi:10.1111/bjh.14513

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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/

Copyright Statement
© 2017 The Authors. British Journal of Haematology published by John Wiley & Sons Ltd.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.





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