Multiple myeloma: routes to diagnosis, clinical characteristics and survival - findings from a UK population-based study

Howell, Debra; Smith, Alexandra; Appleton, Simon; Bagguley, Timothy; Macleod, Una; Cook, Gordon; Patmore, Russell; Roman, Eve

Abstract

Prompt cancer diagnosis may align UK survival with European averages. We examined the impact of route to diagnosis on survival for multiple myeloma patients diagnosed 2012–2013 using data from our population-based patient cohort that links to national death notifications and collects details on treatment and response (n = 441). Emergency presentation was associated with advanced disease and poorer outcomes, and was the commonest route to diagnosis (28·1%) followed by General Practitioner urgent (19·0%) and two-week wait (17·2%) referrals. CRAB (elevated Calcium, Renal failure, Anaemia, Bone lesions) distribution varied by route (P < 0·001), with patients with emergency presentations most likely to have ≥2 features and significantly worse survival (log-rank test χ2 = 13·8, P = 0·0002).

Citation

Howell, D., Smith, A., Appleton, S., Bagguley, T., Macleod, U., Cook, G., Patmore, R., & Roman, E. (2017). Multiple myeloma: routes to diagnosis, clinical characteristics and survival - findings from a UK population-based study. British journal of haematology, 177(1), 67-71. https://doi.org/10.1111/bjh.14513

• Journal Article Type: Article
• Acceptance Date: Nov 3, 2016
• Online Publication Date: Feb 1, 2017
• Publication Date: Apr 1, 2017
• Deposit Date: Feb 6, 2017
• Publicly Available Date: Feb 6, 2017
• Journal: British journal of haematology
• Print ISSN: 0007-1048
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 177
• Issue: 1
• Pages: 67-71
• DOI: https://doi.org/10.1111/bjh.14513
• Keywords: Multiple myeloma; Route to diagnosis; Clinical characteristics; Survival; Emergency presentation
• Public URL: https://hull-repository.worktribe.com/output/447817
• Publisher URL: http://onlinelibrary.wiley.com/doi/10.1111/bjh.14513/full
• Additional Information: Copy of article: Howell, D., Smith, A., Appleton, S., Bagguley, T., Macleod, U., Cook, G., Patmore, R. and Roman, E. (2017), Multiple myeloma: routes to diagnosis, clinical characteristics and survival – findings from a UK population-based study. Br J Haematol, 177: 67–71. doi:10.1111/bjh.14513
• Contract Date: Feb 6, 2017