Double Cross-Linked Hydrogel Dressings Based on Triblock Copolymers Bearing Antifreezing, Antidrying, and Inherent Antibacterial Properties

Wang, Qian; Liang, Xi; Shen, Lingyi; Xu, Hong; Wang, Zhiyong; Redshaw, Carl; Zhang, Qilong

doi:10.1021/acs.biomac.3c01040

Double Cross-Linked Hydrogel Dressings Based on Triblock Copolymers Bearing Antifreezing, Antidrying, and Inherent Antibacterial Properties

Wang, Qian; Liang, Xi; Shen, Lingyi; Xu, Hong; Wang, Zhiyong; Redshaw, Carl; Zhang, Qilong

Authors

Qian Wang

Xi Liang

Lingyi Shen

Hong Xu

Zhiyong Wang

Carl Redshaw

Qilong Zhang

Abstract

Bacterial infections typically invade the living tissue of wounds, thereby aggravating the inflammatory response, delaying wound healing, or causing further complications. In this paper, the antibacterial hydrogel (PNVBA) with antifreezing and antidrying properties was prepared by a two-step method using N-isopropylacrylamide (NIPAM), 1-butyl-3-vinylimidazolium bromide (VBIMBr), and 3-acrylamidophenylboronic acid (AAPBA). PNVBA hydrogels exhibited a high adsorption capacity of 280 mg·g-1 for bovine serum albumin (BSA) and can adhere to the surface of different materials through ion-dipole or hydrogen-bonding interactions. Meanwhile, the PNVBA hydrogels exhibited high viscoelasticity and good adhesion after freezing at −20 °C or heating at 70 °C for 24 h with a sterilizing rate of up to 98% against multidrug-resistant (MDR) Escherichia coli and methicillin-resistant Staphylococcus aureus (MRSA). Moreover, a survival rate of up to 90% after incubation with L929 cells over 24 h was observed. Therefore, this inherent antibacterial hydrogel can be used as an excellent alternative material for wound dressings.

Citation

Wang, Q., Liang, X., Shen, L., Xu, H., Wang, Z., Redshaw, C., & Zhang, Q. (2024). Double Cross-Linked Hydrogel Dressings Based on Triblock Copolymers Bearing Antifreezing, Antidrying, and Inherent Antibacterial Properties. Biomacromolecules, 25(1), 388-399. https://doi.org/10.1021/acs.biomac.3c01040

Journal Article Type	Article
Acceptance Date	Dec 15, 2023
Online Publication Date	Dec 27, 2023
Publication Date	Jan 8, 2024
Deposit Date	Jan 20, 2024
Publicly Available Date	Dec 28, 2024
Journal	Biomacromolecules
Print ISSN	1525-7797
Publisher	American Chemical Society
Peer Reviewed	Peer Reviewed
Volume	25
Issue	1
Pages	388-399
DOI	https://doi.org/10.1021/acs.biomac.3c01040
Keywords	Absorption; Anatomy; Bacteria; Hydrogels; Surface interactions
Public URL	https://hull-repository.worktribe.com/output/4520252

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Copyright Statement
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Biomacromolecules, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.biomac.3c01040