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Detection of basic amino acids under highly alkaline conditions using a perylene amine-derived probe

Zhang, Ting ting; Lu, Yun; Lu, Ji Hong; Zhao, An Ting; Redshaw, Carl; Xiao, Xin


Ting ting Zhang

Yun Lu

Ji Hong Lu

An Ting Zhao

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Professor Carl Redshaw
Professor of Inorganic Materials Chemistry and REF Lead for Chemistry

Xin Xiao


pH plays a crucial part in numerous chemical and physiological processes. In this work, a new perylene diimide derivative that acts as a pH-sensitive dye with Bay Area Carboxylic Acid functionality. The derivative utilizes the outstanding thermal, chemical and photochemical stability found in PDI materials and has remarkable UV–visible absorption and fluorescence emission qualities. Based on these properties, a fluorescent probe (PCA) was synthesised using a perylene tetracarbodiimide (PDI) backbone for the recognition of alkaline pH. In alkaline environments where the pH values are between 10 and 14, the fluorescence intensity significantly decreases, and a blue shift occurs, which is a standard feature of alkaline pH probes. The probe demonstrates exceptional sensing ability within the pH range of 10.00–14.00, with notable stability and reversibility. Encapsulation of the probe in a thin polymer film material enhances the pH sensing capability of the system. New sensor has been developed to detect basic amino acids by utilizing the probes' pH response characteristics. this sensor has also been applied to detect the concentration of arginine.


Zhang, T. T., Lu, Y., Lu, J. H., Zhao, A. T., Redshaw, C., & Xiao, X. (2024). Detection of basic amino acids under highly alkaline conditions using a perylene amine-derived probe. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 309, Article 123835.

Journal Article Type Article
Acceptance Date Jan 1, 2024
Online Publication Date Jan 2, 2024
Publication Date Mar 15, 2024
Deposit Date Feb 3, 2024
Publicly Available Date Jan 3, 2025
Journal Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Print ISSN 1386-1425
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 309
Article Number 123835
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