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Fabrication of tailorable pH responsive cationic amphiphilic microgels on a microfluidic device for drug release

Lu, Bingyuan; Tarn, Mark D.; Pamme, Nicole; Georgiou, Theoni K.


Bingyuan Lu

Mark D. Tarn

Nicole Pamme

Theoni K. Georgiou


Cationic, amphiphilic microgels of differing compositions based on hydrophilic, pH, and thermoresponsive 2-(dimethylamino)ethyl methacrylate (DMAEMA) and hydrophobic, nonionic n-butyl acrylate (BuA) are synthesized using a lab-on-a-chip device. Hydrophobic oil-in-water (o/w) droplets are generated via a microfluidic platform, with the dispersed (droplet) phase containing the DMAEMA and BuA, alongside the hydrophobic cross-linker, ethylene glycol dimethacrylate, and a free radical initiator in an organic solvent. Finally, the hydrophobic droplets are photopolymerized via a UV light source as they traverse the microfluidic channel to produce the cationic amphiphilic microgels. This platform enables the rapid, automated, and in situ production of amphiphilic microgels, which do not match the core-shell structure of conventionally prepared microgels but are instead based on random amphiphilic copolymers of DMAEMA and BuA between the hydrophobic cross-links. The microgels are characterized in terms of their swelling and encapsulation abilities, which are found to be influenced by both the pH response and the hydrophobic content of the microgels. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018, 56, 59–66.


Lu, B., Tarn, M. D., Pamme, N., & Georgiou, T. K. (2018). Fabrication of tailorable pH responsive cationic amphiphilic microgels on a microfluidic device for drug release. Journal of Polymer Science Part A: Polymer Chemistry, 56(1), 59-66.

Journal Article Type Article
Acceptance Date Sep 9, 2017
Online Publication Date Oct 15, 2017
Publication Date Jan 1, 2018
Deposit Date Sep 11, 2017
Publicly Available Date Oct 27, 2022
Journal Journal of polymer science. Part A, Polymer chemistry
Print ISSN 0887-624X
Electronic ISSN 1099-0518
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 56
Issue 1
Pages 59-66
Keywords Microgel; Microfluidics; Photopolymerization; Amphiphilic gels
Public URL
Publisher URL
Additional Information This is the accepted manuscript of an article published in Journal of polymer science. Part A, Polymer chemistry, 2018. The version of record is available at the DOI link in this record.


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