Ming Zhang
Pickering emulsion droplets and solid microspheres acting synergistically for continuous-flow cascade reactions
Zhang, Ming; Ettelaie, Rammile; Li, Ting; Yang, Jianqin; Dong, Lianlian; Xue, Nan; Binks, Bernard P.; Cheng, Fangqin; Yang, Hengquan
Authors
Rammile Ettelaie
Ting Li
Jianqin Yang
Lianlian Dong
Nan Xue
Professor Bernie Binks B.P.Binks@hull.ac.uk
Emeritus Professor of Physical Chemistry
Fangqin Cheng
Hengquan Yang
Abstract
Integration of multiple incompatible catalysts in one continuous-flow reaction system is of paramount significance for green synthetic chemistry. Here we develop a continuous-flow cascade catalytic system by co-packing micrometre-sized Pickering emulsion droplets and solid microspheres in a column reactor. This co-packed system can not only provide the optimum microenvironments for each incompatible catalyst but also enables them to work synergistically through directional transfer of reaction intermediates. The success of the concept is based on a phenomenon found here, namely coexistence of Pickering emulsion droplets and solid microspheres without droplet disruption even under flow and high pressure due to specific interfacial effects. As proof of concept, two chemoenzymatic cascade reactions for synthesis of chiral cyanohydrins and chiral esters were examined; both these reactions exhibited 7-fold to 77-fold enhanced catalysis efficiency compared with their batch reactions, 99% enantioselectivity and long-term operational stability (240 h). (Figure presented.)
Citation
Zhang, M., Ettelaie, R., Li, T., Yang, J., Dong, L., Xue, N., …Yang, H. (2024). Pickering emulsion droplets and solid microspheres acting synergistically for continuous-flow cascade reactions. Nature Catalysis, https://doi.org/10.1038/s41929-024-01110-x
Journal Article Type | Article |
---|---|
Acceptance Date | Jan 12, 2024 |
Online Publication Date | Feb 13, 2024 |
Publication Date | Jan 1, 2024 |
Deposit Date | Feb 25, 2024 |
Publicly Available Date | Jul 2, 2024 |
Journal | Nature Catalysis |
Electronic ISSN | 2520-1158 |
Publisher | Nature Research |
Peer Reviewed | Peer Reviewed |
DOI | https://doi.org/10.1038/s41929-024-01110-x |
Keywords | Biocatalysis; Catalyst synthesis; Flow chemistry; Heterogeneous catalysis |
Public URL | https://hull-repository.worktribe.com/output/4558312 |
Files
Accepted manuscript
(2.1 Mb)
PDF
Copyright Statement
Copyright © 2024, The Author(s), under exclusive licence to Springer Nature Limited.
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s41929-024-01110-x
You might also like
Cholic Acid/Glutathione-Assembled Nanofibrils for Stabilizing Pickering Emulsion Biogels
(2024)
Journal Article
Competition between hydrogen bonding and electrostatic repulsion in pH-switchable emulsions
(2023)
Journal Article
Highly efficient and recyclable monolithic bioreactor for interfacial enzyme catalysis
(2023)
Journal Article
Downloadable Citations
About Repository@Hull
Administrator e-mail: repository@hull.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search