Skip to main content

Research Repository

Advanced Search

Pickering emulsion droplets and solid microspheres acting synergistically for continuous-flow cascade reactions

Zhang, Ming; Ettelaie, Rammile; Li, Ting; Yang, Jianqin; Dong, Lianlian; Xue, Nan; Binks, Bernard P.; Cheng, Fangqin; Yang, Hengquan

Authors

Ming Zhang

Rammile Ettelaie

Ting Li

Jianqin Yang

Lianlian Dong

Nan Xue

Fangqin Cheng

Hengquan Yang



Abstract

Integration of multiple incompatible catalysts in one continuous-flow reaction system is of paramount significance for green synthetic chemistry. Here we develop a continuous-flow cascade catalytic system by co-packing micrometre-sized Pickering emulsion droplets and solid microspheres in a column reactor. This co-packed system can not only provide the optimum microenvironments for each incompatible catalyst but also enables them to work synergistically through directional transfer of reaction intermediates. The success of the concept is based on a phenomenon found here, namely coexistence of Pickering emulsion droplets and solid microspheres without droplet disruption even under flow and high pressure due to specific interfacial effects. As proof of concept, two chemoenzymatic cascade reactions for synthesis of chiral cyanohydrins and chiral esters were examined; both these reactions exhibited 7-fold to 77-fold enhanced catalysis efficiency compared with their batch reactions, 99% enantioselectivity and long-term operational stability (240 h). (Figure presented.)

Citation

Zhang, M., Ettelaie, R., Li, T., Yang, J., Dong, L., Xue, N., …Yang, H. (2024). Pickering emulsion droplets and solid microspheres acting synergistically for continuous-flow cascade reactions. Nature Catalysis, https://doi.org/10.1038/s41929-024-01110-x

Journal Article Type Article
Acceptance Date Jan 12, 2024
Online Publication Date Feb 13, 2024
Publication Date Jan 1, 2024
Deposit Date Feb 25, 2024
Publicly Available Date Jul 2, 2024
Journal Nature Catalysis
Electronic ISSN 2520-1158
Publisher Nature Research
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1038/s41929-024-01110-x
Keywords Biocatalysis; Catalyst synthesis; Flow chemistry; Heterogeneous catalysis
Public URL https://hull-repository.worktribe.com/output/4558312

Files

Accepted manuscript (2.1 Mb)
PDF

Copyright Statement
Copyright © 2024, The Author(s), under exclusive licence to Springer Nature Limited.
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1038/s41929-024-01110-x




You might also like



Downloadable Citations