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Cholic Acid/Glutathione-Assembled Nanofibrils for Stabilizing Pickering Emulsion Biogels

Bi, Wenzhi; Le, Mengqi; Jia, Yong Guang; Bao, Zeyu; Sun, Shuo; Wang, Chaoyang; Binks, Bernard P.; Chen, Yunhua

Authors

Wenzhi Bi

Mengqi Le

Yong Guang Jia

Zeyu Bao

Shuo Sun

Chaoyang Wang

Yunhua Chen



Abstract

Achieving the delicate balance required for both emulsion and gel characteristics, while also imparting biological functionality in gelled emulsions, poses a significant challenge. Herein, Pickering emulsion biogels stabilized is reported by novel biological nanofibrils assembled from natural glutathione (GSH) and a tripod cholic acid derivative (TCA) via electrostatic interactions. GSH, composed of tripeptides with carboxyl groups, facilitates the protonation and dissolution of TCA compounds in water and the electrostatic interactions between GSH and TCA trigger nanofibrillar assembly. Fibrous nuclei initially emerge, and the formed mature nanofibrils can generate a stable hydrogel at a low solid concentration. These nanofibrils exhibit efficient emulsifying capability, enabling the preparation of stable Pickering oil-in-water (O/W) emulsion gels with adjustable phase volume ratios. The entangled nanofibrils adsorbed at the oil-water interface restrict droplet movement, imparting viscoelasticity and injectability to the emulsions. Remarkably, the biocompatible nanofibrils and stabilized emulsion gels demonstrate promising scavenging properties against reactive oxygen species (ROS). This strategy may open new scenarios for the design of advanced emulsion gel materials using natural precursors and affordable building blocks for biomedical applications.

Citation

Bi, W., Le, M., Jia, Y. G., Bao, Z., Sun, S., Wang, C., Binks, B. P., & Chen, Y. (online). Cholic Acid/Glutathione-Assembled Nanofibrils for Stabilizing Pickering Emulsion Biogels. Small, https://doi.org/10.1002/smll.202403667

Journal Article Type Article
Acceptance Date Aug 1, 2024
Online Publication Date Aug 15, 2024
Deposit Date Sep 11, 2024
Publicly Available Date Aug 16, 2025
Journal Small
Print ISSN 1613-6810
Publisher Wiley
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1002/smll.202403667
Public URL https://hull-repository.worktribe.com/output/4791022

Files

This file is under embargo until Aug 16, 2025 due to copyright reasons.

Contact B.P.Binks@hull.ac.uk to request a copy for personal use.



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