Effects of Exercise Training Response on Quality of Life and Cardiovascular Risk Factor Profiles in People With Coronary Artery Disease: Insights From the HIIT or MISS UK Trial

Ingle, Lee; Powell, Richard; Begg, Brian; Birkett, Stefan; Nichols, Simon; Ennis, Stuart; Banerjee, Pritwish; Shave, Rob; McGregor, Gordon

Abstract

Objective: To compare the characteristics of responders and nonresponders to 8 weeks of exercise training to determine differences in key cardiovascular disease outcomes in people with coronary artery disease (CAD). Design: Secondary analysis of data from the HIIT or MISS UK trial. Setting: Six outpatient National Health Service cardiac rehabilitation (CR) centers in the UK. In people with CAD attending CR, the HIIT or MISS UK trial reported that short-term, low-volume, high-intensity interval training (HIIT) was more effective than moderate-intensity steady state (MISS) exercise training for improving peak oxygen uptake (V̇O2peak). Participants: 382 participants with CAD (N=382) (mean age: 58.8±9.6y; mean body mass index: 29.0±4.3 kg/m2). Main Outcome Measures: We identified responders and nonresponders based on a meaningful change in V̇O2peak, using 2 established methods. Key clinical, quality of life (QoL), and cardiopulmonary exercise test (CPET)–derived outcomes were compared between groups. Results: Responders were more likely to be younger (P<.05), and demonstrate greater improvement in CPET-related outcomes, for example, oxygen uptake efficiency slope, ventilatory efficiency, and peak power output (all comparisons, P<.001). Responders were more likely to observe improvements in QoL (EQ-5D-5L; mean Δ 13.6 vs mean Δ 9.4; P=.045), and high-density lipoprotein cholesterol (HDL-c) (mean Δ 0.09 mmol/L vs mean Δ 0.04 mmol/L; P=.004), compared to nonresponders. Conclusions: In people with CAD attending CR, responders to exercise training were more likely to be younger and demonstrate greater improvements in health-related QoL and HDL-c.

Citation

Ingle, L., Powell, R., Begg, B., Birkett, S., Nichols, S., Ennis, S., Banerjee, P., Shave, R., & McGregor, G. (2024). Effects of Exercise Training Response on Quality of Life and Cardiovascular Risk Factor Profiles in People With Coronary Artery Disease: Insights From the HIIT or MISS UK Trial. Archives of physical medicine and rehabilitation, https://doi.org/10.1016/j.apmr.2024.03.002

• Journal Article Type: Article
• Acceptance Date: Mar 4, 2024
• Online Publication Date: Mar 16, 2024
• Publication Date: 2024
• Deposit Date: Mar 5, 2024
• Publicly Available Date: Mar 17, 2025
• Print ISSN: 0003-9993
• Publisher: Elsevier
• Peer Reviewed: Peer Reviewed
• DOI: https://doi.org/10.1016/j.apmr.2024.03.002
• Public URL: https://hull-repository.worktribe.com/output/4572145