Challenges in chelating positron emitting copper isotopes: tailored synthesis of unsymmetric chelators to form ultra stable complexes

Silversides, Jon D.; Smith, Rachel; Archibald, Stephen J.

Abstract

The synthesis of chelators that form high stability complexes with copper(II) isotopes and do not suffer from transchelation in vivo has been a goal for many chemists. Such chelators will facilitate the exploitation of the Cu-64 isotope (t(1/2) = 12.7 h, beta(+) (19%); beta(-) (39%); EC (41%)) for positron emission tomography imaging studies, which has a longer half life relative to the more commonly used F-18 (t(1/2) = 109.8 min) and C-11 (t(1/2) = 20.4 min) isotopes. One option is the CBTE2A chelator, which has been championed by Weisman, Wong and Anderson, and, more recently, alternate bifunctional chelator (BFC) versions have been synthesised. Improved synthetic methods are required for unsymmetric derivatisation of these chelators to allow more selective biomolecule attachment. This work investigates synthetic routes to form new unsymmetric chelating ligands via stepwise reaction of the bisaminal precursor, determines their X-ray structures and demonstrates cold copper(II) isotope complex formation.

Citation

Silversides, J. D., Smith, R., & Archibald, S. J. (2011). Challenges in chelating positron emitting copper isotopes: tailored synthesis of unsymmetric chelators to form ultra stable complexes. Dalton Transactions : an international journal of inorganic chemistry, 40(23), 6289-6297. https://doi.org/10.1039/c0dt01395a

• Journal Article Type: Article
• Acceptance Date: Mar 9, 2011
• Online Publication Date: Apr 1, 2011
• Publication Date: Jun 21, 2011
• Deposit Date: Nov 13, 2014
• Journal: Dalton Transactions
• Print ISSN: 1477-9226
• Electronic ISSN: 1477-9234
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 40
• Issue: 23
• Pages: 6289-6297
• DOI: https://doi.org/10.1039/c0dt01395a
• Keywords: Inorganic Chemistry
• Public URL: https://hull-repository.worktribe.com/output/462804
• Contract Date: Nov 13, 2014