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Functional and metabolic adaptation in uraemic cardiomyopathy

Smith, Katie; Semple, David; Aksentijević, Dunja; Bhandari, Sunil; Seymour, Anne-Marie L.

Authors

Katie Smith

David Semple

Dunja Aksentijević

Sunil Bhandari

Anne-Marie L. Seymour



Abstract

Cardiovascular complications are the leading cause of death in patients with chronic kidney disease (CKD). The uraemic heart undergoes substantial remodelling, including left ventricular hypertrophy (LVH), an important determinant of heart failure. LVH results in a shift in myocardial substrate oxidation from fatty acids towards carbohydrates however, whether this metabolic adaptation occurs in the uraemic heart is unknown. The aim of this study was to investigate the progression of kidney dysfunction in parallel with cardiac remodelling in experimental uraemia. Experimental uraemia was induced surgically via a subtotal nephrectomy. At 3, 6 and 12 weeks post-surgery, renal function, LVH, in vitro cardiac function and metabolic remodelling using 13C-NMR were assessed. Uraemic animals exhibited anaemia and kidney dysfunction at 3 weeks, with further deterioration as uraemia progressed. By 12 weeks, uraemic hearts showed marked LVH, preserved cardiac function and markedly reduced fatty acid oxidation. This change in substrate preference may contribute to the deterioration of cardiac function in the uraemic heart and ultimately failure.

Citation

Smith, K., Semple, D., Aksentijević, D., Bhandari, S., & Seymour, A. L. (2010). Functional and metabolic adaptation in uraemic cardiomyopathy. Frontiers in bioscience (Elite edition), E2(4), 1492-1501. doi:10.2741/e208

Journal Article Type Article
Acceptance Date Jan 1, 2010
Publication Date 2010-06
Deposit Date Nov 13, 2014
Journal Frontiers In Bioscience (Elite Edition)
Print ISSN 1945-0494
Electronic ISSN 1945-0508
Peer Reviewed Peer Reviewed
Volume E2
Issue 4
Pages 1492-1501
DOI https://doi.org/10.2741/e208
Keywords Chronic kidney disease, uraemic cardiomyopathy, left ventricular hypertrophy, metabolic remodelling, 13C NMR,
Public URL https://hull-repository.worktribe.com/output/467505
Additional Information https://www.bioscience.org/rights-and-permissions states: Frontiers in Bioscience grants permission to all authors, readers and third parties of educational nature to reproduce and use published material and online resources as part of another publication or entity. This permission is granted free of charge provided that: If used online, the use should be for a timeline not longer than 1 month.