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Event-related brain potentials in the study of inhibition: cognitive control, source localization and age-related modulations

Pires, Luis; Leitao, Jose; Simoes, Mario R.; Pires, Luís; Leitão, José; Guerrini, Chiara; Simões, Mário R.

Authors

Luis Pires

Jose Leitao

Mario R. Simoes

Luís Pires

José Leitão

Mário R. Simões



Abstract

In the previous 15 years, a variety of experimental paradigms and methods have been employed to study inhibition. In the current review, we analyze studies that have used the high temporal resolution of the event-related potential (ERP) technique to identify the temporal course of inhibition to understand the various processes that contribute to inhibition. ERP studies with a focus on normal aging are specifically analyzed because they contribute to a deeper understanding of inhibition. Three time windows are proposed to organize the ERP data collected using inhibition paradigms: the 200 ms period following stimulus onset; the period between 200 and 400 ms after stimulus onset; and the period between 400 and 800 ms after stimulus onset. In the first 200 ms, ERP inhibition research has primarily focused on N1 and P1 as the ERP components associated with inhibition. The inhibitory processing in the second time window has been associated with the N2 and P3 ERP components. Finally, in the third time window, inhibition has primarily been associated with the N400 and N450 ERP components. Source localization studies are analyzed to examine the association between the inhibition processes that are indexed by the ERP components and their functional brain areas. Inhibition can be organized in a complex functional structure that is not constrained to a specific time point but, rather, extends its activity through different time windows. This review characterizes inhibition as a set of processes rather than a unitary process.

Citation

Pires, L., Leitão, J., Guerrini, C., & Simões, M. R. (2014). Event-related brain potentials in the study of inhibition: cognitive control, source localization and age-related modulations. Neuropsychology Review, 24(4), 461-490. doi:10.1007/s11065-014-9275-4

Journal Article Type Article
Acceptance Date Nov 4, 2014
Online Publication Date Nov 19, 2014
Publication Date 2014-12
Deposit Date Feb 26, 2016
Publicly Available Date Nov 23, 2017
Journal Neuropsychology review
Print ISSN 1040-7308
Electronic ISSN 1573-6660
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 24
Issue 4
Pages 461-490
DOI https://doi.org/10.1007/s11065-014-9275-4
Keywords Inhibition, Cognitive control, Event-related potentials, Source localization, Aging
Public URL https://hull-repository.worktribe.com/output/471824
Publisher URL http://link.springer.com/article/10.1007%2Fs11065-014-9275-4
Copyright Statement ©2016 University of Hull
Additional Information Neuropsychology review The final publication is available at Springer via http://dx.doi.org/[insert DOI]

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