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On-chip processing of particles and cells via multilaminar flow streams

Tarn, Mark D.; Lopez-Martinez, Maria J.; Pamme, Nicole


Mark D. Tarn

Maria J. Lopez-Martinez

Nicole Pamme


The processing of particles, cells, and droplets for reactions, analyses, labeling, and coating is an important aspect of many microfluidic workflows. However, performing multi-step processes is typically a laborious and timeconsuming endeavor. By exploiting the laminar nature of flow within microchannels, such procedures can benefit in terms of both speed and simplicity. This can be achieved either by manipulating the flow streams around the objects of interest, particularly for the localized perfusion of cells, or by manipulating the objects themselves within the streams via a range of forces. Here, we review the variety of methods that have been employed for performing such "multilaminar flow" procedures on particles, cells, and droplets. © Springer-Verlag Berlin Heidelberg 2013.


Tarn, M. D., Lopez-Martinez, M. J., & Pamme, N. (2014). On-chip processing of particles and cells via multilaminar flow streams. Analytical and Bioanalytical Chemistry, 406(1), 139-161.

Journal Article Type Review
Acceptance Date Sep 10, 2013
Online Publication Date Oct 23, 2013
Publication Date 2014-01
Deposit Date Dec 8, 2020
Journal Analytical and Bioanalytical Chemistry
Print ISSN 1618-2642
Electronic ISSN 1618-2650
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 406
Issue 1
Pages 139-161
Keywords Continuous flow; Microfluidics; Microparticles; Cells; Droplets; Trapping; Deflection; Multilaminar flow
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