On-chip processing of particles and cells via multilaminar flow streams

Tarn, Mark D.; Lopez-Martinez, Maria J.; Pamme, Nicole

Abstract

The processing of particles, cells, and droplets for reactions, analyses, labeling, and coating is an important aspect of many microfluidic workflows. However, performing multi-step processes is typically a laborious and timeconsuming endeavor. By exploiting the laminar nature of flow within microchannels, such procedures can benefit in terms of both speed and simplicity. This can be achieved either by manipulating the flow streams around the objects of interest, particularly for the localized perfusion of cells, or by manipulating the objects themselves within the streams via a range of forces. Here, we review the variety of methods that have been employed for performing such "multilaminar flow" procedures on particles, cells, and droplets. © Springer-Verlag Berlin Heidelberg 2013.

Citation

Tarn, M. D., Lopez-Martinez, M. J., & Pamme, N. (2014). On-chip processing of particles and cells via multilaminar flow streams. Analytical and Bioanalytical Chemistry, 406(1), 139-161. https://doi.org/10.1007/s00216-013-7363-6

• Journal Article Type: Review
• Acceptance Date: Sep 10, 2013
• Online Publication Date: Oct 23, 2013
• Publication Date: 2014-01
• Deposit Date: Dec 8, 2020
• Journal: Analytical and Bioanalytical Chemistry
• Print ISSN: 1618-2642
• Electronic ISSN: 1618-2650
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 406
• Issue: 1
• Pages: 139-161
• DOI: https://doi.org/10.1007/s00216-013-7363-6
• Keywords: Continuous flow; Microfluidics; Microparticles; Cells; Droplets; Trapping; Deflection; Multilaminar flow
• Public URL: https://hull-repository.worktribe.com/output/519953
• Publisher URL: https://link.springer.com/article/10.1007/s00216-013-7363-6