Skip to main content

Research Repository

Advanced Search

Rho Signaling in Dictyostelium discoideum

Rivero Crespo, Francisco; Xiong, Huajiang


Huajiang Xiong


© 2016 Elsevier Inc. Small GTPases of the Rho family are ubiquitous molecular switches involved in the regulation of most actin cytoskeleton dependent processes and many other processes not directly linked to actin. D. discoideum is a well-established model organism for studies of the actin cytoskeleton and its regulation by signal transduction pathways. D. discoideum is equipped with a complex repertoire of Rho signaling components, with 20 Rho GTPases, more than 100 regulators (including exchange factors, GTPase activating proteins and guanine nucleotide dissociation inhibitors), and nearly 80 effectors or components of effector complexes. In this review we examine the knowledge accumulated to date about proteins involved in Rho-regulated signaling pathways in D. discoideum, with an emphasis on functional studies. We integrate the information about individual components into defined signaling pathways, with a focus on three extensively investigated processes: chemotaxis, vesicle trafficking, and cytokinesis.


Rivero Crespo, F., & Xiong, H. (2016). Rho Signaling in Dictyostelium discoideum. International review of cell and molecular biology, 322, 61-181.

Journal Article Type Article
Online Publication Date Dec 23, 2015
Publication Date 2016
Deposit Date Apr 1, 2022
Journal International Review of Cell and Molecular Biology
Print ISSN 1937-6448
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 322
Pages 61-181
Keywords Chemotaxis; Cytokinesis; Cytoskeleton; Dictyostelium; Endocytosis; Rho GTPase; Vesicle trafficking
Public URL