Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens

Caserta, Stefano; Borger, Jessica Geraldine; Zamoyska, Rose

Abstract

Harnessing T-cell responses to constrain tumor growth is a realistic treatment aspiration in tumor medicine, as many tumors express specific tumor associated antigens that are recognized by the adaptive immune system. CD8 T cells have direct cytolytic activity against tumor cells, and CD4 T cells mount a variety of responses that have important influences on tumor growth. We discuss how individual T-cell subsets contribute to antitumor responses and the goals and problems associated with generating and/or maintaining effective multifunctional T-cell responses to provide long-term protection against tumors. © 2012 by Begell House, Inc.

Citation

Caserta, S., Borger, J. G., & Zamoyska, R. (2012). Central and effector memory CD4 and CD8 T-cell responses to tumor-associated antigens. Critical reviews in immunology, 32(2), 97-126. https://doi.org/10.1615/critrevimmunol.v32.i2.10

• Journal Article Type: Article
• Acceptance Date: Feb 11, 2012
• Publication Date: May 11, 2012
• Deposit Date: Jun 28, 2018
• Journal: Critical Reviews in Immunology
• Print ISSN: 1040-8401
• Publisher: Begell House
• Peer Reviewed: Peer Reviewed
• Volume: 32
• Issue: 2
• Pages: 97-126
• DOI: https://doi.org/10.1615/critrevimmunol.v32.i2.10
• Keywords: Memory T cells; Cancer; Self-renewal; T-cell differentiation; Immunotherapy; Adoptive cell therapy
• Public URL: https://hull-repository.worktribe.com/output/620540
• Publisher URL: http://www.dl.begellhouse.com/journals/2ff21abf44b19838,3bfedc2e7294b37d,09e11aee5a609357.html