Skip to main content

Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells

Caserta, Stefano; Nausch, Norman; Sawtell, Amy; Drummond, Rebecca; Barr, Tom; MacDonald, Andrew S.; Mutapi, Francisca; Zamoyska, Rose

Authors

Norman Nausch

Amy Sawtell

Rebecca Drummond

Tom Barr

Andrew S. MacDonald

Francisca Mutapi

Rose Zamoyska



Contributors

Mauricio Martins Rodrigues
Editor

Abstract

Certain parasites have evolved to evade the immune response and establish chronic infections that may persist for many years. T cell responses in these conditions become muted despite ongoing infection. Upregulation of surface receptors with inhibitory properties provides an immune cell-intrinsic mechanism that, under conditions of chronic infection, regulates immune responses and limits cellular activation and associated pathology. The negative regulator, CD200 receptor, and its ligand, CD200, have been shown to regulate macrophage activation and reduce pathology following infection. We show that CD4 T cells also increase expression of inhibitory CD200 receptors (CD200R) in response to chronic infection. CD200R was upregulated on murine effector T cells in response to infection with bacterial, Salmonella enterica, or helminth, Schistosoma mansoni, pathogens that respectively drive predominant Th1- or Th2-responses. In vitro chronic and prolonged stimuli were required for the sustained upregulation of CD200R, and its expression coincided with loss of multifunctional potential in T effector cells during infection. Importantly, we show an association between IL-4 production and CD200R expression on T effector cells from humans infected with Schistosoma haematobium that correlated effectively with egg burden and, thus infection intensity. Our results indicate a role of CD200R:CD200 in T ce ll responses to helminths which has diagnostic and prognostic relevance as a marker of infection for chronic schistosomiasis in mouse and man. © 2012 Caserta et al.

Journal Article Type Article
Publication Date Apr 9, 2012
Journal PLoS ONE
Print ISSN 1932-6203
Electronic ISSN 1932-6203
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 7
Issue 4
Article Number e35466
Pages e35466
APA6 Citation Caserta, S., Nausch, N., Sawtell, A., Drummond, R., Barr, T., MacDonald, A. S., …Zamoyska, R. (2012). Chronic infection drives expression of the inhibitory receptor CD200R, and its ligand CD200, by mouse and human CD4 T cells. PloS one, 7(4), e35466. https://doi.org/10.1371/journal.pone.0035466
DOI https://doi.org/10.1371/journal.pone.0035466
Keywords T cells; T helper cells; Cytokines; Helminth infections; Cell staining; Schistosoma mansoni; Schistosomiasis; Spleen
Publisher URL http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0035466
Copyright Statement © 2012 Caserta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Files

Article (1.5 Mb)
PDF

Copyright Statement
© 2012 Caserta et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



You might also like



Downloadable Citations

;