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T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance

Salmond, Robert J.; Filby, Andrew; Qureshi, Ihjaaz; Caserta, Stefano; Zamoyska, Rose

Authors

Robert J. Salmond

Andrew Filby

Ihjaaz Qureshi

Rose Zamoyska



Abstract

T-cell development in the thymus and activation of mature T cells in secondary lymphoid organs requires the ability of cells to respond appropriately to environmental signals at multiple stages of their development. The process of thymocyte selection insures a functional T-cell repertoire, while activation of naive peripheral T cells induces proliferation, gain of effector function, and, ultimately, long-lived T-cell memory. The T-cell immune response is initiated upon engagement of the T-cell receptor (TCR) and coreceptor, CD4 or CD8, by cognate antigen/major histocompatibility complexes presented by antigen-presenting cells. TCR/coreceptor engagement induces the activation of biochemical signaling pathways that, in combination with signals from costimulator molecules and cytokine receptors, direct the outcome of the response. Activation of the src-family kinases p56 lck (Lck) and p59 fyn (Fyn) is central to the initiation of TCR signaling pathways. This review focuses on our current understanding of the mechanisms by which these two proteins orchestrate T-cell function. © 2009 Blackwell Munksgaard.

Journal Article Type Article
Publication Date Mar 1, 2009
Journal Immunological Reviews
Print ISSN 0105-2896
Electronic ISSN 1600-065X
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 228
Issue 1
Pages 9-22
APA6 Citation Salmond, R. J., Filby, A., Qureshi, I., Caserta, S., & Zamoyska, R. (2009). T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance. Immunological reviews, 228(1), 9-22. https://doi.org/10.1111/j.1600-065x.2008.00745.x
DOI https://doi.org/10.1111/j.1600-065x.2008.00745.x
Keywords T cells; Autoimmunity; Signaling proteins; Cell differentiation; Transgenic/knockout mice
Publisher URL https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-065X.2008.00745.x
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