Clinical trials update from the Heart Failure Society of America: EMOTE, HERB-CHF, BEST genetic sub-study and RHYTHM-ICD

Lalukota, Krishna; Cleland, John G.F.; Ingle, Lee; Clark, Andrew L.; Coletta, Alison P.

Abstract

This article summarises key presentations relevant to the pathophysiology, prevention or treatment of heart failure, from the Heart Failure Society of America annual meeting held in Toronto, Canada. Data from the EnoxiMone in intravenous inOTropE-dependent subjects (EMOTE) study suggest that the oral PDE-3 inhibitor enoximone may be effective for weaning severe heart failure patients from intravenous inotropic therapy. Hawthorn Extract Randomised Blinded Trial in CHF (HERB-CHF) failed to show a benefit of hawthorn extract added to conventional heart failure therapy. A genetic sub-group analysis of the Blocker Evaluation of Survival Trial (BEST) study showed that bucindolol reduced mortality and hospitalisations in patients who were homozygous for the Arg389 variant of the β 1 adrenoceptor. In the Resynchronisation Hemodynamic Treatment for Heart Failure Management (RHYTHM-ICD) study, patients randomised to cardiac resynchronisation therapy (CRT) showed an improvement in symptoms and functional capacity compared to the control group. © 2004 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

Citation

Lalukota, K., Cleland, J. G., Ingle, L., Clark, A. L., & Coletta, A. P. (2004). Clinical trials update from the Heart Failure Society of America: EMOTE, HERB-CHF, BEST genetic sub-study and RHYTHM-ICD. European journal of heart failure, 6(7), 953-955. https://doi.org/10.1016/j.ejheart.2004.10.003

• Journal Article Type: Article
• Acceptance Date: Oct 3, 2004
• Online Publication Date: Dec 14, 2004
• Publication Date: 2004-12
• Deposit Date: May 7, 2019
• Journal: European Journal of Heart Failure
• Print ISSN: 1388-9842
• Publisher: Wiley
• Peer Reviewed: Peer Reviewed
• Volume: 6
• Issue: 7
• Pages: 953-955
• DOI: https://doi.org/10.1016/j.ejheart.2004.10.003
• Keywords: EMOTE; HERB‐CHF; BEST genetic sub‐study; RHYTHM‐ICD
• Public URL: https://hull-repository.worktribe.com/output/738427
• Publisher URL: https://onlinelibrary.wiley.com/doi/full/10.1016/j.ejheart.2004.10.003