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Clinical trials update from the European Society of Cardiology Heart Failure meeting and the American College of Cardiology: Darbepoetin alfa study, ECHOS, and ASCOT-BPLA

Cleland, John G.F.; Coletta, Alison P.; Clark, Andrew L.; Velavan, Periaswamy; Ingle, Lee

Authors

John G.F. Cleland

Alison P. Coletta

Andrew L. Clark

Periaswamy Velavan

Abstract

This article provides information and a commentary on landmark trials presented at the European Society of Cardiology Heart Failure meeting held in June 2005, relevant to the pathophysiology, prevention and treatment of heart failure. All reports should be considered as preliminary data, as analyses may change in the final publication. The erythropoiesis stimulating protein, darbepoetin alfa, increased haemoglobin levels, improved quality of life and showed a trend for improved exercise duration in anaemic patients with symptomatic chronic heart failure. In the ECHOS study, the selective dopamine agonist nolomirole (CHF1035) showed no benefit in heart failure patients. Preliminary results of the ASCOT-BPLA study, which were reported at the American College of Cardiology meeting in March 2005, showed that in hypertensive patients, treatment with a calcium antagonist plus an ACE inhibitor was more effective at reducing cardiovascular outcomes than atenolol plus a diuretic. © 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

Journal Article Type Conference Paper
Publication Date 2005-08
Journal European Journal of Heart Failure
Print ISSN 1388-9842
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 7
Issue 5
Pages 937-939
Institution Citation Cleland, J. G., Coletta, A. P., Clark, A. L., Velavan, P., & Ingle, L. (2005). Clinical trials update from the European Society of Cardiology Heart Failure meeting and the American College of Cardiology: Darbepoetin alfa study, ECHOS, and ASCOT-BPLA. European journal of heart failure, 7(5), 937-939. https://doi.org/10.1016/j.ejheart.2005.07.001
DOI https://doi.org/10.1016/j.ejheart.2005.07.001
Keywords Darbepoetin alfa; ECHOS; ASCOT‐BPLA
Publisher URL https://onlinelibrary.wiley.com/doi/full/10.1016/j.ejheart.2005.07.001