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Interleukin-7 unveils Pathogen-Specific T Cells by enhancing Antigen-Recall responses

Terrazzini, Nadia; Mantegani, Paola; Kern, Florian; Fortis, Claudio; Mondino, Anna; Caserta, Stefano

Authors

Nadia Terrazzini

Paola Mantegani

Florian Kern

Claudio Fortis

Anna Mondino



Abstract

© 2018 The Author(s). Background Interleukin (IL)-7 promotes the generation, expansion, and survival of memory T cells. Previous mouse and human studies showed that IL-7 can support immune cell reconstitution in lymphopenic conditions, expand tumor-reactive T cells for adoptive immunotherapy, and enhance effector cytokine expression by autoreactive T cells. Whether pathogen-reactive T cells also benefit from IL-7 exposure remains unknown. Methods In this study, we investigated this issue in cultures of peripheral blood mononuclear cells (PBMCs) derived from patients infected with various endemic pathogens. After short-term exposure to IL-7, we measured PBMC responses to antigens derived from pathogens, such as Mycobacterium tuberculosis, Candida albicans, and cytomegalovirus, and to the superantigen Staphylococcus aureus enterotoxin B. Results We found that IL-7 favored the expansion and, i n some instances, the uncovering of pathogen-reactive CD4 T cells, by promoting pathogen-specific interferon-Î 3, IL-2, and tumor necrosis factor recall responses. Conclusions Our findings indicate that IL-7 unveils and supports reactivation of pathogen-specific T cells with possible diagnostic, prognostic, and therapeutic significance of clinical value, especially in conditions of pathogen persistence and chronic infection.

Citation

Terrazzini, N., Mantegani, P., Kern, F., Fortis, C., Mondino, A., & Caserta, S. (2018). Interleukin-7 unveils Pathogen-Specific T Cells by enhancing Antigen-Recall responses. The journal of infectious diseases : official publication of the Infectious Diseases Society of America, 217(12), 1997-2007. https://doi.org/10.1093/infdis/jiy096

Journal Article Type Article
Acceptance Date Feb 19, 2018
Online Publication Date Feb 28, 2018
Publication Date May 25, 2018
Deposit Date Jun 28, 2018
Publicly Available Date Mar 28, 2024
Journal Journal of Infectious Diseases
Print ISSN 0022-1899
Electronic ISSN 1537-6613
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 217
Issue 12
Pages 1997-2007
DOI https://doi.org/10.1093/infdis/jiy096
Keywords Candida infection; Pathogen-specific responses; SEB responses; TB infection
Public URL https://hull-repository.worktribe.com/output/876313
Publisher URL https://academic.oup.com/jid/article/217/12/1997/4913790

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Copyright Statement
© The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.





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