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Cough hypersensitivity syndrome: A few more steps forward (2017)
Journal Article
Song, W. J., & Morice, A. H. (2017). Cough hypersensitivity syndrome: A few more steps forward. Allergy Asthma and Immunology Research, 9(5), 394-402. https://doi.org/10.4168/aair.2017.9.5.394

© The Korean Academy of Asthma, Allergy and Clinical Immunology. Cough reflex is a vital protective mechanism against aspiration, but when dysregulated, it can become hypersensitive. In fact, chronic cough is a significant medical problem with a high... Read More about Cough hypersensitivity syndrome: A few more steps forward.

A new way to look at acute cough in the pharmacy (2017)
Journal Article
Morice, A. H. (2017). A new way to look at acute cough in the pharmacy. Pharmaceutical Journal, 9(4), https://doi.org/10.1211/CP.2017.20202484

© 2017 Royal Pharmaceutical Society. All rights reserved. Cough is the most common symptom for which people seek medical advice, and patients with cough frequently present to community pharmacy. Cough can be either acute or chronic. Acute cough, defi... Read More about A new way to look at acute cough in the pharmacy.

Point prevalence and epidemiological characteristics of chronic cough in the general adult population: The Korean National Health and Nutrition Examination Survey 2010-2012 (2017)
Journal Article
Kang, M. G., Song, W. J., Kim, H. J., Won, H. K., Sohn, K. H., Kang, S. Y., Jo, E. J., Kim, M. H., Kim, S. H., Kim, S. H., Park, H. W., Chang, Y. S., Lee, B. J., Morice, A. H., & Cho, S. H. (2017). Point prevalence and epidemiological characteristics of chronic cough in the general adult population: The Korean National Health and Nutrition Examination Survey 2010-2012. Medicine, 96(13), Article e6486. https://doi.org/10.1097/MD.0000000000006486

© 2017 the Author(s). Cough is frequently self-limiting, but may persist longer in certain individuals. Most of previous studies on the epidemiology of chronic cough have only measured period prevalence, and thus have afforded limited information on... Read More about Point prevalence and epidemiological characteristics of chronic cough in the general adult population: The Korean National Health and Nutrition Examination Survey 2010-2012.

Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation (2017)
Journal Article
Crooks, M. G., den Brinker, A., Hayman, Y., Williamson, J. D., Innes, A., Wright, C. E., Hill, P., & Morice, A. H. (2017). Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation. Lung, 195(3), 289-294. https://doi.org/10.1007/s00408-017-9996-2

Purpose Cough is common in chronic obstructive pulmonary disease (COPD) and is associated with frequent exacerbations and increased mortality. Cough increases during acute exacerbations (AE-COPD), representing a possible metric of clinical deteriorat... Read More about Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation.

The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration? (2017)
Journal Article
Hayman, Y. A., Sadofsky, L. R., Williamson, J. D., Hart, S. P., & Morice, A. H. (2017). The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration?. Ers Monograph, 3(1), 00026-2016. https://doi.org/10.1183/23120541.00026-2016

Chronic inflammatory diseases of the airways are associated with gastro-oesophageal reflux (GOR) and aspiration events. The observation of lipid laden macrophages (LLM) within the airway may indicate aspiration secondary to GOR. The proposed mechanis... Read More about The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration?.

Inhaled corticosteriod use and the risk of pneumonia and COPD exacerbations in the UPLIFT study (2017)
Journal Article
Morjaria, J. B., Morice, A. H., Morice, A., Rigby, A., & Morjaria, J. (2017). Inhaled corticosteriod use and the risk of pneumonia and COPD exacerbations in the UPLIFT study. Lung, 195(3), 281-288. https://doi.org/10.1007/s00408-017-9990-8

Rationale Unlike many other COPD studies, the 4-year UPLIFT trial permitted inhaled corticosteroid (ICS) use during run-in and treatment phases. This provided the opportunity to prospectively observe the continuing effects of ICS on respiratory event... Read More about Inhaled corticosteriod use and the risk of pneumonia and COPD exacerbations in the UPLIFT study.

TRPV1 polymorphisms influence capsaicin cough sensitivity in men (2017)
Journal Article
Sadofsky, L. R., Cantero-Recasens, G., Wright, C., Valverde, M. A., & Morice, A. H. (2017). TRPV1 polymorphisms influence capsaicin cough sensitivity in men. Journal of thoracic disease, 9(3), 839-840. https://doi.org/10.21037/jtd.2017.03.50

Capsaicin, the hot component of chilli peppers, is a well-known tussive agent, which is regularly used as a tool to study cough and antitussives (1). Capsaicin is known to activate the transient receptor potential vanilloid 1 (TRPV1) cation channel w... Read More about TRPV1 polymorphisms influence capsaicin cough sensitivity in men.

Tussive challenge with ATP and AMP: does it reveal cough hypersensitivity? (2017)
Journal Article
Fowles, H. E., Rowland, T., Wright, C., & Morice, A. (2017). Tussive challenge with ATP and AMP: does it reveal cough hypersensitivity?. European respiratory journal, 49(2), Article ARTN 1601452. https://doi.org/10.1183/13993003.01452-2016

Recent studies have demonstrated that blockade of P2X3 adenosine triphosphate (ATP) receptors may profoundly inhibit chronic cough. We have considered whether inhaled ATP produces a tussive response and whether chronic cough patients are hypersensiti... Read More about Tussive challenge with ATP and AMP: does it reveal cough hypersensitivity?.

The differential effects of systemic vasoconstrictors on human pulmonary artery tension (2017)
Journal Article
Hussain, A., Bennett, R., Haqzad, Y., Qadri, S., Chaudhry, M., Cowen, M., Loubani, M., & Morice, A. (2017). The differential effects of systemic vasoconstrictors on human pulmonary artery tension. European Journal of Cardio-Thoracic Surgery, 51(5), 880-886. https://doi.org/10.1093/ejcts/ezw410

© The Author 2017. Published by Oxford University Press. All rights reserved. Objectives: Acute pulmonary hypertension following cardiac surgery can have a significant effect on postoperative morbidity and mortality. However, limited data are availab... Read More about The differential effects of systemic vasoconstrictors on human pulmonary artery tension.

Hypoxic pulmonary vasoconstriction in humans: Tale or myth (2017)
Journal Article
Hussain, A., Suleiman, M. S., George, S. J., Loubani, M., & Morice, A. (2017). Hypoxic pulmonary vasoconstriction in humans: Tale or myth. Open Cardiovascular Medicine Journal, 11, 1-13. https://doi.org/10.2174/1874192401711010001

© Hussain et al. Hypoxic Pulmonary vasoconstriction (HPV) describes the physiological adaptive process of lungs to preserves systemic oxygenation. It has clinical implications in the development of pulmonary hypertension which impacts on outcomes of... Read More about Hypoxic pulmonary vasoconstriction in humans: Tale or myth.

Diagnostic accuracy of fractional exhaled nitric oxide measurement in predicting cough-variant asthma and eosinophilic bronchitis in adults with chronic cough: A systematic review and meta-analysis (2017)
Journal Article
Song, W. J., Kim, H. J., Shim, J. S., Won, H. K., Kang, S. Y., Sohn, K. H., Kim, B. K., Jo, E. J., Kim, M. H., Kim, S. H., Park, H. W., Kim, S. S., Chang, Y. S., Morice, A. H., Lee, B. J., & Cho, S. H. (2017). Diagnostic accuracy of fractional exhaled nitric oxide measurement in predicting cough-variant asthma and eosinophilic bronchitis in adults with chronic cough: A systematic review and meta-analysis. Journal of Allergy and Clinical Immunology, 140(3), 701-709. https://doi.org/10.1016/j.jaci.2016.11.037

© 2017 American Academy of Allergy, Asthma & Immunology Background Individual studies have suggested the utility of fractional exhaled nitric oxide (FENO) measurement in detecting cough-variant asthma (CVA) and eosinophilic bronchitis (EB) in patie... Read More about Diagnostic accuracy of fractional exhaled nitric oxide measurement in predicting cough-variant asthma and eosinophilic bronchitis in adults with chronic cough: A systematic review and meta-analysis.

Rococo study: a real-world evaluation of an over-the-counter medicine in acute cough (a multicentre, randomised, controlled study) (2017)
Journal Article
Birring, S. S., Brew, J., Kilbourn, A., Edwards, V., Wilson, R., & Morice, A. H. (2017). Rococo study: a real-world evaluation of an over-the-counter medicine in acute cough (a multicentre, randomised, controlled study). BMJ open, 7(1), e014112. https://doi.org/10.1136/bmjopen-2016-014112

Objectives To investigate the efficacy and safety of CS1002, an over-the-counter cough treatment containing diphenhydramine, ammonium chloride and levomenthol in a cocoa-based demulcent. Design A multicentre, randomised, parallel group, controlled... Read More about Rococo study: a real-world evaluation of an over-the-counter medicine in acute cough (a multicentre, randomised, controlled study).

Effect of ivacaftor on objective and subjective measures of cough in patients with cystic fibrosis (2016)
Journal Article
Faruqi, S., Shiferaw, D., & Morice, A. H. (2016). Effect of ivacaftor on objective and subjective measures of cough in patients with cystic fibrosis. Open Respiratory Medicine Journal, 10, 105-108. https://doi.org/10.2174/1874306401610010105

© Faruqi et al. Background and Objectives: Cough is a major symptom in cystic fibrosis. Ivacaftor is a novel drug which targets the G551D mutation and has been demonstrated to improve lung function and weight in the long term. It also improves sympto... Read More about Effect of ivacaftor on objective and subjective measures of cough in patients with cystic fibrosis.

Effect of aclidinium bromide on cough and sputum symptoms in moderate-to-severe COPD in three phase III trials (2016)
Journal Article
McGarvey, L., Morice, A. H., Smith, J. A., Birring, S. S., Chuecos, F., Seoane, B., & Jarreta, D. (2016). Effect of aclidinium bromide on cough and sputum symptoms in moderate-to-severe COPD in three phase III trials. BMJ Open Respiratory Research, 3(1), Article e000148. https://doi.org/10.1136/bmjresp-2016-000148

© 2016, BMJ Publishing Group. All rights reserved. Background: Cough and sputum are troublesome symptoms in chronic obstructive pulmonary disease (COPD) and are associated with adverse outcomes. The efficacy of aclidinium bromide 400 μg twice daily i... Read More about Effect of aclidinium bromide on cough and sputum symptoms in moderate-to-severe COPD in three phase III trials.

TRPA1 mediates aromatase inhibitor-evoked pain by the aromatase substrate androstenedione (2016)
Journal Article
Morice, A. H., Sadofsky, L. R., Benemei, S., Coppi, E., De Logu, F., Di Tommaso, M., Fusi, C., Geppetti, P., Li Puma, S., Marone, I. M., Materazzi, S., Moneti, G., Nassini, R., Susini, T., Terreni, A., & Tonello, R. (2016). TRPA1 mediates aromatase inhibitor-evoked pain by the aromatase substrate androstenedione. Cancer Research, 76(23), 7024-7035. https://doi.org/10.1158/0008-5472.CAN-16-1492

Aromatase inhibitors (AI) induce painful musculoskeletal symptoms (AIMSS), which are dependent upon the pain transducing receptor TRPA1. However, as the AI concentrations required to engage TRPA1 in mice are higher than those found in the plasma of p... Read More about TRPA1 mediates aromatase inhibitor-evoked pain by the aromatase substrate androstenedione.

Could Fractional Exhaled Nitric Oxide Test be Useful in Predicting Inhaled Corticosteroid Responsiveness in Chronic Cough? A Systematic Review (2016)
Journal Article
Song, W.-J., Won, H.-K., Moon, S.-D., Chung, S.-J., Kang, S.-Y., Sohn, K.-H., Kim, J.-Y., Kim, B.-K., Lim, K.-H., Kim, M.-Y., Yang, M.-S., Park, H.-W., Chang, Y.-S., Lee, B.-J., Morice, A. H., & Cho, S.-H. (2017). Could Fractional Exhaled Nitric Oxide Test be Useful in Predicting Inhaled Corticosteroid Responsiveness in Chronic Cough? A Systematic Review. The journal of allergy and clinical immunology. In practice, 5(1), 135-143.e1. https://doi.org/10.1016/j.jaip.2016.07.017

© 2016 Background Fractional exhaled nitric oxide (FENO) is a safe and convenient test for assessing T H 2 airway inflammation, which is potentially useful in the management of patients with chronic cough. Objective To summarize the current evidence... Read More about Could Fractional Exhaled Nitric Oxide Test be Useful in Predicting Inhaled Corticosteroid Responsiveness in Chronic Cough? A Systematic Review.

Comprehensive evidence-based review on European antitussives (2016)
Journal Article
Morice, A., & Kardos, P. (2016). Comprehensive evidence-based review on European antitussives. BMJ Open Respiratory Research, 3(1), Article e000137. https://doi.org/10.1136/bmjresp-2016-000137

© 2016 BMJ Publishing Group. All rights reserved. Acute cough caused by viral respiratory tract infections is probably the most common illness to afflict mankind. Despite the widespread but ineffective prescribing of antibiotics, there is no specific... Read More about Comprehensive evidence-based review on European antitussives.

Ivacaftor and symptoms of extra-oesophageal reflux in patients with cystic fibrosis and G551D mutation (2016)
Journal Article
Zeybel, G. L., Pearson, J. P., Krishnan, A., Bourke, S. J., Doe, S., Anderson, A., Faruqi, S., Morice, A. H., Jones, R., McDonnell, M., Zeybel, M., Dettmar, P. W., Brodlie, M., & Ward, C. (2017). Ivacaftor and symptoms of extra-oesophageal reflux in patients with cystic fibrosis and G551D mutation. Journal of Cystic Fibrosis, 16(1), 124-131. https://doi.org/10.1016/j.jcf.2016.07.004

© 2016 The Authors Background Extra-oesophageal reflux (EOR) may lead to microaspiration in patients with cystic fibrosis (CF), a probable cause of deteriorating lung function. Successful clinical trials of ivacaftor highlight opportunities to unders... Read More about Ivacaftor and symptoms of extra-oesophageal reflux in patients with cystic fibrosis and G551D mutation.