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On the definition of chronic cough and current treatment pathways: An international qualitative study (2014)
Journal Article
Faruqi, S., Murdoch, R. D., Allum, F., & Morice, A. H. (2014). On the definition of chronic cough and current treatment pathways: An international qualitative study. Cough, 10(1), Article 5. https://doi.org/10.1186/1745-9974-10-5

Background: The pathogenesis of chronic cough is not well understood and treatment options are limited. In this study we sought to explore the current understanding and management of chronic cough across an international group of specialists.Methods:... Read More about On the definition of chronic cough and current treatment pathways: An international qualitative study.

Antitussive drugs-past, present, and future (2014)
Journal Article
Dicpinigaitis, P. V., Morice, A. H., Birring, S. S., McGarvey, L., Smith, J. A., Canning, B. J., & Page, C. P. (2014). Antitussive drugs-past, present, and future. Pharmacological Reviews, 66(2), 468-512. https://doi.org/10.1124/pr.111.005116

Cough remains a serious unmet clinical problem, both as a symptom of a range of other conditions such as asthma, chronic obstructive pulmonary disease, gastroesophageal reflux, and as a problem in its own right in patients with chronic cough of unkno... Read More about Antitussive drugs-past, present, and future.

The effect of deep hypothermia on the human pulmonary circulation (2014)
Journal Article
Ariyaratnam, P., Loubani, M., Cale, A. R., Chaudhry, M., Cowen, M. E., Jarvis, M. A., Griffin, S., & Morice, A. H. (2014). The effect of deep hypothermia on the human pulmonary circulation. Journal of Thermal Biology, 40(1), 20-24. https://doi.org/10.1016/j.jtherbio.2014.01.001

Objective: Acute rises in pulmonary artery pressures following complex cardiac surgery are associated with high morbidity and mortality. We hypothesised that periods of deep hypothermia predispose to elevated pulmonary pressures upon rewarming. We in... Read More about The effect of deep hypothermia on the human pulmonary circulation.

Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis. (2014)
Journal Article
Fahim, A., Crooks, M. G., Morice, A. H., & Hart, S. P. (2014). Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis. Lung, 192(2), 277-284. https://doi.org/10.1007/s00408-013-9546-5

Purpose Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonia and its prognosis is poor. Epidemiological evidence suggests an association of IPF with vascular disease and thrombotic tendency, which may be related to... Read More about Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis..

Dietary intervention in the treatment of patients with cough and symptoms suggestive of airways reflux as determined by Hull airways Reflux Questionnaire (2013)
Journal Article
Smith, J. E., Morjaria, J. B., & Morice, A. H. (2013). Dietary intervention in the treatment of patients with cough and symptoms suggestive of airways reflux as determined by Hull airways Reflux Questionnaire. Cough, 9(1), Article 27. https://doi.org/10.1186/1745-9974-9-27

Background: Chronic cough is a common and distressing symptom. Gastro-oesophageal reflux is a common cause of chronic cough however the symptom complex in cough is not confined to classic peptic symptoms. Dyspeptic symptoms have previously been shown... Read More about Dietary intervention in the treatment of patients with cough and symptoms suggestive of airways reflux as determined by Hull airways Reflux Questionnaire.

Cough in the Elderly Population: Relationships with Multiple Comorbidity (2013)
Journal Article
Song, W. J., Morice, A. H., Kim, M. H., Lee, S. E., Jo, E. J., Lee, S. M., Han, J. W., Kim, T. H., Kim, S. H., Jang, H. C., Kim, K. W., Cho, S. H., Min, K. U., & Chang, Y. S. (2013). Cough in the Elderly Population: Relationships with Multiple Comorbidity. PLoS ONE, 8(10), Article e78081. https://doi.org/10.1371/journal.pone.0078081

Background:The epidemiology of cough in the elderly population has not been studied comprehensively. The present study aimed to investigate the epidemiology of cough in a community elderly population, particularly in relation with their comorbidity.M... Read More about Cough in the Elderly Population: Relationships with Multiple Comorbidity.

Hydrogen sulphide vasodilates human pulmonary arteries: A possible role in pulmonary hypertension? (2013)
Journal Article
Ariyaratnam, P., Loubani, M., & Morice, A. H. (2013). Hydrogen sulphide vasodilates human pulmonary arteries: A possible role in pulmonary hypertension?. Microvascular Research, 90, 135-137. https://doi.org/10.1016/j.mvr.2013.09.002

Introduction: Acute rises in pulmonary artery pressures are associated with a significant mortality and morbidity due to the significant strain on the right ventricle. Although hydrogen sulphide (H2S) has been studied for its potential role in the sy... Read More about Hydrogen sulphide vasodilates human pulmonary arteries: A possible role in pulmonary hypertension?.

Hypoxic pulmonary vasoconstriction in humans (2013)
Journal Article
Ariyaratnam, P., Loubani, M., & Morice, A. H. (2013). Hypoxic pulmonary vasoconstriction in humans. Biomed research international, 2013, Article 623684. https://doi.org/10.1155/2013/623684

Hypoxic pulmonary vasoconstriction is the elegant theory put forward more than six decades ago to explain regional variations in perfusion within the lung in certain animal species in response to localised restrictions in oxygenation. Although consid... Read More about Hypoxic pulmonary vasoconstriction in humans.

Airway reflux as a cause of respiratory disease (2013)
Journal Article
Morice, A. H. (2013). Airway reflux as a cause of respiratory disease. Breathe, 9(4), 257-266. https://doi.org/10.1183/20734735.000513

Reflux is the cause of much respiratory disease. More commonly still, it is the unrecognised agent provoking the symptoms of respiratory disease. That the reflux entering the airways from the gastrointestinal tract is central to the diagnosis, therap... Read More about Airway reflux as a cause of respiratory disease.

Symptoms of airway reflux predict exacerbations and quality of life in bronchiectasis (2013)
Journal Article
Mandal, P., Morice, A. H., Chalmers, J. D., & Hill, A. T. (2013). Symptoms of airway reflux predict exacerbations and quality of life in bronchiectasis. Respiratory medicine, 107(7), 1008-1013. https://doi.org/10.1016/j.rmed.2013.04.006

Aim We have explored the association of the upper airway symptoms related to cough with exacerbation frequency, sputum microbiology and inflammatory markers in patients with non cystic fibrosis bronchiectasis. Methods Patients with bronchiectasis com... Read More about Symptoms of airway reflux predict exacerbations and quality of life in bronchiectasis.

Chronic cough hypersensitivity syndrome (2013)
Journal Article
Morice, A. H. (2013). Chronic cough hypersensitivity syndrome. Cough, 9(1), Article 14. https://doi.org/10.1186/1745-9974-9-14

Chronic cough has been suggested to be due to three conditions, asthma, post nasal drip, and reflux disease. A different paradigm has evolved in which cough is viewed as the primary condition characterised by afferent neuronal hypersensitivity and di... Read More about Chronic cough hypersensitivity syndrome.

Management of patients with chronic cough using a clinical protocol: A prospective observational study (2013)
Journal Article
Ojoo, O. C., Everett, C. F., Mulrennan, S. A., Faruqi, S., Kastelik, J. A., & Morice, A. H. (2013). Management of patients with chronic cough using a clinical protocol: A prospective observational study. Cough, 9(1), Article 2. https://doi.org/10.1186/1745-9974-9-2

Background and aims: Chronic cough is a common symptom the aetiology of which can be challenging to diagnose. Diagnostic protocols for chronic cough have required the use of specialist investigations which are not always easily available. We wanted t... Read More about Management of patients with chronic cough using a clinical protocol: A prospective observational study.

Novel antitussive strategies (2012)
Journal Article
Morjaria, J. B., Dickinson, R. S., & Morice, A. H. (2013). Novel antitussive strategies. Drug Discovery Today, 18(7-8), 380-388. https://doi.org/10.1016/j.drudis.2012.11.004

Acute and chronic cough represent one of the most common symptoms of medical importance but effective pharmacotherapy is, to all intents and purposes, absent. Numerous initiatives targeting the recently discovered tussive pathways are in progress. He... Read More about Novel antitussive strategies.

Serum carcinoembryonic antigen correlates with severity of idiopathic pulmonary fibrosis (2012)
Journal Article
Fahim, A., Crooks, M., Wilmot, R., Campbell, A. P., Morice, A., & Hart, S. (2012). Serum carcinoembryonic antigen correlates with severity of idiopathic pulmonary fibrosis. Respirology : official journal of the Asian Pacific Society of Respirology, 17(8), 1247-1252. https://doi.org/10.1111/j.1440-1843.2012.02231.x

Background and objective: Idiopathic pulmonary fibrosis (IPF) is the commonest idiopathic interstitial pneumonia and carries a poor prognosis. Epidemiological evidence suggests that patients with IPF have an increased risk of developing lung cancer.... Read More about Serum carcinoembryonic antigen correlates with severity of idiopathic pulmonary fibrosis.

Chronic Cough in Musculoskeletal disorders: Using high resolution oesophageal manometry in search of an Aetiology (2012)
Journal Article
Pathmanathan, S., Morjaria, J. B., Morice, A. H., & Jackson, W. (2012). Chronic Cough in Musculoskeletal disorders: Using high resolution oesophageal manometry in search of an Aetiology. Cough, 8(1), Article 6. https://doi.org/10.1186/1745-9974-8-6

Chronic cough is a common symptom carrying significant morbidity which can occur as a result of oesophageal dysmotility. Here we report 2 patients with musculoskeletal disease presenting with chronic cough to our tertiary cough clinic. Prior to refer... Read More about Chronic Cough in Musculoskeletal disorders: Using high resolution oesophageal manometry in search of an Aetiology.

Fundoplication in chronic intractable cough (2012)
Journal Article
Faruqi, S., Sedman, P., Jackson, W., Molyneux, I., & Morice, A. H. (2012). Fundoplication in chronic intractable cough. Cough, 8(1), Article 3. https://doi.org/10.1186/1745-9974-8-3

Background: Airway reflux is a common cause of chronic cough and this is often refractory to medical therapy. Surgery in the form of Nissen fundoplication has been highly successful in the treatment of the classic reflux symptoms of heartburn and dys... Read More about Fundoplication in chronic intractable cough.