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Limited role for ivabradine in the treatment of chronic heart failure (2011)
Journal Article
Cullington, D., Goode, K. M., Cleland, J. G. F., & Clark, A. L. (2011). Limited role for ivabradine in the treatment of chronic heart failure. Heart, 97(23), 1961-1966. https://doi.org/10.1136/heartjnl-2011-300041

ObjectiveTo quantify the proportion of patients attending a community heart failure clinic with left ventricular systolic impairment who might be suitable for ivabradine therapy.BackgroundHigh resting heart rate is an important and potentially modifi... Read More about Limited role for ivabradine in the treatment of chronic heart failure.

Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure (2010)
Journal Article
Shelton, R. J., Ingle, L., Rigby, A. S., Witte, K. K., Cleland, J. G., & Clark, A. L. (2010). Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure. European journal of heart failure, 12(9), 983-989. https://doi.org/10.1093/eurjhf/hfq086

Aims Mechanisms of exercise limitation in patients with chronic heart failure (CHF) are incompletely understood. During matched submaximal, fixed-rate exercise, oxygen uptake is similar in patients and healthy controls. However, the importance of ca... Read More about Cardiac output does not limit submaximal exercise capacity in patients with chronic heart failure.

Lack of diastolic reserve in patients with heart failure and normal ejection fraction (2009)
Journal Article
Chattopadhyay, S., Alamgir, M. F., Nikitin, N. P., Rigby, A. S., Clark, A. L., & Cleland, J. G. F. (2010). Lack of diastolic reserve in patients with heart failure and normal ejection fraction. Circulation. Heart failure, 3(1), 35-43. https://doi.org/10.1161/CIRCHEARTFAILURE.108.824888

Background-The genesis of symptoms in patients with heart failure (HF) and normal ejection fraction (HFNEF) is unclear. Most investigations of HFNEF have focused on cardiac function at rest although most of these patients are breathless only on exerc... Read More about Lack of diastolic reserve in patients with heart failure and normal ejection fraction.

Low dose cabergoline for hyperprolactinaemia is not associated with clinically significant valvular heart disease (2008)
Journal Article
Wakil, A., Rigby, A. S., Clark, A. L., Kallvikbacka-Bennett, A., & Atkin, S. L. (2008). Low dose cabergoline for hyperprolactinaemia is not associated with clinically significant valvular heart disease. European journal of endocrinology, 159(4), R11-R14. https://doi.org/10.1530/eje-08-0365

OBJECTIVE: Recent trials suggest that using ergot-derived dopamine agonists such as cabergoline in the treatment of Parkinson's disease is associated with an increased risk of valvular heart disease. However, the dose of cabergoline used to treat hyp... Read More about Low dose cabergoline for hyperprolactinaemia is not associated with clinically significant valvular heart disease.

The timing of development and subsequent clinical course of heart failure after a myocardial infarction (2008)
Journal Article
Torabi, A., Cleland, J. G., Khan, N. K., Loh, P. H., Clark, A. L., Alamgir, F., Caplin, J. L., Rigby, A. S., & Goode, K. (2008). The timing of development and subsequent clinical course of heart failure after a myocardial infarction. European Heart Journal, 29(7), 859-870. https://doi.org/10.1093/eurheartj/ehn096

Aims: Myocardial infarction (MI) is a common cause of heart failure (HF), which may develop early and persist or resolve, or develop late. The cumulative incidence, persistence, and resolution of HF after MI are poorly described. The aim of this stud... Read More about The timing of development and subsequent clinical course of heart failure after a myocardial infarction.

Changes in body composition in patients with left ventricular systolic dysfunction initiated on beta-blocker therapy (2007)
Journal Article
Ingle, L., Rigby, A. S., Carroll, S., Butterly, R., King, R. F., Cooke, C. B., Cleland, J. G., & Clark, A. L. (2007). Changes in body composition in patients with left ventricular systolic dysfunction initiated on beta-blocker therapy. Experimental and Clinical Cardiology, 12(1), 46-47

Background: Increasing body mass index, cholesterol and body fat are associated with a better prognosis in patients with left ventricular systolic dysfunction (LVSD). Beta-blocker usage is associated with changes in body composition and increased bod... Read More about Changes in body composition in patients with left ventricular systolic dysfunction initiated on beta-blocker therapy.

Prognostic value of the 6 min walk test and self-perceived symptom severity in older patients with chronic heart failure (2007)
Journal Article
Ingle, L., Rigby, A. S., Carroll, S., Butterly, R., King, R. F., Cooke, C. B., Cleland, J. G., & Clark, A. L. (2007). Prognostic value of the 6 min walk test and self-perceived symptom severity in older patients with chronic heart failure. European Heart Journal, 28(5), 560-568. https://doi.org/10.1093/eurheartj/ehl527

Background: The 6 min walk test (6-MWT) is a simple and popular test for evaluating functional status in patients with chronic heart failure (CHF). However, the prognostic value of the 6-MWT in a large, representative sample of CHF patients, and in p... Read More about Prognostic value of the 6 min walk test and self-perceived symptom severity in older patients with chronic heart failure.

Clinical determinants of poor six-minute walk test performance in patients with left ventricular systolic dysfunction and no major structural heart disease (2006)
Journal Article
Ingle, L., Rigby, A. S., Nabb, S., Jones, P. K., Clark, A. L., & Cleland, J. G. (2006). Clinical determinants of poor six-minute walk test performance in patients with left ventricular systolic dysfunction and no major structural heart disease. European journal of heart failure, 8(3), 321-325. https://doi.org/10.1016/j.ejheart.2005.08.006

Background: The clinical determinants of six-minute walk test (6-MWT) performance in patients with left ventricular systolic dysfunction (LVSD) have rarely been investigated, and it is not clear whether they differ from patients referred for the asse... Read More about Clinical determinants of poor six-minute walk test performance in patients with left ventricular systolic dysfunction and no major structural heart disease.

The reproducibility and sensitivity of the 6-min walk test in elderly patients with chronic heart failure (2005)
Journal Article
Ingle, L., Shelton, R. J., Rigby, A. S., Nabb, S., Clark, A. L., & Cleland, J. G. (2005). The reproducibility and sensitivity of the 6-min walk test in elderly patients with chronic heart failure. European Heart Journal, 26(17), 1742-1751. https://doi.org/10.1093/eurheartj/ehi259

Aims: The 6-min walk test (6-MWT) is used to estimate functional capacity. However, in elderly patients with chronic heart failure (CHF): (i) 1 year reproducibility of the 6-MWT; (ii) sensitivity of the 6-MWT to self-perceived changes in symptoms of... Read More about The reproducibility and sensitivity of the 6-min walk test in elderly patients with chronic heart failure.