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Outcomes in patients treated with loop diuretics without a diagnosis of heart failure: a retrospective cohort study (2024)
Journal Article
Cuthbert, J. J., Soyiri, I., Lomax, S. J., Turgoose, J., Fuat, A., Cohen, J., & Clark, A. L. (2024). Outcomes in patients treated with loop diuretics without a diagnosis of heart failure: a retrospective cohort study. Heart, 110(12), 854-862. https://doi.org/10.1136/heartjnl-2023-323577

Background Loop diuretics are commonly prescribed in the community, not always to patients with a recorded diagnosis of heart failure (HF). The rate of HF events in patients prescribed loop diuretics without a diagnosis of HF is unknown. Methods This... Read More about Outcomes in patients treated with loop diuretics without a diagnosis of heart failure: a retrospective cohort study.

Hospital admissions in the last year of life of patients with heart failure (2024)
Journal Article
AI Abel, A., Samuel, N. A., Cuthbert, J. J., Brown, O. I., Pellicori, P., Kazmi, S., GF Cleland, J., Johnson, M., & Clark, A. L. (2024). Hospital admissions in the last year of life of patients with heart failure. European Heart Journal - Quality of Care and Clinical Outcomes, 10(2), 168-175. https://doi.org/10.1093/ehjqcco/qcad047

Aim To explore the frequency, causes, and pattern of hospitalisation for patients with chronic heart failure (HF) in the 12 months preceding death. We also investigated cause of death. Methods Patients referred to a secondary care HF clinic were rout... Read More about Hospital admissions in the last year of life of patients with heart failure.

Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions – Part I: Loop Diuretics (2024)
Journal Article
Cuthbert, J. J., & Clark, A. L. (2024). Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions – Part I: Loop Diuretics. Current Heart Failure Reports, 21(2), 101-114. https://doi.org/10.1007/s11897-024-00643-3

Purpose of Review: Fluid retention or congestion is a major cause of symptoms, poor quality of life, and adverse outcome in patients with heart failure (HF). Despite advances in disease-modifying therapy, the mainstay of treatment for congestion—loop... Read More about Diuretic Treatment in Patients with Heart Failure: Current Evidence and Future Directions – Part I: Loop Diuretics.

Are non-invasive estimations of plasma volume an accurate measure of congestion in patients with chronic heart failure? (2023)
Journal Article
Cuthbert, J. J., Pellicori, P., Rigby, A. S., Abel, A. A., Kalvickbacka-Bennet, A., Shah, P., Kearsley, J. W., Kazmi, S., Cleland, J. G., & Clark, A. L. (2023). Are non-invasive estimations of plasma volume an accurate measure of congestion in patients with chronic heart failure?. European Heart Journal - Quality of Care and Clinical Outcomes, 9(3), 281-292. https://doi.org/10.1093/ehjqcco/qcac035

Aims: We report associations between different formulae for estimating plasma volume status (PVS) and clinical and ultrasound markers of congestion in patients with chronic heart failure (CHF) enrolled in the Hull Lifelab registry. Methods and result... Read More about Are non-invasive estimations of plasma volume an accurate measure of congestion in patients with chronic heart failure?.

Inferior vena cava diameter is associated with prognosis in patients with chronic heart failure independent of tricuspid regurgitation velocity (2023)
Journal Article
Iaconelli, A., Cuthbert, J., Kazmi, S., Maffia, P., Clark, A. L., Cleland, J. G., & Pellicori, P. (2023). Inferior vena cava diameter is associated with prognosis in patients with chronic heart failure independent of tricuspid regurgitation velocity. Clinical Research in Cardiology, 112(8), 1077-1086. https://doi.org/10.1007/s00392-023-02178-4

Aims: A high, Doppler-derived, tricuspid regurgitation velocity (TRV) indicates pulmonary hypertension, which may contribute to right ventricular dysfunction and worsening tricuspid regurgitation leading to systemic venous congestion, reflected by an... Read More about Inferior vena cava diameter is associated with prognosis in patients with chronic heart failure independent of tricuspid regurgitation velocity.

Dynamic risk stratification using Markov chain modelling in patients with chronic heart failure (2022)
Journal Article
Kazmi, S., Kambhampati, C., Cleland, J., Cuthbert, J., Kazmi, K. S., Pellicori, P., …Clark, A. L. (2022). Dynamic risk stratification using Markov chain modelling in patients with chronic heart failure. ESC Heart Failure, https://doi.org/10.1002/ehf2.14028

Aims: Risk changes with the progression of disease and the impact of treatment. We developed a dynamic risk stratification Markov chain model using artificial intelligence in patients with chronic heart failure (CHF). Methods and results: We describe... Read More about Dynamic risk stratification using Markov chain modelling in patients with chronic heart failure.

Biomarker‐based assessment of collagen cross‐linking identifies patients at risk of heart failure more likely to benefit from spironolactone effects on left atrial remodelling (2021)
Journal Article
Ravassa, S., López, B., Ferreira, J. P., Girerd, N., Bozec, E., Pellicori, P., Mariottoni, B., Cosmi, F., Hazebroek, M., Verdonschot, J. A., Cuthbert, J., Petutschnigg, J., Moreno, M. U., Heymans, S., Staessen, J. A., Pieske, B., Edelmann, F., Clark, A. L., Cleland, J. G., Zannad, F., …HOMAGE Trial Committees and Investigators. (2022). Biomarker‐based assessment of collagen cross‐linking identifies patients at risk of heart failure more likely to benefit from spironolactone effects on left atrial remodelling. European journal of heart failure, 24(2), 321-331. https://doi.org/10.1002/ejhf.2394

Aims
The HOMAGE randomized trial found that spironolactone reduced left atrial volume index (LAVI), E:A ratio, and a marker of collagen type I synthesis (procollagen type I C-terminal propeptide) in patients at risk of heart failure (HF). Previous t... Read More about Biomarker‐based assessment of collagen cross‐linking identifies patients at risk of heart failure more likely to benefit from spironolactone effects on left atrial remodelling.

The effect of spironolactone on cardiovascular function and markers of fibrosis in people at increased risk of developing heart failure: the heart 'OMics' in AGEing (HOMAGE) randomized clinical trial (2020)
Journal Article
Cleland, J. G. F., Pedro Ferreira, J., Mariottoni, B., Pellicori, P., Cuthbert, J., Verdonschot, J. A. J., Petutschnigg, J., Ahmed, F. Z., Cosmi, F., Brunner La Rocca, H.-P., Mamas, M. A., Clark, A. L., Edelmann, F., Pieske, B., Khan, J., McDonald, K., Rouet, P., Staessen, J. A., Mujaj, B., González, A., …the HOMAGE Trial Committees and Investigators. (2021). The effect of spironolactone on cardiovascular function and markers of fibrosis in people at increased risk of developing heart failure: the heart 'OMics' in AGEing (HOMAGE) randomized clinical trial. European Heart Journal, 42(6), 684–696. https://doi.org/10.1093/eurheartj/ehaa758

Aims: To investigate the effects of spironolactone on fibrosis and cardiac function in people at increased risk of developing heart failure.
Methods and results: Randomized, open-label, blinded-endpoint trial comparing spironolactone (50 mg/day) or... Read More about The effect of spironolactone on cardiovascular function and markers of fibrosis in people at increased risk of developing heart failure: the heart 'OMics' in AGEing (HOMAGE) randomized clinical trial.

Relation Between Thyroid Function and Mortality in Patients With Chronic Heart Failure (2020)
Journal Article
Samuel, N. A., Cuthbert, J. J., Brown, O. I., Kazmi, S., Cleland, J. G., Rigby, A. S., & Clark, A. L. (2021). Relation Between Thyroid Function and Mortality in Patients With Chronic Heart Failure. The American journal of cardiology, 139, 57-63. https://doi.org/10.1016/j.amjcard.2020.10.034

Thyroid dysfunction is common in patients with chronic heart failure (CHF), but there is conflicting evidence regarding its prognostic significance. We investigated the relation between thyroid function and prognosis in a large, well characterized co... Read More about Relation Between Thyroid Function and Mortality in Patients With Chronic Heart Failure.

Hypochloraemia in Patients with Heart Failure: Causes and Consequences (2020)
Journal Article
Cuthbert, J. J., Bhandari, S., & Clark, A. L. (2020). Hypochloraemia in Patients with Heart Failure: Causes and Consequences. Cardiology and Therapy, 9, 333-347. https://doi.org/10.1007/s40119-020-00194-3

Hypochloraemia is a common electrolyte abnormality in patients with heart failure (HF). It has a strong association with adverse outcome regardless of HF phenotype and independent of other prognostic markers. How hypochloraemia develops in a patient... Read More about Hypochloraemia in Patients with Heart Failure: Causes and Consequences.

Cardiovascular Outcomes with Sacubitril-Valsartan in Heart Failure: Emerging Clinical Data (2020)
Journal Article
Cuthbert, J. J., Pellicori, P., & Clark, A. L. (2020). Cardiovascular Outcomes with Sacubitril-Valsartan in Heart Failure: Emerging Clinical Data. Therapeutics and Clinical Risk Management, 16, 715-726. https://doi.org/10.2147/tcrm.s234772

One of the defining features of heart failure (HF) is neurohormonal activation. The renin-angiotensin-aldosterone-system (RAAS) and sympathetic nervous system (SNS) cause vasoconstriction and fluid retention and, in response, the secretion of natriur... Read More about Cardiovascular Outcomes with Sacubitril-Valsartan in Heart Failure: Emerging Clinical Data.

Prevalence and incidence of atrial fibrillation in ambulatory patients with heart failure (2019)
Journal Article
Pellicori, P., Urbinati, A., Kaur, K., Zhang, J., Shah, P., Kazmi, S., …Clark, A. L. (2019). Prevalence and incidence of atrial fibrillation in ambulatory patients with heart failure. The American journal of cardiology, 124(10), 1554-1560. https://doi.org/10.1016/j.amjcard.2019.08.018

Heart failure (HF) and atrial fibrillation (AF) commonly co-exist. We aimed to determine the prevalence and incidence of AF in ambulatory patients with HF. HF was defined by the presence of symptoms or signs supported by objective evidence of cardiac... Read More about Prevalence and incidence of atrial fibrillation in ambulatory patients with heart failure.

High-sensitivity C-reactive protein in chronic heart failure: Patient characteristics, phenotypes, and mode of death (2019)
Journal Article
Pellicori, P., Zhang, J., Cuthbert, J., Urbinati, A., Shah, P., Kazmi, S., Clark, A. L., & Cleland, J. G. (2020). High-sensitivity C-reactive protein in chronic heart failure: Patient characteristics, phenotypes, and mode of death. Cardiovascular research, 116(1), 91-100. https://doi.org/10.1093/cvr/cvz198

Aims: Plasma concentrations of high-sensitivity C-reactive protein (hsCRP) are often raised in chronic heart failure (CHF) and might indicate inflammatory processes that could be a therapeutic target. We aimed to study the associations between hsCRP,... Read More about High-sensitivity C-reactive protein in chronic heart failure: Patient characteristics, phenotypes, and mode of death.

Characteristics and outcome of acute heart failure patients according to the severity of peripheral oedema (2019)
Journal Article
Shoaib, A., Mamas, M. A., Ahmad, Q. S., McDonagh, T. M., Hardman, S. M., Rashid, M., Butler, R., Duckett, S., Satchithananda, D., Nolan, J., Dargie, H. J., Clark, A. L., & Cleland, J. G. (2019). Characteristics and outcome of acute heart failure patients according to the severity of peripheral oedema. International journal of cardiology, 285, 40-46. https://doi.org/10.1016/j.ijcard.2019.03.020

Background: Most trials of patients hospitalized for heart failure focus on breathlessness (alveolar pulmonary oedema) but worsening peripheral oedema is also an important presentation. We investigated the relationship between the severity of periphe... Read More about Characteristics and outcome of acute heart failure patients according to the severity of peripheral oedema.

Prevalence, pattern and clinical relevance of ultrasound indices of congestion in outpatients with heart failure (2019)
Journal Article
Pellicori, P., Shah, P., Cuthbert, J., Urbinati, A., Zhang, J., Kallvikbacka-Bennett, A., Clark, A. L., & Cleland, J. G. F. (2019). Prevalence, pattern and clinical relevance of ultrasound indices of congestion in outpatients with heart failure. European journal of heart failure, 21(7), 904-916. https://doi.org/10.1002/ejhf.1383

Aims: Even if treatment controls symptoms, patients with heart failure may still be congested. We aimed at assessing the prevalence and clinical relevance of congestion in outpatients with chronic heart failure. Methods and results: We recorded clini... Read More about Prevalence, pattern and clinical relevance of ultrasound indices of congestion in outpatients with heart failure.

Are there patients missing from community heart failure registers? An audit of clinical practice (2018)
Journal Article
Cuthbert, J. J., Gopal, J., Crundall-Goode, A., & Clark, A. L. (2019). Are there patients missing from community heart failure registers? An audit of clinical practice. European Journal of Preventive Cardiology, 26(3), 291-298. https://doi.org/10.1177/2047487318810839

Background: General practitioners in the UK are financially incentivised, via the Quality Outcomes Framework, to maintain a record of all patients at their practice with heart failure and manage them appropriately. The prevalence of heart failure rec... Read More about Are there patients missing from community heart failure registers? An audit of clinical practice.

Mode of presentation and mortality amongst patients hospitalized with heart failure? A report from the First Euro Heart Failure Survey (2018)
Journal Article
Shoaib, A., Farag, M., Nolan, J., Rigby, A., Patwala, A., Rashid, M., Kwok, C. S., Perveen, R., Clark, A., Komajda, M., & Cleland, J. G. (2019). Mode of presentation and mortality amongst patients hospitalized with heart failure? A report from the First Euro Heart Failure Survey. Clinical Research in Cardiology, 108(5), 510-519. https://doi.org/10.1007/s00392-018-1380-6

© 2018, The Author(s). Background: Heart failure is heterogeneous in aetiology, pathophysiology, and presentation. Despite this diversity, clinical trials of patients hospitalized for HF deal with this problem as a single entity, which may be one rea... Read More about Mode of presentation and mortality amongst patients hospitalized with heart failure? A report from the First Euro Heart Failure Survey.

Warm water immersion in patients with chronic heart failure: a pilot study: Shah immerse: HF (2018)
Journal Article
Shah, P., Pellicori, P., Kallvikbacka-Bennett, A., Zhang, J., Pan, D., & Clark, A. L. (2019). Warm water immersion in patients with chronic heart failure: a pilot study: Shah immerse: HF. Clinical Research in Cardiology, 108(5), 468–476. https://doi.org/10.1007/s00392-018-1376-2

Background
Patients with chronic conditions, such as heart failure, swim regularly and most rehabilitation exercises are conducted in warm hydrotherapy pools. However, little is known about the acute effects of warm water immersion (WWI) on cardiac... Read More about Warm water immersion in patients with chronic heart failure: a pilot study: Shah immerse: HF.

The impact of heart failure and chronic obstructive pulmonary disease on mortality in patients presenting with breathlessness (2018)
Journal Article
Cuthbert, J. J., Kearsley, J. W., Kazmi, S., Kallvikbakka-Bennett, A., Weston, J., Davis, J., Rimmer, S., & Clark, A. L. (2019). The impact of heart failure and chronic obstructive pulmonary disease on mortality in patients presenting with breathlessness. Clinical Research in Cardiology, 108(2), 185–193. https://doi.org/10.1007/s00392-018-1342-z

© 2018, The Author(s). Background: Differentiating heart failure from chronic obstructive pulmonary disease (COPD) in a patient presenting with breathlessness is difficult but may have implications for outcome. We investigated the prognostic impact o... Read More about The impact of heart failure and chronic obstructive pulmonary disease on mortality in patients presenting with breathlessness.