All Outputs (4)

Differential induction of cellular proliferation, hypertrophy and apoptosis in H9c2 cardiomyocytes by exogenous tissue factor (2010)
Journal Article
Alkistis Frentzou, G., Collier, M. E. W., Ettelaie, C., & Seymour, A.-M. L. (2010). Differential induction of cellular proliferation, hypertrophy and apoptosis in H9c2 cardiomyocytes by exogenous tissue factor. Molecular and Cellular Biochemistry, 345(1-2), 119-130. https://doi.org/10.1007/s11010-010-0565-8

Recent evidence has shown that prolonged exposure to exogenous tissue factor (TF) can alter the cellular functions of cardiomyocytes resulting in cardiac dysfunction. The effect of TF may arise from local inflammation within or in the vicinity of the... Read More about Differential induction of cellular proliferation, hypertrophy and apoptosis in H9c2 cardiomyocytes by exogenous tissue factor.

Microfluidic perfusion system for maintaining viable heart tissue with real-time electrochemical monitoring of reactive oxygen species (2010)
Journal Article
Cheah, L.-T., Dou, Y. H., Seymour, A. M. L., Dyer, C. E., Haswell, S. J., Wadhawan, J. D., & Greenman, J. (2010). Microfluidic perfusion system for maintaining viable heart tissue with real-time electrochemical monitoring of reactive oxygen species. Lab on a chip, 10(20), 2720-2726. https://doi.org/10.1039/c004910g

A microfluidic device has been developed to maintain viable heart tissue samples in a biomimetic microenvironment. This device allows rat or human heart tissue to be studied under pseudo in vivo conditions. Effluent levels of lactate dehydrogenase an... Read More about Microfluidic perfusion system for maintaining viable heart tissue with real-time electrochemical monitoring of reactive oxygen species.

Uremic cardiomyopathy and insulin resistance: a critical role for Akt? (2010)
Journal Article
Semple, D., Smith, K., Bhandari, S., & Seymour, A. M. L. (2011). Uremic cardiomyopathy and insulin resistance: a critical role for Akt?. Journal of the American Society of Nephrology : JASN, 22(2), 207-215. https://doi.org/10.1681/ASN.2009090900

Uremic cardiomyopathy is a classic complication of chronic renal failure whose cause is unclear and treatment remains disappointing. Insulin resistance is an independent predictor of cardiovascular mortality in chronic renal failure. Underlying insul... Read More about Uremic cardiomyopathy and insulin resistance: a critical role for Akt?.

Functional and metabolic adaptation in uraemic cardiomyopathy (2010)
Journal Article
Smith, K., Semple, D., Aksentijević, D., Bhandari, S., & Seymour, A. L. (2010). Functional and metabolic adaptation in uraemic cardiomyopathy. Frontiers in bioscience (Elite edition), E2(4), 1492-1501. https://doi.org/10.2741/e208

Cardiovascular complications are the leading cause of death in patients with chronic kidney disease (CKD). The uraemic heart undergoes substantial remodelling, including left ventricular hypertrophy (LVH), an important determinant of heart failure. L... Read More about Functional and metabolic adaptation in uraemic cardiomyopathy.