All Outputs (21)

Changes in prevalence and incidence of dementia and risk factors for dementia: an analysis from cohort studies (2024)
Journal Article
Mukadam, N., Wolters, F. J., Walsh, S., Wallace, L., Brayne, C., Matthews, F. E., Sacuiu, S., Skoog, I., Seshadri, S., Beiser, A., Ghosh, S., & Livingston, G. (2024). Changes in prevalence and incidence of dementia and risk factors for dementia: an analysis from cohort studies. The Lancet. Public Health, 9(7), e443-e460. https://doi.org/10.1016/S2468-2667%2824%2900120-8

Background: Some cohort studies have reported a decline in dementia prevalence and incidence over time, although these findings have not been consistent across studies. We reviewed evidence on changes in dementia prevalence and incidence over time us... Read More about Changes in prevalence and incidence of dementia and risk factors for dementia: an analysis from cohort studies.

Differences in trajectories of quality of life according to type of dementia: 6-year longitudinal findings from the IDEAL programme (2024)
Journal Article
Martyr, A., Gamble, L. D., Hunt, A., Quinn, C., Morris, R. G., Henderson, C., Allan, L., Opdebeeck, C., Charlwood, C., Jones, R. W., Pentecost, C., Kopelman, M. D., Thom, J. M., Matthews, F. E., & Clare, L. (2024). Differences in trajectories of quality of life according to type of dementia: 6-year longitudinal findings from the IDEAL programme. BMC medicine, 22(1), Article 265. https://doi.org/10.1186/s12916-024-03492-y

Background: People with different types of dementia may have distinct symptoms and experiences that affect their quality of life. This study investigated whether quality of life varied across types of dementia and over time. Methods: The participants... Read More about Differences in trajectories of quality of life according to type of dementia: 6-year longitudinal findings from the IDEAL programme.

The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction (2024)
Journal Article
Almansouri, T., Waller, R., Wharton, S. B., Heath, P. R., Matthews, F. E., Brayne, C., van Eeden, F., & Simpson, J. E. (2024). The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction. International Journal of Molecular Sciences, 25(8), Article 4445. https://doi.org/10.3390/ijms25084445

Age-associated deep-subcortical white matter lesions (DSCLs) are an independent risk factor for dementia, displaying high levels of CD68+ microglia. This study aimed to characterize the transcriptomic profile of microglia in DSCLs and surrounding rad... Read More about The Microglial Transcriptome of Age-Associated Deep Subcortical White Matter Lesions Suggests a Neuroprotective Response to Blood–Brain Barrier Dysfunction.

Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme (2024)
Journal Article
Sabatini, S., Martyr, A., Hunt, A., Gamble, L. D., Matthews, F. E., Thom, J. M., …Clare, L. (2024). Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme. BMC Geriatrics, 24(1), Article 171. https://doi.org/10.1186/s12877-024-04707-w

Objectives: Longitudinal evidence documenting health conditions in spousal caregivers of people with dementia and whether these influence caregivers’ outcomes is scarce. This study explores type and number of health conditions over two years in careg... Read More about Health conditions in spousal caregivers of people with dementia and their relationships with stress, caregiving experiences, and social networks: longitudinal findings from the IDEAL programme.

Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme (2024)
Journal Article
Sabatini, S., Martyr, A., Hunt, A., Gamble, L. D., Matthews, F. E., Thom, J. M., Jones, R. W., Allan, L., Knapp, M., Victor, C., Pentecost, C., Rusted, J. M., Morris, R. G., & Clare, L. (2024). Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme. BMC Geriatrics, 24(1), Article 23. https://doi.org/10.1186/s12877-023-04601-x

Background: Most people with dementia have multiple health conditions. This study explores (1) number and type of health condition(s) in people with dementia overall and in relation to age, sex, dementia type, and cognition; (2) change in number of h... Read More about Comorbid health conditions and their impact on social isolation, loneliness, quality of life, and well-being in people with dementia: longitudinal findings from the IDEAL programme.

Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme (2023)
Journal Article
Rippon, I., Victor, C. R., Martyr, A., Matthews, F. E., Quinn, C., Rusted, J. M., Jones, R. W., Collins, R., van Horik, J., Pentecost, C., Allan, L., & Clare, L. (in press). Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme. Aging and Mental Health, 1-9. https://doi.org/10.1080/13607863.2023.2286618

Objectives: This study aims to investigate the impact of self and partner experiences of loneliness and social isolation on life satisfaction in people with dementia and their spousal carers. Methods: We used data from 1042 dementia caregiving dyads... Read More about Dyadic perspectives on loneliness and social isolation among people with dementia and spousal carers: findings from the IDEAL programme.

Time trends in neuropathology give clues to dementia risk reduction (2023)
Journal Article
Merrick, R., & Matthews, F. E. (2023). Time trends in neuropathology give clues to dementia risk reduction. Nature Reviews Neurology, 19(7), 389-390. https://doi.org/10.1038/s41582-023-00812-3

A new study sheds light on the declining incidence of dementia by examining trends in neuropathology over time in autopsy results from two large US cohorts. Although the prevalence of neurodegenerative pathologies remained similar, a reduction in the... Read More about Time trends in neuropathology give clues to dementia risk reduction.

Blood pressure lowering and prevention of dementia: an individual patient data meta-analysis (2022)
Journal Article
Peters, R., Xu, Y., Fitzgerald, O., Aung, H. L., Beckett, N., Bulpitt, C., Chalmers, J., Forette, F., Gong, J., Harris, K., Humburg, P., Matthews, F. E., Staessen, J. A., Thijs, L., Tzourio, C., Warwick, J., Woodward, M., & Anderson, C. S. (2022). Blood pressure lowering and prevention of dementia: an individual patient data meta-analysis. European Heart Journal, 43(48), 4980-4990. https://doi.org/10.1093/eurheartj/ehac584

Aims Observational studies indicate U-shaped associations of blood pressure (BP) and incident dementia in older age, but randomized controlled trials of BP-lowering treatment show mixed results on this outcome in hypertensive patients. A pooled indiv... Read More about Blood pressure lowering and prevention of dementia: an individual patient data meta-analysis.

Quantitative checklist for autism in toddlers (Q-CHAT). A population screening study with follow-up: The case for multiple time-point screening for autism (2021)
Journal Article
Allison, C., Matthews, F. E., Ruta, L., Pasco, G., Soufer, R., Brayne, C., Charman, T., & Baron-Cohen, S. (2021). Quantitative checklist for autism in toddlers (Q-CHAT). A population screening study with follow-up: The case for multiple time-point screening for autism. BMJ Paediatrics Open, 5(1), Article e000700. https://doi.org/10.1136/bmjpo-2020-000700

Objective This is a prospective population screening study for autism in toddlers aged 18-30 months old using the Quantitative Checklist for Autism in Toddlers (Q-CHAT), with follow-up at age 4. Design Observational study. Setting Luton, Bedfordshire... Read More about Quantitative checklist for autism in toddlers (Q-CHAT). A population screening study with follow-up: The case for multiple time-point screening for autism.

Trends in life expectancy and healthy life years at birth and age 65 in the UK, 2008–2016, and other countries of the EU28: An observational cross-sectional study (2021)
Journal Article
Welsh, C. E., Matthews, F. E., & Jagger, C. (2021). Trends in life expectancy and healthy life years at birth and age 65 in the UK, 2008–2016, and other countries of the EU28: An observational cross-sectional study. The Lancet Regional Health Europe, 2, Article 100023. https://doi.org/10.1016/j.lanepe.2020.100023

Background: As society ages, promoting the health of the extra years of life is of paramount importance for health, social care and pension provision. Increases in life expectancy in the UK and elsewhere have slowed in recent years, but the reasons f... Read More about Trends in life expectancy and healthy life years at birth and age 65 in the UK, 2008–2016, and other countries of the EU28: An observational cross-sectional study.

Prevalence and factors associated with poor performance in the 5-chair stand test: findings from the Cognitive Function and Ageing Study II and proposed Newcastle protocol for use in the assessment of sarcopenia (2021)
Journal Article
Dodds, R. M., Murray, J. C., Granic, A., Hurst, C., Uwimpuhwe, G., Richardson, S., Brayne, C., Matthews, F. E., Sayer, A. A., Arthur, A., Baldwin, C., Barnes, L. E., Comas-Herrera, A., Dening, T., Forster, G., Harrison, S., Ince, P. G., Jagger, C., McKeith, I. G., Parry, B., …Woods, B. (2021). Prevalence and factors associated with poor performance in the 5-chair stand test: findings from the Cognitive Function and Ageing Study II and proposed Newcastle protocol for use in the assessment of sarcopenia. Journal of Cachexia, Sarcopenia and Muscle, 12(2), 308-318. https://doi.org/10.1002/jcsm.12660

Background: Poor performance in the 5-chair stand test (5-CST) indicates reduced lower limb muscle strength. The 5-CST has been recommended for use in the initial assessment of sarcopenia, the accelerated loss of muscle strength and mass. In order to... Read More about Prevalence and factors associated with poor performance in the 5-chair stand test: findings from the Cognitive Function and Ageing Study II and proposed Newcastle protocol for use in the assessment of sarcopenia.

Dementia in the older population is associated with neocortex content of serum amyloid P component (2021)
Journal Article
Ellmerich, S., Taylor, G. W., Richardson, C. D., Minett, T., Schmidt, A. F., Brayne, C., Matthews, F. E., Ince, P. G., Wharton, S. B., & Pepys, M. B. (2021). Dementia in the older population is associated with neocortex content of serum amyloid P component. Brain Communications, 3(4), Article fcab225. https://doi.org/10.1093/braincomms/fcab225

Despite many reported associations, the direct cause of neurodegeneration responsible for cognitive loss in Alzheimer's disease and some other common dementias is not known. The normal human plasma protein, serum amyloid P component, a constituent of... Read More about Dementia in the older population is associated with neocortex content of serum amyloid P component.

Current and future prevalence estimates of mild cognitive impairment, dementia, and its subtypes in a population-based sample of people 70 years and older in Norway: The HUNT study (2021)
Journal Article
Gjøra, L., Strand, B. H., Bergh, S., Borza, T., Brækhus, A., Engedal, K., Johannessen, A., Kvello-Alme, M., Krokstad, S., Livingston, G., Matthews, F. E., Myrstad, C., Skjellegrind, H., Thingstad, P., Aakhus, E., Aam, S., & Selbæk, G. (2021). Current and future prevalence estimates of mild cognitive impairment, dementia, and its subtypes in a population-based sample of people 70 years and older in Norway: The HUNT study. Journal of Alzheimer's Disease, 79(3), 1213-1226. https://doi.org/10.3233/JAD-201275

Background: Having accurate, up-to-date information on the epidemiology of mild cognitive impairment (MCI) and dementia is imperative. Objective: To determine the prevalence of MCI and dementia in Norway using data from a large population-based study... Read More about Current and future prevalence estimates of mild cognitive impairment, dementia, and its subtypes in a population-based sample of people 70 years and older in Norway: The HUNT study.

Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer’s and small vessel disease pathologies (2020)
Journal Article
Waller, R., Narramore, R., Simpson, J. E., Heath, P. R., Verma, N., Tinsley, M., Barnes, J. R., Haris, H. T., Henderson, F. E., Matthews, F. E., Richardson, C. D., Brayne, C., Ince, P. G., Kalaria, R. N., & Wharton, S. B. (2021). Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer’s and small vessel disease pathologies. Brain Pathology, 31(3), Article e12928. https://doi.org/10.1111/bpa.12928

White matter lesions (WML) are common in the ageing brain, often arising in a field effect of diffuse white matter abnormality. Although WML are associated with cerebral small vessel disease (SVD) and Alzheimer’s disease (AD), their cause and pathoge... Read More about Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer’s and small vessel disease pathologies.

Changes in health and functioning of care home residents over two decades: what can we learn from population-based studies? (2020)
Journal Article
Barker, R. O., Hanratty, B., Kingston, A., Ramsay, S. E., & Matthews, F. E. (2021). Changes in health and functioning of care home residents over two decades: what can we learn from population-based studies?. Age and ageing, 50(3), 921-927. https://doi.org/10.1093/ageing/afaa227

Background: Care home residents have complex care and support needs. There is a perception that the needs of residents have increased, but the evidence is limited. We investigated changes in health and functioning of care home residents over two deca... Read More about Changes in health and functioning of care home residents over two decades: what can we learn from population-based studies?.

Transcriptomic analysis of age-associated periventricular lesions reveals dysregulation of the immune response (2020)
Journal Article
Fadul, M. M., Heath, P. R., Cooper-Knock, J., Kurz, J. M., Al-Azzawi, H. A., Ali, Z., Smith, T., Matthews, F. E., Brayne, C., Wharton, S. B., & Simpson, J. E. (2020). Transcriptomic analysis of age-associated periventricular lesions reveals dysregulation of the immune response. International Journal of Molecular Sciences, 21(21), Article 7924. https://doi.org/10.3390/ijms21217924

White matter lesions (WML) are a common feature of the ageing brain associated with cognitive impairment. The gene expression profiles of periventricular lesions (PVL, n = 7) and radiologically-normal-appearing (control) periventricular white matter... Read More about Transcriptomic analysis of age-associated periventricular lesions reveals dysregulation of the immune response.

Advanced glycation end product formation in human cerebral cortex increases with Alzheimer-type neuropathologic changes but is not independently associated with dementia in a population-derived aging brain cohort (2020)
Journal Article
Chambers, A., Bury, J. J., Minett, T., Richardson, C. D., Brayne, C., Ince, P. G., Shaw, P. J., Garwood, C. J., Heath, P. R., Simpson, J. E., Matthews, F. E., & Wharton, S. B. (2020). Advanced glycation end product formation in human cerebral cortex increases with Alzheimer-type neuropathologic changes but is not independently associated with dementia in a population-derived aging brain cohort. Journal of Neuropathology & Experimental Neurology, 79(9), 950-958. https://doi.org/10.1093/JNEN/NLAA064

Diabetes mellitus is a risk factor for dementia, and nonenzymatic glycosylation of macromolecules results in formation of advanced glycation end-products (AGEs). We determined the variation in AGE formation in brains from the Cognitive Function and A... Read More about Advanced glycation end product formation in human cerebral cortex increases with Alzheimer-type neuropathologic changes but is not independently associated with dementia in a population-derived aging brain cohort.

Cognitive health expectancies of cardiovascular risk factors for cognitive decline and dementia (2020)
Journal Article
Zheng, L., Matthews, F. E., & Anstey, K. J. (2021). Cognitive health expectancies of cardiovascular risk factors for cognitive decline and dementia. Age and ageing, 50(1), 169-175. https://doi.org/10.1093/ageing/afaa111

Background: Cognitive health expectancy estimates the proportion of the lifespan that is lived in good cognitive health at the population level. A number of cardiovascular diseases have been identified to be risk factors for cognitive decline and dem... Read More about Cognitive health expectancies of cardiovascular risk factors for cognitive decline and dementia.

NDRG2 expression correlates with neurofibrillary tangles and microglial pathology in the ageing brain (2020)
Journal Article
Fadul, M. M., Garwood, C. J., Waller, R., Garrett, N., Heath, P. R., Matthews, F. E., Brayne, C., Wharton, S. B., & Simpson, J. E. (2020). NDRG2 expression correlates with neurofibrillary tangles and microglial pathology in the ageing brain. International Journal of Molecular Sciences, 21(1), Article 340. https://doi.org/10.3390/ijms21010340

Astrocytes play a major role in the pathogenesis of a range of neurodegenerative diseases, including Alzheimer’s disease (AD), undergoing dramatic morphological and molecular changes that can cause potentially both beneficial and detrimental effects.... Read More about NDRG2 expression correlates with neurofibrillary tangles and microglial pathology in the ageing brain.

Living Alone with Mild-To-Moderate Dementia: Findings from the IDEAL Cohort (2020)
Journal Article
Clare, L., Martyr, A., Henderson, C., Gamble, L., Matthews, F. E., Quinn, C., Nelis, S. M., Rusted, J., Thom, J., Knapp, M., Hart, N., & Victor, C. (2020). Living Alone with Mild-To-Moderate Dementia: Findings from the IDEAL Cohort. Journal of Alzheimer's Disease, 78(3), 1207-1216. https://doi.org/10.3233/JAD-200638

Background: A significant proportion of people with dementia live alone, but little is known about their specific needs. Objective: To understand the profile of people living alone with mild-to-moderate dementia in the UK and identify any systematic... Read More about Living Alone with Mild-To-Moderate Dementia: Findings from the IDEAL Cohort.