All Outputs (370)

Nonlinear decline of mini-mental state examination in Parkinson's disease (2011)
Journal Article
Aarsland, D., Muniz, G., & Matthews, F. (2011). Nonlinear decline of mini-mental state examination in Parkinson's disease. Movement Disorders, 26(2), 334-337. https://doi.org/10.1002/mds.23416

The trajectory of cognitive functioning in patients with Parkinson's disease (PD) is not known. We used a random change point model to study the individual cognitive trajectory for up to 15 years in a prevalence sample of 238 PD patients, and used th... Read More about Nonlinear decline of mini-mental state examination in Parkinson's disease.

Neuropathological correlates of late-life depression in older people (2011)
Journal Article
Tsopelas, C., Stewart, R., Savva, G. M., Brayne, C., Ince, P., Thomas, A., & Matthews, F. E. (2011). Neuropathological correlates of late-life depression in older people. British Journal of Psychiatry, 198(2), 109-114. https://doi.org/10.1192/bjp.bp.110.078816

Background: Depression is common in old age and is associated with risk of dementia, but its neuropathological correlates in the community are unknown. Aims: To investigate for the first time in a population-representative sample of people with no de... Read More about Neuropathological correlates of late-life depression in older people.

Joint modeling of longitudinal change and survival (2011)
Journal Article
Terrera, G. M., Piccinin, A. M., Johansson, B., Matthews, F., & Hofer, S. M. (2011). Joint modeling of longitudinal change and survival. GeroPsych: The Journal of Gerontopsychology and Geriatric Psychiatry, 24(4), 177-185. https://doi.org/10.1024/1662-9647/a000047

Joint longitudinal-survival models are useful when repeated measures and event time data are available and possibly associated. The application of this joint model in aging research is relatively rare, albeit particularly useful, when there is the po... Read More about Joint modeling of longitudinal change and survival.

Terminal decline from within- and between-person perspectives, accounting for incident dementia (2011)
Journal Article
Piccinin, A. M., Muniz, G., Matthews, F. E., & Johansson, B. (2011). Terminal decline from within- and between-person perspectives, accounting for incident dementia. The Journals of Gerontology, Series B: Psychological Sciences and Social Sciences, 66 B(4), 391-401. https://doi.org/10.1093/geronb/gbr010

Objective. The terminal cognitive decline hypothesis has been debated for almost 50 years. This hypothesis implies a change in rate of decline within an individual. Therefore, we examine the hypothesis from a within-person perspective using a time to... Read More about Terminal decline from within- and between-person perspectives, accounting for incident dementia.

Epidemiological neuropathology: The MRC cognitive function and aging study experience (2011)
Journal Article
Wharton, S. B., Brayne, C., Savva, G. M., Matthews, F. E., Forster, G., Simpson, J., Lace, G., & Ince, P. G. (2011). Epidemiological neuropathology: The MRC cognitive function and aging study experience. Journal of Alzheimer's Disease, 25(2), 359-372. https://doi.org/10.3233/JAD-2011-091402

We here describe the study-design major findings from the neuropathological component of the Medical Research Council Cognitive Function and Aging Study (MRC CFAS). MRC CFAS is a population-representative study of aging and health including more than... Read More about Epidemiological neuropathology: The MRC cognitive function and aging study experience.

A European perspective on population studies of dementia (2011)
Journal Article
Brayne, C., Stephan, B. C., & Matthews, F. E. (2011). A European perspective on population studies of dementia. Alzheimer's & dementia, 7(1), 3-9. https://doi.org/10.1016/j.jalz.2010.12.003

The change in the world's age demographics and the predicted rise in the incidence of age-related diseases, including dementia, is a source of major public health concern. Major research effort in both the United States and Europe has been targeted t... Read More about A European perspective on population studies of dementia.

Objective measures of physical capability and subsequent health: A systematic review (2011)
Journal Article
Cooper, R., Kuh, D., Cooper, C., Gale, C. R., Lawlor, D. A., Matthews, F., & Hardy, R. (2011). Objective measures of physical capability and subsequent health: A systematic review. Age and ageing, 40(1), 14-23. https://doi.org/10.1093/ageing/afq117

Background: measures of physical capability may be predictive of subsequent health, but existing published studies have not been systematically reviewed. We hypothesised that weaker grip strength, slower walking speed and chair rising and shorter sta... Read More about Objective measures of physical capability and subsequent health: A systematic review.

Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain (2010)
Journal Article
Simpson, J. E., Wharton, S. B., Cooper, J., Gelsthorpe, C., Baxter, L., Forster, G., Shaw, P. J., Savva, G., Matthews, F. E., Brayne, C., & Ince, P. G. (2010). Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain. Neuroscience letters, 486(3), 246-251. https://doi.org/10.1016/j.neulet.2010.09.063

White matter lesions (WML) are associated with dementia and are common in brain ageing. In order to determine whether alteration of the blood-brain barrier (BBB) may contribute to the pathogenesis of WML we assessed albumin leakage and expression of... Read More about Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain.

Behavioural and psychological symptoms in the older population without dementia - Relationship with socio-demographics, health and cognition (2010)
Journal Article
Van Der Linde, R., Stephan, B. C., Matthews, F. E., Brayne, C., & Savva, G. M. (2010). Behavioural and psychological symptoms in the older population without dementia - Relationship with socio-demographics, health and cognition. BMC Geriatrics, 10, https://doi.org/10.1186/1471-2318-10-87

Background: Behavioural and psychological symptoms are associated with dementia, but are also present in a significant number of the older population without dementia. Here we explore the distribution of behavioural and psychological symptoms in the... Read More about Behavioural and psychological symptoms in the older population without dementia - Relationship with socio-demographics, health and cognition.

Design for independent living: Activity demands and capabilities of older people (2010)
Journal Article
Seidel, D., Richardson, K., Crilly, N., Matthews, F. E., Clarkson, P. J., & Brayne, C. (2010). Design for independent living: Activity demands and capabilities of older people. Ageing and Society, 30(7), 1239-1255. https://doi.org/10.1017/S0144686X10000310

The ability to perform the instrumental activities of daily living (IADLs) is an important focus for the promotion of independent living in old age. If strategies to enable older people to remain in their own homes are to be developed, advances must... Read More about Design for independent living: Activity demands and capabilities of older people.

Are optimal levels of testosterone associated with better cognitive function in healthy older women and men? (2010)
Journal Article
Hogervorst, E., Matthews, F. E., & Brayne, C. (2010). Are optimal levels of testosterone associated with better cognitive function in healthy older women and men?. BBA - General Subjects, 1800(10), 1145-1152. https://doi.org/10.1016/j.bbagen.2009.12.009

Background: Sex steroids can positively affect the brain and from this it would follow that high levels of sex steroids could be associated with better cognitive function in older men and women. Methods: This Healthy Ageing Study sample comprised of... Read More about Are optimal levels of testosterone associated with better cognitive function in healthy older women and men?.

Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people (2010)
Journal Article
Cluett, C., Brayne, C., Clarke, R., Evans, G., Matthews, F., Rubinsztein, D. C., Huppert, F., Llewellyn, D. J., Rice, N., Henley, W., Frayling, T. M., Murray, A., & Melzer, D. (2010). Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people. Neurobiology of Aging, 31(9), 1563-1568. https://doi.org/10.1016/j.neurobiolaging.2008.08.020

A recent genome-wide association (GWA) study of late-onset Alzheimer's disease (LOAD) identified 15 novel single nucleotide polymorphisms (SNPs) independent of ApoE. We hypothesised that variants associated with LOAD are also associated with poor cog... Read More about Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people.

Vascular health, diabetes, APOE and dementia: The aging, demographics, and memory study (2010)
Journal Article
Llewellyn, D. J., Lang, I. A., Matthews, F. E., Plassman, B. L., Rogers, M. A., Morgenstern, L. B., Fisher, G. G., Kabeto, M. U., & Langa, K. M. (2010). Vascular health, diabetes, APOE and dementia: The aging, demographics, and memory study. Alzheimer's Research and Therapy, 2(3), https://doi.org/10.1186/alzrt43

Introduction. Evidence from clinical samples and geographically limited population studies suggests that vascular health, diabetes and apolipoprotein 4 (APOE) are associated with dementia. Methods. A population-based sample of 856 individuals aged 71... Read More about Vascular health, diabetes, APOE and dementia: The aging, demographics, and memory study.

Who will be eligible? An investigation of the dementia population eligible for cholinesterase treatment following the change in NICE guidance (2010)
Journal Article
Matthews, F. E., Muniz-Terrera, G., McKeith, I., & Brayne, C. (2010). Who will be eligible? An investigation of the dementia population eligible for cholinesterase treatment following the change in NICE guidance. International journal of geriatric psychiatry, 25(7), 719-724. https://doi.org/10.1002/gps.2413

Objectives: Investigate the impact of the changes in eligibility within England and Wales (E&W) for prescription within the UK National Health Service for treatment of Alzheimer's disease (AD). Methods: A population-based study in England and Wales w... Read More about Who will be eligible? An investigation of the dementia population eligible for cholinesterase treatment following the change in NICE guidance.

Dementia risk prediction in the population: Are screening models accurate? (2010)
Journal Article
Stephan, B. C., Kurth, T., Matthews, F. E., Brayne, C., & Dufouil, C. (2010). Dementia risk prediction in the population: Are screening models accurate?. Nature Reviews Neurology, 6(6), 318-326. https://doi.org/10.1038/nrneurol.2010.54

Early identification of individuals at risk of dementia will become crucial when effective preventative strategies for this condition are developed. Various dementia prediction models have been proposed, including clinic-based criteria for mild cogni... Read More about Dementia risk prediction in the population: Are screening models accurate?.

Estimating stroke-free and total life expectancy in the presence of non-ignorable missing values (2010)
Journal Article
van den Hout, A., & Matthews, F. E. (2010). Estimating stroke-free and total life expectancy in the presence of non-ignorable missing values. Journal of the Royal Statistical Society. Series A, (Statistics in society), 173(2), 331-349. https://doi.org/10.1111/j.1467-985X.2009.00610.x

A continuous time three-state model with time-dependent transition intensities is formulated to describe transitions between healthy and unhealthy states before death. By using time continuously, known death times can be taken into account. To deal w... Read More about Estimating stroke-free and total life expectancy in the presence of non-ignorable missing values.

Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain (2010)
Journal Article
Simpson, J. E., Ince, P. G., Lace, G., Forster, G., Shaw, P. J., Matthews, F., Savva, G., Brayne, C., & Wharton, S. B. (2010). Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain. Neurobiology of Aging, 31(4), 578-590. https://doi.org/10.1016/j.neurobiolaging.2008.05.015

Astrocyte pathology occurs in association with Alzheimer's disease (AD) and in brain ageing, but is poorly characterised. We sought to define the detailed cellular pathology of astrocytes, the extent of population variation and the relationship to Al... Read More about Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain.

One size fits all? Why we need more sophisticated analytical methods in the explanation of trajectories of cognition in older age and their potential risk factors (2010)
Journal Article
Terrera, G. M., Brayne, C., & Matthews, F. (2010). One size fits all? Why we need more sophisticated analytical methods in the explanation of trajectories of cognition in older age and their potential risk factors. International Psychogeriatrics, 22(2), 291-299. https://doi.org/10.1017/S1041610209990937

Background: Cognitive decline in old age varies among individuals. The identification of groups of individuals with similar patterns of cognitive change over time may improve our ability to see whether the effect of risk factors is consistent across... Read More about One size fits all? Why we need more sophisticated analytical methods in the explanation of trajectories of cognition in older age and their potential risk factors.

Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain (2010)
Journal Article
Simpson, J. E., Ince, P. G., Haynes, L. J., Theaker, R., Gelsthorpe, C., Baxter, L., Forster, G., Lace, G. L., Shaw, P. J., Matthews, F. E., Savva, G. M., Brayne, C., & Wharton, S. B. (2010). Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain. Neuropathology and Applied Neurobiology, 36(1), 25-40. https://doi.org/10.1111/j.1365-2990.2009.01030.x

Aims: Increasing evidence suggests a role for oxidative damage to DNA in brain ageing and in neurodegenerative disorders, including Alzheimer's disease. Most studies have focussed on the reduced capacity for DNA repair by neurones, and have not taken... Read More about Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer-type pathology in the ageing brain.

Education, the brain and dementia: Neuroprotection or compensation? (2010)
Journal Article
Brayne, C., Ince, P. G., Keage, H. A., McKeith, I. G., Matthews, F. E., Polvikoski, T., & Sulkava, R. (2010). Education, the brain and dementia: Neuroprotection or compensation?. Brain, 133(8), 2210-2216. https://doi.org/10.1093/brain/awq185

The potential protective role of education for dementia is an area of major interest. Almost all older people have some pathology in their brain at death but have not necessarily died with dementia. We have explored these two observations in large po... Read More about Education, the brain and dementia: Neuroprotection or compensation?.