All Outputs (4)

Investigating the impact of α-synuclein and PD-L1 deletion on platelet function (2025)
Thesis
Sennett, C. (2025). Investigating the impact of α-synuclein and PD-L1 deletion on platelet function. (Thesis). University of Hull and University of York. https://hull-repository.worktribe.com/output/5182732

Platelet proteomic studies suggest that platelets express over 1,000 proteins, most of which have no known function in platelets. This thesis investigates two such proteins, α-synuclein and Programmed Death Ligand 1 (PD-L1), and their roles in essent... Read More about Investigating the impact of α-synuclein and PD-L1 deletion on platelet function.

An investigation into the TRPV1-CGRP signalling pathway in vessel development (2024)
Thesis
Bates, A. An investigation into the TRPV1-CGRP signalling pathway in vessel development. (Thesis). University of Hull. https://hull-repository.worktribe.com/output/4865918

TRPV1 is a non-selective cation channel which is activated through various different factors including, but not limited to, raised temperature and acidic pH. It has been linked in the past to endothelial cell proliferation in acidic conditions, but a... Read More about An investigation into the TRPV1-CGRP signalling pathway in vessel development.

RHOBTB GTPase cycle (2020)
Data
Orlic-Milacic, M. RHOBTB GTPase cycle. [Data]. https://doi.org/10.3180/r-hsa-9706574.1

RHO BTB family belongs to atypical RHO GTPases, which are characterized by the absence of GTPase activity. RhoBTB family includes RHOBTB1 and RHOBTB2. RHOBTB3 is sometimes classified as the third RhoBTB family member, but it is divergent from the oth... Read More about RHOBTB GTPase cycle.

An attenuating role of a WASP-related protein, WASP-B, in the regulation of F-actin polymerization and pseudopod formation via the regulation of RacC during Dictyostelium chemotaxis (2013)
Journal Article
Chung, C. Y., Feoktistov, A., Hollingsworth, R. J., Rivero, F., & Mandel, N. S. (2013). An attenuating role of a WASP-related protein, WASP-B, in the regulation of F-actin polymerization and pseudopod formation via the regulation of RacC during Dictyostelium chemotaxis. Biochemical and biophysical research communications, 436(4), 719-724. https://doi.org/10.1016/j.bbrc.2013.06.022

The WASP family of proteins has emerged as important regulators that connect multiple signaling pathways to regulate the actin cytoskeleton. Dictyostelium cells express WASP, as well as a WASP related protein, WASP-B, endoded by wasB gene. WASP-B con... Read More about An attenuating role of a WASP-related protein, WASP-B, in the regulation of F-actin polymerization and pseudopod formation via the regulation of RacC during Dictyostelium chemotaxis.