RHOBTB GTPase cycle

Orlic-Milacic, Marija

Abstract

RHO BTB family belongs to atypical RHO GTPases, which are characterized by the absence of GTPase activity. RhoBTB family includes RHOBTB1 and RHOBTB2. RHOBTB3 is sometimes classified as the third RhoBTB family member, but it is divergent from the other two RHOBTBs and from Rho GTPases in general. RHOBTB1 is a component of a signaling cascade that regulates vascular function and blood pressure (Ji and Rivero 2016). RHOBTB2 is involved in COP9 signalosome-regulated and CUL3-dependent protein ubiquitination (Berthold et al. 2008; Ji and Rivero 2016).

Citation

Orlic-Milacic, M. RHOBTB GTPase cycle. [Data]. https://doi.org/10.3180/r-hsa-9706574.1

• Online Publication Date: Nov 7, 2020
• Deposit Date: Oct 23, 2024
• DOI: https://doi.org/10.3180/r-hsa-9706574.1
• Public URL: https://hull-repository.worktribe.com/output/3674308
• Publisher URL: https://reactome.org/content/detail/R-HSA-9706574.1
• Collection Date: Oct 13, 2020