All Outputs (16)

Genomic analysis of companion rabbit Staphylococcus aureus (2016)
Journal Article
Holmes, M. A., Harrison, E. M., Fisher, E. A., Graham, E. M., Parkhill, J., Foster, G., & Paterson, G. K. (2016). Genomic analysis of companion rabbit Staphylococcus aureus. PLoS ONE, 11(3), e0151458. https://doi.org/10.1371/journal.pone.0151458

© 2016 Holmes et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are cre... Read More about Genomic analysis of companion rabbit Staphylococcus aureus.

The effect of genetic structure on molecular dating and tests for temporal signal (2015)
Journal Article
Murray, G. G., Wang, F., Harrison, E. M., Paterson, G. K., Mather, A. E., Harris, S. R., Holmes, M. A., Rambaut, A., & Welch, J. J. (2016). The effect of genetic structure on molecular dating and tests for temporal signal. Methods in ecology and evolution British Ecological Society, 7(1), 80-89. https://doi.org/10.1111/2041-210x.12466

© 2016 British Ecological Society. 'Dated-tip' methods of molecular dating use DNA sequences sampled at different times, to estimate the age of their most recent common ancestor. Several tests of 'temporal signal' are available to determine whether d... Read More about The effect of genetic structure on molecular dating and tests for temporal signal.

Old drugs to treat resistant bugs: Methicillin-resistant Staphylococcus aureus isolates with mecC are susceptible to a combination of penicillin and clavulanic acid (2015)
Journal Article
Ba, X., Harrison, E. M., Lovering, A. L., Gleadall, N., Zadoks, R., Parkhill, J., Peacock, S. J., Holden, M. T. G., Paterson, G. K., & Holmes, M. A. (2015). Old drugs to treat resistant bugs: Methicillin-resistant Staphylococcus aureus isolates with mecC are susceptible to a combination of penicillin and clavulanic acid. Antimicrobial agents and chemotherapy, 59(12), 7396-7404. https://doi.org/10.1128/AAC.01469-15

β-Lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) is mediated by the expression of an alternative penicillin-binding protein 2a (PBP2a) (encoded by mecA) with a low affinity for β-lactam antibiotics. Recently, a novel variant... Read More about Old drugs to treat resistant bugs: Methicillin-resistant Staphylococcus aureus isolates with mecC are susceptible to a combination of penicillin and clavulanic acid.

Draft genome sequence of the Streptococcus pneumoniae Avery strain A66 (2015)
Journal Article
Hahn, C., Harrison, E. M., Parkhill, J., Holmes, M. A., & Paterson, G. K. (2018). Draft genome sequence of the Streptococcus pneumoniae Avery strain A66. Genome announcements, 3(3), Article e00697-15. https://doi.org/10.1128/genomeA.00697-15

We have used HiSeq 2000 technology to generate a draft genome sequence of Streptococcus pneumoniae strain A66. This is a common study strain used in investigations of pneumococcal bacterium-host interactions and was used in the seminal genetic studie... Read More about Draft genome sequence of the Streptococcus pneumoniae Avery strain A66.

Detection of livestock-associated meticillin-resistant Staphylococcus aureus CC398 in retail pork, United Kingdom, February 2015 (2015)
Journal Article
Hadjirin, N., Lay, E., Paterson, G., Harrison, E., Peacock, S., Parkhill, J., Zadoks, R., & Holmes, M. (2015). Detection of livestock-associated meticillin-resistant Staphylococcus aureus CC398 in retail pork, United Kingdom, February 2015. Euro surveillance bulletin européen sur les maladies transmissibles = European communicable disease bulletin, 20(24), 21156. https://doi.org/10.2807/1560-7917.es2015.20.24.21156

Livestock-associated meticillin-resistant Staphylococcus aureus belonging to clonal complex 398 (LA-MRSA CC398) is an important cause of zoonotic infections in many countries. Here, we describe the isolation of LA-MRSA CC398 from retail meat samples... Read More about Detection of livestock-associated meticillin-resistant Staphylococcus aureus CC398 in retail pork, United Kingdom, February 2015.

Mechanisms of methicillin resistance in Staphylococcus aureus (2015)
Journal Article
Peacock, S. J., & Paterson, G. K. (2015). Mechanisms of methicillin resistance in Staphylococcus aureus. Annual review of biochemistry, 84(1), 577-601. https://doi.org/10.1146/annurev-biochem-060614-034516

Staphylococcus aureus is a major human and veterinary pathogen worldwide. Methicillin-resistant S. aureus (MRSA) poses a significant and enduring problem to the treatment of infection by such strains. Resistance is usually conferred by the acquisitio... Read More about Mechanisms of methicillin resistance in Staphylococcus aureus.

Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission (2015)
Journal Article
Paterson, G. K., Harrison, E. M., Murray, G. G. R., Welch, J. J., Warland, J. H., Holden, M. T. G., Morgan, F. J. E., Ba, X., Koop, G., Harris, S. R., Maskell, D. J., Peacock, S. J., Herrtage, M. E., Parkhill, J., & Holmes, M. A. (2015). Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission. Nature communications, 6(1), https://doi.org/10.1038/ncomms7560

Genome sequencing is revolutionizing clinical microbiology and our understanding of infectious diseases. Previous studies have largely relied on the sequencing of a single isolate from each individual. However, it is not clear what degree of bacteria... Read More about Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission.

Detection of mecC-Methicillin-resistant Staphylococcus aureus isolates in river water : a potential role for water in the environmental dissemination (2014)
Journal Article
Porrero, M. C., Harrison, E. M., Fernández-Garayzábal, J. F., Paterson, G. K., Díez-Guerrier, A., Holmes, M. A., & Domínguez Rodríguez, L. (2014). Detection of mecC-Methicillin-resistant Staphylococcus aureus isolates in river water : a potential role for water in the environmental dissemination. Environmental microbiology reports, 6(6), 705-708. https://doi.org/10.1111/1758-2229.12191

Methicillin-resistant Staphylococcus aureus (MRSA) is a public health concern due to limited treatment options. The recent description of a mecA homologue, mecC in human and cattle, led to studies to detect this new variant in human and other animal... Read More about Detection of mecC-Methicillin-resistant Staphylococcus aureus isolates in river water : a potential role for water in the environmental dissemination.

Short communication: Biofilm production characterization of mecA and mecC methicillin-resistant Staphylococcus aureus isolated from bovine milk in Great Britain (2014)
Journal Article
Prenafeta, A., Sitjà, M., Holmes, M. A., & Paterson, G. K. (2014). Short communication: Biofilm production characterization of mecA and mecC methicillin-resistant Staphylococcus aureus isolated from bovine milk in Great Britain. Journal of dairy science, 97(8), 4838-4841. https://doi.org/10.3168/jds.2014-7986

Staphylococcus aureus is an important cause of contagious intramammary infection in dairy cattle and the ability to produce biofilm is considered to be an important virulence property in the pathogenesis of mastitis. The aim of this study was to char... Read More about Short communication: Biofilm production characterization of mecA and mecC methicillin-resistant Staphylococcus aureus isolated from bovine milk in Great Britain.

A shared population of epidemic methicillin-resistant staphylococcus aureus 15 circulates in humans and companion animals (2014)
Journal Article
Harrison, E. M., Weinert, L. A., Holden, M. T. G., Welch, J. J., Wilson, K., Morgan, F. J. E., Harris, S. R., Loeffler, A., Boag, A. K., Peacock, S. J., Paterson, G. K., Waller, A. S., Parkhill, J., & Holmes, M. A. (2014). A shared population of epidemic methicillin-resistant staphylococcus aureus 15 circulates in humans and companion animals. mBio, 5(3), Article ARTN e00985-13. https://doi.org/10.1128/mBio.00985-13

Methicillin-resistant Staphylococcus aureus (MRSA) is a global human health problem causing infections in both hospitals and the community. Companion animals, such as cats, dogs, and horses, are also frequently colonized by MRSA and can become infect... Read More about A shared population of epidemic methicillin-resistant staphylococcus aureus 15 circulates in humans and companion animals.

Conjugative transfer frequencies of mef(A)-containing Tn1207.3 to macrolide-susceptible Streptococcus pyogenes belonging to different emm types (2014)
Journal Article
Hadjirin, N. F., Harrison, E. M., Holmes, M. A., & Paterson, G. K. (2014). Conjugative transfer frequencies of mef(A)-containing Tn1207.3 to macrolide-susceptible Streptococcus pyogenes belonging to different emm types. Letters in applied microbiology, 58(4), 299-302. https://doi.org/10.1111/lam.12213

The aim of this study was to examine the gene transfer potential of mef(A)-containing Tn120.3 to macrolide-susceptible Streptococcus pyogenes belonging to different emm types. Using the filter mating technique, Tn1207.3 was transferred by conjugation... Read More about Conjugative transfer frequencies of mef(A)-containing Tn1207.3 to macrolide-susceptible Streptococcus pyogenes belonging to different emm types.

The emergence of mecC methicillin-resistant Staphylococcus aureus (2013)
Journal Article
Paterson, G. K., Harrison, E. M., & Holmes, M. A. (2014). The emergence of mecC methicillin-resistant Staphylococcus aureus. Trends in microbiology, 22(1), 42-47. https://doi.org/10.1016/j.tim.2013.11.003

The report of methicillin-resistant Staphylococcus aureus (MRSA) encoding a divergent mecA gene in 2011 was highly significant. This homologue, designated mecC, poses diagnostic problems with the potential to be misdiagnosed as methicillin-sensitive... Read More about The emergence of mecC methicillin-resistant Staphylococcus aureus.

A novel hybrid SCCmec-mecC region in Staphylococcus sciuri (2013)
Journal Article
Harrison, E. M., Paterson, G. K., Holden, M. T. G., Ba, X., Rolo, J., Morgan, F. J. E., Pichon, B., Kearns, A., Zadoks, R. N., Peacock, S. J., Parkhill, J., & Holmes, M. A. (2014). A novel hybrid SCCmec-mecC region in Staphylococcus sciuri. The journal of antimicrobial chemotherapy, 69(4), 911-918. https://doi.org/10.1093/jac/dkt452

Objectives Methicillin resistance in Staphylococcus spp. results from the expression of an alternative penicillin-binding protein 2a (encoded by mecA) with a low affinity for β-lactam antibiotics. Recently, a novel variant of mecA known as mecC (form... Read More about A novel hybrid SCCmec-mecC region in Staphylococcus sciuri.

Prevalence and characterization of human mecC methicillin-resistant Staphylococcus aureus isolates in England (2013)
Journal Article
Paterson, G. K., Morgan, F. J. E., Harrison, E. M., Cartwright, E. J. P., Török, M. E., Zadoks, R. N., Parkhill, J., Peacock, S. J., & Holmes, M. A. (2014). Prevalence and characterization of human mecC methicillin-resistant Staphylococcus aureus isolates in England. The journal of antimicrobial chemotherapy, 69(4), 907-910. https://doi.org/10.1093/jac/dkt462

Objectives There are limited data available on the epidemiology and prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in the human population that encode the recently described mecA homologue, mecC. To address this knowledge gap we und... Read More about Prevalence and characterization of human mecC methicillin-resistant Staphylococcus aureus isolates in England.

Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec gene (2013)
Journal Article
Ba, X., Harrison, E. M., Edwards, G. F., Holden, M. T., Larsen, A. R., Petersen, A., Skov, R. L., Peacock, S. J., Parkhill, J., Paterson, G. K., & Holmes, M. A. (2014). Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec gene. The journal of antimicrobial chemotherapy, 69(3), 594-597. https://doi.org/10.1093/jac/dkt418

Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) is an important global health problem. MRSA resistance to β-lactam antibiotics is mediated by the mecA or mecC genes, which encode an alternative penicillin binding protein (PBP)2a that h... Read More about Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec gene.

Prevalence and properties of mecC methicillin-resistant Staphylococcus aureus (MRSA) in bovine bulk tank milk in Great Britain (2013)
Journal Article
Paterson, G. K., Morgan, F. J. E., Harrison, E. M., Peacock, S. J., Parkhill, J., Zadoks, R. N., & Holmes, M. A. (2014). Prevalence and properties of mecC methicillin-resistant Staphylococcus aureus (MRSA) in bovine bulk tank milk in Great Britain. The journal of antimicrobial chemotherapy, 69(3), 598-602. https://doi.org/10.1093/jac/dkt417

Objectives mecC methicillin-resistant Staphylococcus aureus (MRSA) represent a newly recognized form of MRSA, distinguished by the possession of a divergent mecA homologue, mecC. The first isolate to be identified came from bovine milk, but there are... Read More about Prevalence and properties of mecC methicillin-resistant Staphylococcus aureus (MRSA) in bovine bulk tank milk in Great Britain.