All Outputs (17)

Do T2DM and Hyperglycaemia Affect the Expression Levels of the Regulating Enzymes of Cellular O-GlcNAcylation in Human Saphenous Vein Smooth Muscle Cells? (2024)
Journal Article
Bolanle, I. O., Durham, G., Hobkirk, J. P., Loubani, M., Sturmey, R. G., & Palmer, T. M. (2024). Do T2DM and Hyperglycaemia Affect the Expression Levels of the Regulating Enzymes of Cellular O-GlcNAcylation in Human Saphenous Vein Smooth Muscle Cells?. Diabetology, 5(2), 162-177. https://doi.org/10.3390/diabetology5020013

Protein O-GlcNAcylation, a dynamic and reversible glucose-dependent post-translational modification of serine and threonine residues on target proteins, has been proposed to promote vascular smooth muscle cell proliferation and migration events impli... Read More about Do T2DM and Hyperglycaemia Affect the Expression Levels of the Regulating Enzymes of Cellular O-GlcNAcylation in Human Saphenous Vein Smooth Muscle Cells?.

Metabolic risk is associated with sociodemographic characteristics in adolescents from both rural and urban regions from southern Brazil (2022)
Journal Article
de Souza, S., Francisco de Castro Silveira, J., Marques, K. C., Gaya, A. R., Franke, S. I. R., Renner, J. D. P., …Reuter, C. P. (2022). Metabolic risk is associated with sociodemographic characteristics in adolescents from both rural and urban regions from southern Brazil. BMC Pediatrics, 22(1), Article 324. https://doi.org/10.1186/s12887-022-03386-z

Background: The prevalence of several cardiovascular metabolic disorders are increasingly cause for concern in adolescents worldwide. Given the complex interrelations between metabolic risk (MR) and sociodemographic variables, the present study aims... Read More about Metabolic risk is associated with sociodemographic characteristics in adolescents from both rural and urban regions from southern Brazil.

Anthropometric and Metabolic Responses in FTO rs9939609 Gene Polymorphism after a Multidisciplinary Lifestyle Intervention in Overweight and Obese Adolescents (2019)
Journal Article
Barbian, C. D., Reuter, C. P., Renner, J. D. P., da Silva, P. T., Klinger, E. I., Hobkirk, J. P., de Moura Valim, A. R., & Burgos, M. S. (2020). Anthropometric and Metabolic Responses in FTO rs9939609 Gene Polymorphism after a Multidisciplinary Lifestyle Intervention in Overweight and Obese Adolescents. Journal of Pediatric Genetics, 9(1), 019-026. https://doi.org/10.1055/s-0039-3399511

Few studies show the potential changing effect of fat-mass and obesity-associated (FTO) rs9939609 gene on cardiometabolic risk after a lifestyle intervention. This study aims to evaluate whether overweight and obese adolescents, carriers of the risk... Read More about Anthropometric and Metabolic Responses in FTO rs9939609 Gene Polymorphism after a Multidisciplinary Lifestyle Intervention in Overweight and Obese Adolescents.

The effect of atorvastatin (and subsequent metformin) on adipose tissue acylation-stimulatory-protein concentration and inflammatory biomarkers in overweight/obese women with polycystic ovary syndrome (2019)
Journal Article
Sathyapalan, T., Hobkirk, J. P., Javed, Z., Carroll, S., Coady, A. M., Pemberton, P., Smith, A., Cianflone, K., & Atkin, S. L. (2019). The effect of atorvastatin (and subsequent metformin) on adipose tissue acylation-stimulatory-protein concentration and inflammatory biomarkers in overweight/obese women with polycystic ovary syndrome. Frontiers in endocrinology, 10(JUN), Article 394. https://doi.org/10.3389/fendo.2019.00394

Copyright © 2019 Sathyapalan, Hobkirk, Javed, Carroll, Coady, Pemberton, Smith, Cianflone and Atkin. Background: Atorvastatin has been shown to improve cardiovascular risk (CVR) indices in women with polycystic ovary syndrome (PCOS). Low-grade chroni... Read More about The effect of atorvastatin (and subsequent metformin) on adipose tissue acylation-stimulatory-protein concentration and inflammatory biomarkers in overweight/obese women with polycystic ovary syndrome.

Myocardial energy metabolism in patients undergoing cardiac surgery (2018)
Thesis
Haqzad, Y. S. (2018). Myocardial energy metabolism in patients undergoing cardiac surgery. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4221969

In chapter 1, short and long term outcomes were assessed in diabetic phenotypes. The phenotypes have been propensity matched for factors that significantly contribute to outcomes. Tablet controlled diabetics have worse short and long term outcomes co... Read More about Myocardial energy metabolism in patients undergoing cardiac surgery.

Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR–/–and LDLR+/+mice (2017)
Journal Article
Carroll, S., Hobkirk, J., Browning, M. J., Janus, J., Kheder, R., Saeed, Z., & Stover, C. (2017). Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR–/–and LDLR+/+mice. Immunity, Inflammation and Disease, 5(2), 151-154. https://doi.org/10.1002/iid3.154

© 2017 The Authors. Immunity, Inflammation and Disease Published by John Wiley & Sons Ltd. INTRODUCTION: Fatty liver disease is prevalent in populations with high caloric intake. Nutritherapeutic approaches are being considered, such as supplementa... Read More about Vitamin D3 supplementation of a high fat high sugar diet ameliorates prediabetic phenotype in female LDLR–/–and LDLR+/+mice.

In vitro modulation of the LPS-induced proinflammatory profile of hepatocytes and macrophages-approaches for intervention in obesity? (2016)
Journal Article
Kheder, R. K., Hobkirk, J., & Stover, C. M. (2016). In vitro modulation of the LPS-induced proinflammatory profile of hepatocytes and macrophages-approaches for intervention in obesity?. Frontiers in Cell and Developmental Biology, 4(JUN), Article 61. https://doi.org/10.3389/fcell.2016.00061

Low grade endotoxemia is a feature of obesity which is linked to development of steatohepatitis in non-alcoholic fatty liver disease. In this study, macrophages (J774) and hepatocytes (HepG2) were stimulated with lipopolysaccharide (LPS) from E. coli... Read More about In vitro modulation of the LPS-induced proinflammatory profile of hepatocytes and macrophages-approaches for intervention in obesity?.

The cardiorespiratory and vascular adaptations to a routine UK exercise based cardiac rehabilitation programme (2015)
Thesis
Nichols, S. J. (2015). The cardiorespiratory and vascular adaptations to a routine UK exercise based cardiac rehabilitation programme. (Thesis). University of Hull. Retrieved from https://hull-repository.worktribe.com/output/4218451

Introduction: Recent data suggests that UK cardiac rehabilitation (CR) programmes do not substantially improve cardiorespiratory fitness (CRF) or patient survival. The exercise dose prescribed as part of a routine CR programme may be insufficient. Th... Read More about The cardiorespiratory and vascular adaptations to a routine UK exercise based cardiac rehabilitation programme.

Exploring quality of life in patients with and without heart failure (2015)
Journal Article
Zhang, J., Hobkirk, J., Carroll, S., Pellicori, P., Clark, A. L., & Cleland, J. G. (2016). Exploring quality of life in patients with and without heart failure. International journal of cardiology, 202, 676-684. https://doi.org/10.1016/j.ijcard.2015.09.076

Aims The EuroHeart Failure Survey Questionnaire (EHFSQ-1) has 39 questions on symptoms and quality of life (QoL); many items are related. We sought to identify underlying clusters amongst EHFSQ-1 questions, construct an overall “QoL score” and invest... Read More about Exploring quality of life in patients with and without heart failure.

Development of a human model for the study of effects of hypoxia, exercise, and sildenafil on cardiac and vascular function in chronic heart failure (2015)
Journal Article
Damy, T., Hobkirk, J., Walters, M., Ciobanu, A., Rigby, A. S., Kallvikbacka-Bennett, A., Guellich, A., Dubois-Rande, J.-L., Hittinger, L., Clark, A. L., & Cleland, J. G. F. (2015). Development of a human model for the study of effects of hypoxia, exercise, and sildenafil on cardiac and vascular function in chronic heart failure. Journal of Cardiovascular Pharmacology, 66(3), 229-238. https://doi.org/10.1097/fjc.0000000000000262

Background: Pulmonary hypertension is associated with poor outcome in patients with chronic heart failure (CHF) and may be a therapeutic target. Our aims were to develop a noninvasive model for studying pulmonary vasoreactivity in CHF and characteriz... Read More about Development of a human model for the study of effects of hypoxia, exercise, and sildenafil on cardiac and vascular function in chronic heart failure.

On the functional overlap between complement and anti-microbial peptides (2015)
Journal Article
Stover, C. M., Hobkirk, J., Browning, M. J., Mohamed, F., & Zimmer, J. (2015). On the functional overlap between complement and anti-microbial peptides. Frontiers in immunology, 5(JAN), Article 689. https://doi.org/10.3389/fimmu.2014.00689

Intriguingly, activated complement and anti-microbial peptides share certain functionalities; lytic, phagocytic, and chemo-attractant activities and each may, in addition, exert cell instructive roles. Each has been shown to have distinct LPS detoxif... Read More about On the functional overlap between complement and anti-microbial peptides.

Effects of reducing inspired oxygen concentration for one hour in patients with chronic heart failure: implications for air travel (2013)
Journal Article
Hobkirk, J. P., Damy, T., Walters, M., Bennett, A., Smith, S. J., Ingle, L., Clark, A. L., & Cleland, J. G. (2013). Effects of reducing inspired oxygen concentration for one hour in patients with chronic heart failure: implications for air travel. European journal of heart failure, 15(5), 505-510. https://doi.org/10.1093/eurjhf/hft003

AimsThe objective of this study was to establish the acute effects of hypoxia on clinical, spirometric, haemodynamic, and echocardiographic variables. Reducing inspired oxygen to 15%, as experienced during commercial air travel, decreases arterial ox... Read More about Effects of reducing inspired oxygen concentration for one hour in patients with chronic heart failure: implications for air travel.

The metabolic inter-relationships between changes in waist circumference, triglycerides, insulin sensitivity and small, dense low-density lipoprotein particles with acute weight loss in clinically obese children and adolescents (2013)
Journal Article
Hobkirk, J. P., King, R. F., Davies, I., Harman, N., Gately, P., Pemberton, P., Smith, A., Barth, J. H., & Carroll, S. (2014). The metabolic inter-relationships between changes in waist circumference, triglycerides, insulin sensitivity and small, dense low-density lipoprotein particles with acute weight loss in clinically obese children and adolescents. Pediatric obesity : an official journal of the International Association for the Study of Obesity, 9(3), 209-217. https://doi.org/10.1111/j.2047-6310.2013.00165.x

Objective Small, dense low-density lipoprotein (LDL) particles are highly atherogenic and strongly associated with obesity-related dyslipidemia. The metabolic inter-relationships between weight loss induced changes in waist circumference, triglycerid... Read More about The metabolic inter-relationships between changes in waist circumference, triglycerides, insulin sensitivity and small, dense low-density lipoprotein particles with acute weight loss in clinically obese children and adolescents.

Prevalence of, associations with, and prognostic value of tricuspid annular plane systolic excursion (TAPSE) among out-patients referred for the evaluation of heart failure (2012)
Journal Article
Damy, T., Kallvikbacka-Bennett, A., Goode, K., Khaleva, O., Lewinter, C., Hobkirk, J., Nikitin, N. P., Dubois-Randé, J.-L., Hittinger, L., Clark, A. L., & Cleland, J. G. F. (2012). Prevalence of, associations with, and prognostic value of tricuspid annular plane systolic excursion (TAPSE) among out-patients referred for the evaluation of heart failure. Journal of cardiac failure, 18(3), 216-225. https://doi.org/10.1016/j.cardfail.2011.12.003

Background: Prevalence, predictors, and prognostic value of right ventricular (RV) function measured by the tricuspid annular plane systolic excursion (TAPSE) in patients with chronic heart failure (CHF) symptoms with a broad range of left ventricula... Read More about Prevalence of, associations with, and prognostic value of tricuspid annular plane systolic excursion (TAPSE) among out-patients referred for the evaluation of heart failure.

Does the physical examination still have a role in patients with suspected heart failure? (2011)
Journal Article
Damy, T., Kallvikbacka-Bennett, A., Zhang, J., Goode, K., Buga, L., Hobkirk, J., Yassin, A., Dubois-Randé, J.-L., Hittinger, L., Cleland, J. G. F., & Clark, A. L. (2011). Does the physical examination still have a role in patients with suspected heart failure?. European journal of heart failure, 13(12), 1340-1348. https://doi.org/10.1093/eurjhf/hfr128

AIMS: The prognostic value of signs of congestion in patients suspected of having chronic heart failure (CHF) is unknown. Our objectives were to define their prevalence and specificity in diagnosing CHF and to determine their prognostic value in pati... Read More about Does the physical examination still have a role in patients with suspected heart failure?.

Differential Improvements in Lipid Profiles and Framingham Recurrent Risk Score in Patients With and Without Diabetes Mellitus Undergoing Long-Term Cardiac Rehabilitation (2011)
Journal Article
Carroll, S., Tsakirides, C., Hobkirk, J., Moxon, J. W. D., Dudfield, M., & Ingle, L. (2011). Differential Improvements in Lipid Profiles and Framingham Recurrent Risk Score in Patients With and Without Diabetes Mellitus Undergoing Long-Term Cardiac Rehabilitation. Archives of physical medicine and rehabilitation, 92(9), 1382-1387. https://doi.org/10.1016/j.apmr.2011.04.013

OBJECTIVE: To determine whether lipid profiles and recurrent coronary heart disease (CHD) risk could be modified in patients with and without diabetes mellitus undergoing long-term cardiac rehabilitation (CR). DESIGN: Retrospective analysis of patien... Read More about Differential Improvements in Lipid Profiles and Framingham Recurrent Risk Score in Patients With and Without Diabetes Mellitus Undergoing Long-Term Cardiac Rehabilitation.

Experiences of air travel in patients with chronic heart failure (2011)
Journal Article
Ingle, L., Hobkirk, J., Damy, T., Nabb, S., Clark, A. L., & Cleland, J. G. (2012). Experiences of air travel in patients with chronic heart failure. International journal of cardiology, 158(1), 66-70. https://doi.org/10.1016/j.ijcard.2010.12.101

AIM: To conduct a survey in a representative cohort of ambulatory patients with stable, well managed chronic heart failure (CHF) to discover their experiences of air travel. METHODS: An expert panel including a cardiologist, an exercise scientist, an... Read More about Experiences of air travel in patients with chronic heart failure.