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A 18F radiolabelled Zn(ii) sensing fluorescent probe (2018)
Journal Article
Price, T. W., Firth, G., Eling, C. J., Kinnon, M., Long, N. J., Sturge, J., & Stasiuk, G. J. (2018). A 18F radiolabelled Zn(ii) sensing fluorescent probe. Chemical communications : Chem comm / the Royal Society of Chemistry, 54(26), 3227-3230. doi:10.1039/c8cc00687c

A selective fluorescent probe for Zn(ii), AQA-F, has been synthesized. AQA-F exhibits a ratiometric shift in emission of up to 80 nm upon binding Zn(ii) ([AQA-F] = 0.1 mM, [Zn(ii)Cl 2 ] = 0-300 μM). An enhancement of quantum yield from Φ = 4.2% to Φ... Read More

Endo180 at the cutting edge of bone cancer treatment and beyond (2016)
Journal Article
Sturge, J. (2016). Endo180 at the cutting edge of bone cancer treatment and beyond. Journal of Pathology, 238(4), (485-488). doi:10.1002/path.4673. ISSN 0022-3417

Skeletal bone is an attractive site for secondary tumour growth and is also home to spontaneous primary cancer. Treatment of bone metastasis is focused on limiting the vicious cycle of bone destruction with bisphosphonates or inhibition of receptor a... Read More

LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression (2014)
Journal Article
Hopkins, T. G., Mura, M., Abd-Latip, N., Aboagye, E., Mauri, F., Jameson, C., …Willis, A. (2015). LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression. Oncogene, 34(39), (5025-5036). doi:10.1038/onc.2014.428. ISSN 0950-9232

RNA-binding proteins (RBPs) bind to and post-transcriptionally regulate the stability of mRNAs. La-related protein 1 (LARP1) is a conserved RBP that interacts with poly-A-binding protein and is known to regulate 5′-terminal oligopyrimidine tract (TOP... Read More

Survival outcome and EMT suppression mediated by a lectin domain interaction of Endo180 and CD147 (2014)
Journal Article
Darby, S., Gaughan, L., Gronau, J. H., Mauri, F., Minamidate, A., Robson, C., …Waxman, J. (2015). Survival outcome and EMT suppression mediated by a lectin domain interaction of Endo180 and CD147. Molecular cancer research, 13(3), (538-547). doi:10.1158/1541-7786.mcr-14-0344-t. ISSN 1541-7786

Epithelial cell-cell contacts maintain normal glandular tissue homeostasis, and their breakage can trigger epithelial-to-mesenchymal transition (EMT), a fundamental step in the development of metastatic cancer. Despite the ability of C-type lectin do... Read More

Endo180 modulation by bisphosphonates and diagnostic accuracy in metastatic breast cancer (2012)
Journal Article
Caley, M. P., Woodley, L., Odendaal, J., Rodriguez-Teja, M., Kogianni, G., Purshouse, K., …Sturge, J. (2012). Endo180 modulation by bisphosphonates and diagnostic accuracy in metastatic breast cancer. The British journal of cancer / Cancer Research Campaign, 108(1), (163-169). doi:10.1038/bjc.2012.540. ISSN 0007-0920

Background:Endo180 (CD280; MRC2; uPARAP)-dependent collagen remodelling is dysregulated in primary tumours and bone metastasis. Here, we confirm the release and diagnostic accuracy of soluble Endo180 for diagnosing metastasis in breast cancer (BCa).M... Read More

Bone metastasis in prostate cancer: Emerging therapeutic strategies (2011)
Journal Article
Sturge, J., Caley, M. P., & Waxman, J. (2011). Bone metastasis in prostate cancer: Emerging therapeutic strategies. Nature Reviews Clinical Oncology, 8(6), (357-368). doi:10.1038/nrclinonc.2011.67. ISSN 1759-4774

Metastatic bone disease (MBD) in advanced-stage cancer increases the risk of intractable bone pain, pathological skeletal fracture, spinal-cord compression and decreased survival. The disease manifestation course during MBD is largely driven by homot... Read More

Biological and clinical implications of nicastrin expression in invasive breast cancer (2010)
Journal Article
Filipović, A., Gronau, J. H., Green, A. R., Wang, J., Vallath, S., Shao, D., …Sturge, J. (2011). Biological and clinical implications of nicastrin expression in invasive breast cancer. Breast cancer research and treatment, 125(1), (43-53). doi:10.1007/s10549-010-0823-1. ISSN 0167-6806

Nicastrin is an essential component of the gamma secretase (GS) enzyme complex, required for its synthesis and recognition of substrates for proteolytic cleavage. The purpose of this study was to investigate whether nicastrin has prognostic value or... Read More

Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate cancer progression (2008)
Journal Article
Sturge, J., Kogianni, G., Walker, M. M., & Waxman, J. (2009). Endo180 expression with cofunctional partners MT1-MMP and uPAR-uPA is correlated with prostate cancer progression. European Journal of Cancer, 45(4), 685-693. doi:10.1016/j.ejca.2008.11.023

Endo180 (CD280; MRC2; uPARAP) regulates collagen remodelling and chemotactic cell migration through cooperation with membrane type-1 matrix metalloproteinase (MT1-MMP), urokinase-type plasminogen activator receptor (uPAR) and urokinase-type plasminog... Read More