Thomas W. Price
A 18F radiolabelled Zn(ii) sensing fluorescent probe
Price, Thomas W.; Firth, George; Eling, Charlotte J.; Kinnon, Michelle; Long, Nicholas J.; Sturge, Justin; Stasiuk, Graeme J.
Authors
George Firth
Charlotte J. Eling
Michelle Kinnon
Nicholas J. Long
Justin Sturge
Graeme J. Stasiuk
Abstract
A selective fluorescent probe for Zn(ii), AQA-F, has been synthesized. AQA-F exhibits a ratiometric shift in emission of up to 80 nm upon binding Zn(ii) ([AQA-F] = 0.1 mM, [Zn(ii)Cl 2 ] = 0-300 μM). An enhancement of quantum yield from Φ = 4.2% to Φ = 35% is also observed. AQA-F has a binding constant, K d = 15.2 μM with Zn(ii). This probe has been shown to respond to endogenous Zn(ii) levels in vitro in prostate and prostate cancer cell lines. [ 18 F]AQA-F has been synthesized with a radiochemical yield of 8.6% and a radiochemical purity of 97% in 88 minutes. AQA-F shows the potential for a dual modal PET/fluorescence imaging probe for Zn(ii).
Citation
Price, T. W., Firth, G., Eling, C. J., Kinnon, M., Long, N. J., Sturge, J., & Stasiuk, G. J. (2018). A 18F radiolabelled Zn(ii) sensing fluorescent probe. Chemical communications : Chem comm / the Royal Society of Chemistry, 54(26), 3227-3230. https://doi.org/10.1039/c8cc00687c
Journal Article Type | Article |
---|---|
Acceptance Date | Mar 5, 2018 |
Online Publication Date | Mar 5, 2018 |
Publication Date | Mar 12, 2018 |
Deposit Date | Aug 2, 2018 |
Publicly Available Date | Mar 6, 2019 |
Journal | Chemical Communications |
Print ISSN | 1359-7345 |
Publisher | Royal Society of Chemistry |
Peer Reviewed | Peer Reviewed |
Volume | 54 |
Issue | 26 |
Pages | 3227-3230 |
DOI | https://doi.org/10.1039/c8cc00687c |
Public URL | https://hull-repository.worktribe.com/output/774341 |
Publisher URL | http://pubs.rsc.org/en/Content/ArticleLanding/2018/CC/C8CC00687C#!divAbstract |
Contract Date | Aug 3, 2018 |
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Copyright Statement
©2018 The authors
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