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A 18F radiolabelled Zn(ii) sensing fluorescent probe

Price, Thomas W.; Firth, George; Eling, Charlotte J.; Kinnon, Michelle; Long, Nicholas J.; Sturge, Justin; Stasiuk, Graeme J.


Thomas W. Price

George Firth

Charlotte J. Eling

Michelle Kinnon

Nicholas J. Long

Graeme J. Stasiuk


A selective fluorescent probe for Zn(ii), AQA-F, has been synthesized. AQA-F exhibits a ratiometric shift in emission of up to 80 nm upon binding Zn(ii) ([AQA-F] = 0.1 mM, [Zn(ii)Cl 2 ] = 0-300 μM). An enhancement of quantum yield from Φ = 4.2% to Φ = 35% is also observed. AQA-F has a binding constant, K d = 15.2 μM with Zn(ii). This probe has been shown to respond to endogenous Zn(ii) levels in vitro in prostate and prostate cancer cell lines. [ 18 F]AQA-F has been synthesized with a radiochemical yield of 8.6% and a radiochemical purity of 97% in 88 minutes. AQA-F shows the potential for a dual modal PET/fluorescence imaging probe for Zn(ii).


Price, T. W., Firth, G., Eling, C. J., Kinnon, M., Long, N. J., Sturge, J., & Stasiuk, G. J. (2018). A 18F radiolabelled Zn(ii) sensing fluorescent probe. Chemical communications : Chem comm / the Royal Society of Chemistry, 54(26), 3227-3230.

Journal Article Type Article
Acceptance Date Mar 5, 2018
Online Publication Date Mar 5, 2018
Publication Date Mar 12, 2018
Deposit Date Aug 2, 2018
Publicly Available Date Oct 27, 2022
Journal Chemical Communications
Print ISSN 1359-7345
Electronic ISSN 1364-548X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 54
Issue 26
Pages 3227-3230
Public URL
Publisher URL!divAbstract


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