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A 18F radiolabelled Zn(ii) sensing fluorescent probe

Price, Thomas W.; Firth, George; Eling, Charlotte J.; Kinnon, Michelle; Long, Nicholas J.; Sturge, Justin; Stasiuk, Graeme J.

Authors

Thomas W. Price

George Firth

Charlotte J. Eling

Michelle Kinnon

Nicholas J. Long

Abstract

A selective fluorescent probe for Zn(ii), AQA-F, has been synthesized. AQA-F exhibits a ratiometric shift in emission of up to 80 nm upon binding Zn(ii) ([AQA-F] = 0.1 mM, [Zn(ii)Cl 2 ] = 0-300 μM). An enhancement of quantum yield from Φ = 4.2% to Φ = 35% is also observed. AQA-F has a binding constant, K d = 15.2 μM with Zn(ii). This probe has been shown to respond to endogenous Zn(ii) levels in vitro in prostate and prostate cancer cell lines. [ 18 F]AQA-F has been synthesized with a radiochemical yield of 8.6% and a radiochemical purity of 97% in 88 minutes. AQA-F shows the potential for a dual modal PET/fluorescence imaging probe for Zn(ii).

Journal Article Type Article
Publication Date Mar 12, 2018
Journal Chemical Communications
Print ISSN 1359-7345
Electronic ISSN 1364-548X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 54
Issue 26
Pages 3227-3230
Institution Citation Price, T. W., Firth, G., Eling, C. J., Kinnon, M., Long, N. J., Sturge, J., & Stasiuk, G. J. (2018). A 18F radiolabelled Zn(ii) sensing fluorescent probe. Chemical communications : Chem comm / the Royal Society of Chemistry, 54(26), 3227-3230. https://doi.org/10.1039/c8cc00687c
DOI https://doi.org/10.1039/c8cc00687c
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2018/CC/C8CC00687C#!divAbstract
Copyright Statement ©2018 The authors

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