All Outputs (113)

Shared decision-making and deprescribing to support anti-thrombotic therapy (dis)continuance for persons living with cancer in their last phase of life: A realist synthesis (2025)
Journal Article
Jagosh, J., Pearson, M., Greenley, S., Maraveyas, A., Keser, G., Murtagh, F. E. M., Noble, S., Edwards, M., Edwards, A., Højen, A. A., Seddon, K., Klok, F. A., Mooijaart, S. P., Geijteman, E. C. T., & Johnson, M. J. (2025). Shared decision-making and deprescribing to support anti-thrombotic therapy (dis)continuance for persons living with cancer in their last phase of life: A realist synthesis. PLoS Medicine, 22(8), Article e1004663. https://doi.org/10.1371/journal.pmed.1004663

Introduction
Patients with cancer are at increased risk of thrombotic complications from both the disease and its treatments, with antithrombotic therapy (ATT) usually continued in the last phase of life where the benefit is less clear and there is... Read More about Shared decision-making and deprescribing to support anti-thrombotic therapy (dis)continuance for persons living with cancer in their last phase of life: A realist synthesis.

Developing a decision support tool for the continuation or deprescribing of antithrombotic therapy in patients receiving end-of-life care: Protocol for a European Delphi study". (2025)
Journal Article
Deneche, I., Couffignal, C., Si Mohammed, N., Arbjerg Højen, A., Font, C., Konstantinides, S., Kruip, M., Maiorana, L., Szmit, S., Abbel, D., Bertoletti, L., Edwards, A., Edwards, M., Gava, A., Gussekloo, J., Johnson, M. J., Kumar, R., Langendoen, J., Lifford, K., Mooijaart, S., …Mahé, I. (2025). Developing a decision support tool for the continuation or deprescribing of antithrombotic therapy in patients receiving end-of-life care: Protocol for a European Delphi study". Thrombosis Update, 19, Article 100209. https://doi.org/10.1016/j.tru.2025.100209

ABSTRACT
Introduction: To develop a European shared decision support tool (SDST), a Delphi process will be used to reach consensus about aspects relating to the continuation or deprescribing of antithrombotic therapy (ATT) in cancer patients at the... Read More about Developing a decision support tool for the continuation or deprescribing of antithrombotic therapy in patients receiving end-of-life care: Protocol for a European Delphi study"..

Developing a decision support tool for the continuation or deprescribing of antithrombotic therapy in patients receiving end-of-life care: Protocol for a European Delphi study (2025)
Journal Article
Deneche, I., Couffignal, C., Mohammed, N. S., Højen, A. A., Font, C., Konstantinides, S., Kruip, M., Maiorana, L., Szmit, S., Abbel, D., Bertoletti, L., Cannegieter, S., Edwards, A., Edwards, M., Gava, A., Gussekloo, J., Johnson, M. J., Kumar, R., Langendoen, J., Lifford, K., …Mahé, I. (2025). Developing a decision support tool for the continuation or deprescribing of antithrombotic therapy in patients receiving end-of-life care: Protocol for a European Delphi study. Thrombosis Research, 19, Article 100209. https://doi.org/10.1016/j.tru.2025.100209

Introduction: To develop a European shared decision support tool (SDST), a Delphi process will be used to reach consensus about aspects relating to the continuation or deprescribing of antithrombotic therapy (ATT) in cancer patients at the end of lif... Read More about Developing a decision support tool for the continuation or deprescribing of antithrombotic therapy in patients receiving end-of-life care: Protocol for a European Delphi study.

Support for hospital doctors' workplace well-being in England: The Care under Pressure 3 realist evaluation (2025)
Journal Article
Melvin, A., Pearson, A., Carrieri, D., Bramwell, C., Hancock, J., Scott, J., Foster Collins, H., McPhail, S., Pearson, M., Papoutsi, C., Wong, G., & Mattick, K. (2025). Support for hospital doctors' workplace well-being in England: The Care under Pressure 3 realist evaluation. BMJ Quality and Safety, https://doi.org/10.1136/bmjqs-2024-017698

Introduction: The vital role of medical workforce well-being for improving patient experience and population health while assuring safety and reducing costs is recognised internationally. Yet the persistence of poor well-being outcomes suggests that... Read More about Support for hospital doctors' workplace well-being in England: The Care under Pressure 3 realist evaluation.

Quality Standards of Transitional Programmes for International Medical Graduates: An International Modified Delphi Study to Develop a Theory-Based Framework (2025)
Journal Article
Murillo-Zepeda, C., Pearson, M., & Ellawala, A. (2025). Quality Standards of Transitional Programmes for International Medical Graduates: An International Modified Delphi Study to Develop a Theory-Based Framework. Clinical Teacher, 22(3), Article e70092. https://doi.org/10.1111/tct.70092

Background: Interventions aimed at supporting international medical graduates during the transition to host countries facilitate adjustment to these new workplace environments. Despite the progress made on clarifying the mechanisms operating behind s... Read More about Quality Standards of Transitional Programmes for International Medical Graduates: An International Modified Delphi Study to Develop a Theory-Based Framework.

BREATHLEssness in INDIA (BREATHE-INDIA): realist review to develop explanatory programme theory about breathlessness self-management in India (2025)
Journal Article
Clark, J., Salins, N., Sherigar, M., Williams, S., Pearson, M., Rao, S. R., Spathis, A., Bhat, R., Currow, D. C., Fraser, K., Simha, S., & Johnson, M. J. (2025). BREATHLEssness in INDIA (BREATHE-INDIA): realist review to develop explanatory programme theory about breathlessness self-management in India. NPJ Primary Care Respiratory Medicine, 35(1), Article 13. https://doi.org/10.1038/s41533-025-00420-2

Breathlessness is highly prevalent in low and middle-income countries (LMICs). Low-cost, non-drug, breathlessness self-management interventions are effective in high-income countries. However, health beliefs influence acceptability and have not been... Read More about BREATHLEssness in INDIA (BREATHE-INDIA): realist review to develop explanatory programme theory about breathlessness self-management in India.

ERS guideline recommendation on airflow for breathlessness: the pitfalls of applying GRADE evidence ratings to complex non-pharmacological interventions (2025)
Journal Article
Luckett, T., Swan, F., Clark, J., Roberts, M., Pearson, M., Hutchinson, A., Currow, D., Kochovska, S., Crooks, M., Smith, T., & Johnson, M. (2025). ERS guideline recommendation on airflow for breathlessness: the pitfalls of applying GRADE evidence ratings to complex non-pharmacological interventions. European respiratory journal, 65(2), Article 2402244. https://doi.org/10.1183/13993003.02244-2024

Antenatal pelvic floor muscle exercise intervention led by midwives in England to reduce postnatal urinary incontinence: APPEAL feasibility and pilot randomised controlled cluster trial (2025)
Journal Article
Macarthur, C., Bick, D., Salmon, V., Jones, E., Hay-Smith, J., Bishop, J., Gkini, E., Hemming, K., Webb, S., Pearson, M., Coleman, T., Terry, R., Edwards, E., Frawley, H., Oborn, E., & Dean, S. (2025). Antenatal pelvic floor muscle exercise intervention led by midwives in England to reduce postnatal urinary incontinence: APPEAL feasibility and pilot randomised controlled cluster trial. BMJ open, 15(1), Article e091248. https://doi.org/10.1136/bmjopen-2024-091248

Objectives To assess the feasibility of an intervention of midwifery support for antenatal pelvic floor muscle exercises (PFME) to prevent postnatal urinary incontinence (UI). Design Feasibility and pilot cluster randomised controlled trial. Clusters... Read More about Antenatal pelvic floor muscle exercise intervention led by midwives in England to reduce postnatal urinary incontinence: APPEAL feasibility and pilot randomised controlled cluster trial.

Correspondence on “Implementing palliative care in the intensive care unit: a systematic review and mapping of knowledge to the implementation research logic model” Authors’ reply (2025)
Journal Article
Meddick-Dyson, S. A., Pattison, N. A., Boland, J. W., Pearson, M., & Murtagh, F. E. (2025). Correspondence on “Implementing palliative care in the intensive care unit: a systematic review and mapping of knowledge to the implementation research logic model” Authors’ reply. Intensive care medicine, https://doi.org/10.1007/s00134-025-07849-6

Involving Patients and the Public in Cancer Associated Thrombosis Research: a strategy for success. (2024)
Journal Article
Edwards, M., Seddon, K., Baddeley, E., Ording, A. G., Pearson, M., Mahe, I., Mooijaart, S., Klok, F. A., Noble, S. I., & on behalf of the SERENITY consortium. (2025). Involving Patients and the Public in Cancer Associated Thrombosis Research: a strategy for success. Thrombosis journal, 18, Article 100196. https://doi.org/10.1016/j.tru.2024.100196

The role of public involvement (PI) in biomedical research has never been greater, with accumulating evidence demonstrating its ability to improve the quality of research and the likelihood of translating findings into clinical practice. As the deman... Read More about Involving Patients and the Public in Cancer Associated Thrombosis Research: a strategy for success..

Midwifery-led antenatal pelvic floor muscle exercise intervention to reduce postnatal urinary incontinence: APPEAL research programme including a feasibility and pilot cluster RCT (2024)
Journal Article
Macarthur, C., Bick, D., Salmon, V., Jones, E., Hay-Smith, J., Bishop, J., Gkini, E., Hemming, K., Webb, S., Pearson, M., Coleman, T., Terry, R., Edwards, L., Frawley, H., Oborn, E., & Dean, S. (2024). Midwifery-led antenatal pelvic floor muscle exercise intervention to reduce postnatal urinary incontinence: APPEAL research programme including a feasibility and pilot cluster RCT. Programme Grants for Applied Research, 12(9), https://doi.org/10.3310/TJDH7946

Background: Antenatal pelvic floor muscle exercises are effective in reducing postnatal urinary incontinence. Midwives, however, lack training and confidence to promote these exercises and often do not provide information or support to women to do th... Read More about Midwifery-led antenatal pelvic floor muscle exercise intervention to reduce postnatal urinary incontinence: APPEAL research programme including a feasibility and pilot cluster RCT.

Understanding European patterns of deprescribing antithrombotic medication during end-of-life care in patients with cancer (2024)
Journal Article
Martens, E. S., Becker, D., Abele, C., Abbel, D., Achterberg, W. P., Bax, J. J., Bertoletti, L., Edwards, M. E., Font, C., Gava, A., Goedegebuur, J., Højen, A. A., Huisman, M. V., Kruip, M. J., Mahé, I., Mooijaart, S. P., Pearson, M., Seddon, K., Szmit, S., Noble, S. I., …Konstantinides, S. V. (2025). Understanding European patterns of deprescribing antithrombotic medication during end-of-life care in patients with cancer. Thrombosis Research, 245, Article 109205. https://doi.org/10.1016/j.thromres.2024.109205

Background: Even though antithrombotic therapy (ATT) probably has little or even negative effect on the well-being of patients with cancer near the end of life, it is often continued until death, possibly leading to excess bleeding complications, inc... Read More about Understanding European patterns of deprescribing antithrombotic medication during end-of-life care in patients with cancer.

Implementing palliative care in the intensive care unit: a systematic review and mapping of knowledge to the implementation research logic model (2024)
Journal Article
Meddick‐Dyson, S. A., Boland, J. W., Pearson, M., Greenley, S., Gambe, R., Budding, J. R., & Murtagh, F. E. (online). Implementing palliative care in the intensive care unit: a systematic review and mapping of knowledge to the implementation research logic model. Intensive care medicine, https://doi.org/10.1007/s00134-024-07623-0

Purpose: The importance and effectiveness of palliative care (PC) in intensive care units (ICU) are known. Less is known about the implementation and integration of ICU-based PC interventions. This systematic review aims to use a modified implementat... Read More about Implementing palliative care in the intensive care unit: a systematic review and mapping of knowledge to the implementation research logic model.

Why do acute healthcare staff behave unprofessionally towards each other and how these behaviours can be reduced: A realist review (2024)
Journal Article
Aunger, J. A., Abrams, R., Westbrook, J., Wright, J., Pearson, M., Jones, A., Mannion, R., & Maben, J. (2024). Why do acute healthcare staff behave unprofessionally towards each other and how these behaviours can be reduced: A realist review. Health and Social Care Delivery Research, 25(12), https://doi.org/10.3310/PAMV3758

Background: Unprofessional behaviour in healthcare systems can negatively impact staff well-being, patient safety and organisational costs. Unprofessional behaviour encompasses a range of behaviours, including incivility, microaggressions, harassment... Read More about Why do acute healthcare staff behave unprofessionally towards each other and how these behaviours can be reduced: A realist review.

Why do acute healthcare staff behave unprofessionally towards each other and how can these behaviours be reduced? A realist review (2024)
Journal Article
Aunger, J. A., Abrams, R., Westbrook, J. I., Wright, J. M., Pearson, M., Jones, A., Mannion, R., & Maben, J. (2024). Why do acute healthcare staff behave unprofessionally towards each other and how can these behaviours be reduced? A realist review. Health and Social Care Delivery Research, 12(25), https://doi.org/10.3310/PAMV3758

Background: Unprofessional behaviour in healthcare systems can negatively impact staff well-being, patient safety and organisational costs. Unprofessional behaviour encompasses a range of behaviours, including incivility, microaggressions, harassment... Read More about Why do acute healthcare staff behave unprofessionally towards each other and how can these behaviours be reduced? A realist review.

How can interventions more directly address drivers of unprofessional behaviour between healthcare staff? (2024)
Journal Article
Aunger, J. A., Abrams, R., Mannion, R., Westbrook, J. I., Jones, A., Wright, J. M., Pearson, M., & Maben, J. (2024). How can interventions more directly address drivers of unprofessional behaviour between healthcare staff?. BMJ Open Quality, 13(3), Article e002830. https://doi.org/10.1136/bmjoq-2024-002830

Unprofessional behaviours (UBs) between healthcare staff are widespread and have negative impacts on patient safety, staff well-being and organisational efficiency. However, knowledge of how to address UBs is lacking. Our recent realist review analys... Read More about How can interventions more directly address drivers of unprofessional behaviour between healthcare staff?.

Driving quality in delirium care through a patient-centered monitoring system in palliative care: Protocol for the two-staged exploratory sequential mixed methods MODEL-PC study (2024)
Journal Article
van Oosterom, N., Agar, M. R., Walpole, G., Casey, P., Moffat, P., Bradley, K., Cook, A., Johnson, C., Chye, R., Oehme, J., Senatore, M., Virdun, C., Pearson, M., Featherstone, I., Lawlor, P. G., Bush, S. H., Daveson, B., Clapham, S., Campbell, K., & Hosie, A. (2024). Driving quality in delirium care through a patient-centered monitoring system in palliative care: Protocol for the two-staged exploratory sequential mixed methods MODEL-PC study. Delirium Communications, https://doi.org/10.56392/001c.94808

Introduction
Delirium is a serious acute neurocognitive condition that is common in palliative care units and yet under-addressed. To improve delirium care in this setting, we will develop and pilot a monitoring system that integrates the Delirium C... Read More about Driving quality in delirium care through a patient-centered monitoring system in palliative care: Protocol for the two-staged exploratory sequential mixed methods MODEL-PC study.

Developing a typology of interventions to support doctors’ mental health and wellbeing (2024)
Journal Article
Pearson, A., Carrieri, D., Melvin, A., Bramwell, C., Scott, J., Hancock, J., Papoutsi, C., Pearson, M., Wong, G., & Mattick, K. (2024). Developing a typology of interventions to support doctors’ mental health and wellbeing. BMC health services research, 24(1), Article 573. https://doi.org/10.1186/s12913-024-10884-6

Background: The problem of mental ill-health in doctors is complex, accentuated by the COVID-19 pandemic, and impacts on healthcare provision and broader organisational performance. There are many interventions to address the problem but currently no... Read More about Developing a typology of interventions to support doctors’ mental health and wellbeing.

Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care (2024)
Journal Article
Jackson, G. P., Jackson, C., Boland, J. W., Featherstone, I., Huang, C., Ogden, M., Sartain, K., Siddiqi, N., Twiddy, M., Pearson, M., & Johnson, M. J. (2024). Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care. Palliative medicine, 38(4), 447-456. https://doi.org/10.1177/02692163241236325

Background: Delirium is a complex condition, stressful for all involved. Although highly prevalent in palliative care settings, it remains underdiagnosed and associated with poor outcomes. Guideline-adherent delirium care may improve its detection, a... Read More about Improving the Detection, Assessment, Management and Prevention of Delirium in Hospices (the DAMPen-D study): Feasibility study of a flexible and scalable implementation strategy to deliver guideline-adherent delirium care.

Exploring pathways to optimise care in malignant bowel obstruction (EPOC): Protocol for a three-phase critical realist approach to theory-led intervention development for shared decision-making (2024)
Journal Article
Bravington, A., Boland, J. W., Greenley, S., Lind, M., Murtagh, F. E., Patterson, M., Pearson, M., & Johnson, M. J. (2024). Exploring pathways to optimise care in malignant bowel obstruction (EPOC): Protocol for a three-phase critical realist approach to theory-led intervention development for shared decision-making. PLoS ONE, 19(1 January), Article e0294218. https://doi.org/10.1371/journal.pone.0294218

Introduction Malignant bowel obstruction is a distressing complication of cancer, causing pain, nausea and vomiting, and often has a poor prognosis. Severe and rapidly developing symptoms, a lack of robust clinical guidelines and the need for multidi... Read More about Exploring pathways to optimise care in malignant bowel obstruction (EPOC): Protocol for a three-phase critical realist approach to theory-led intervention development for shared decision-making.