All Outputs (32)

Low-dose methotrexate: not the hepatotoxic medication we once thought (2023)
Thesis
Turner, L. V. B. (2023). Low-dose methotrexate: not the hepatotoxic medication we once thought. (Thesis). Hull York Medical School. https://hull-repository.worktribe.com/output/4443697

Methotrexate is a highly efficacious and frequently utilised disease-modifying medication. Concern regarding methotrexate-related hepatotoxicity has impeded the widespread application of the drug, despite a lack of high-quality evidence demonstrating... Read More about Low-dose methotrexate: not the hepatotoxic medication we once thought.

Intense Sweeteners, Taste Receptors and the Gut Microbiome: A Metabolic Health Perspective (2020)
Journal Article
Turner, A., Veysey, M., Keely, S., Scarlett, C. J., Lucock, M., & Beckett, E. L. (2020). Intense Sweeteners, Taste Receptors and the Gut Microbiome: A Metabolic Health Perspective. International Journal of Environmental Research and Public Health, 17(11), Article 4094. https://doi.org/10.3390/ijerph17114094

Intense sweeteners (IS) are often marketed as a healthier alternative to sugars, with the potential to aid in combating the worldwide rise of diabetes and obesity. However, their use has been counterintuitively associated with impaired glucose homeos... Read More about Intense Sweeteners, Taste Receptors and the Gut Microbiome: A Metabolic Health Perspective.

Independent and Interactive Influences of Environmental UVR, Vitamin D Levels, and Folate Variant MTHFD1-rs2236225 on Homocysteine Levels (2020)
Journal Article
Jones, P., Lucock, M., Martin, C., Thota, R., Garg, M., Yates, Z., Scarlett, C. J., Veysey, M., & Beckett, E. (2020). Independent and Interactive Influences of Environmental UVR, Vitamin D Levels, and Folate Variant MTHFD1-rs2236225 on Homocysteine Levels. Nutrients, 12(5), Article 1455. https://doi.org/10.3390/nu12051455

Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort (2020)
Journal Article
Ferraris, C., Turner, A., Kaur, K., Piper, J., Veysey, M., Lucock, M., & Beckett, E. L. (2020). Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort. Nutrients, 12(4), 1056. https://doi.org/10.3390/nu12041056

A small amount of emerging research has observed variations between individual sensitivity, preference and intake of salt in the presence of single nucleotide polymorphisms (SNP) on the genes encoding salt taste receptors. Sodium intake is a signific... Read More about Salt Taste Genotype, Dietary Habits and Biomarkers of Health: No Associations in an Elderly Cohort.

Distribution of variants in multiple vitamin D-related loci (DHCR7/NADSYN1, GC, CYP2R1, CYP11A1, CYP24A1, VDR, RXRα and RXRγ) vary between European, East-Asian and Sub-Saharan African-ancestry populations (2020)
Journal Article
Jones, P., Lucock, M., Chaplin, G., Jablonski, N. G., Veysey, M., Scarlett, C., & Beckett, E. (2020). Distribution of variants in multiple vitamin D-related loci (DHCR7/NADSYN1, GC, CYP2R1, CYP11A1, CYP24A1, VDR, RXRα and RXRγ) vary between European, East-Asian and Sub-Saharan African-ancestry populations. Genes and Nutrition, 15(1), Article 5. https://doi.org/10.1186/s12263-020-00663-3

Background
The frequency of vitamin D-associated gene variants appear to reflect changes in long-term ultraviolet B radiation (UVB) environment, indicating interactions exist between the primary determinant of vitamin D status, UVB exposure and gene... Read More about Distribution of variants in multiple vitamin D-related loci (DHCR7/NADSYN1, GC, CYP2R1, CYP11A1, CYP24A1, VDR, RXRα and RXRγ) vary between European, East-Asian and Sub-Saharan African-ancestry populations.

Environmental UVR Levels and Skin Pigmentation Gene Variants Associated with Folate and Homocysteine Levels in an Elderly Cohort (2020)
Journal Article
Jones, P., Lucock, M., Scarlett, C. J., Veysey, M., & Beckett, E. (2020). Environmental UVR Levels and Skin Pigmentation Gene Variants Associated with Folate and Homocysteine Levels in an Elderly Cohort. International Journal of Environmental Research and Public Health, 17(5), Article 1545. https://doi.org/10.3390/ijerph17051545

Ultraviolet radiation (UVR) is a ubiquitous exposure which may contribute to decreased folate levels. Skin pigmentation mediates the biological effect of UVR exposure, but its relationship to folate levels is unexamined. Interactions may exist betwee... Read More about Environmental UVR Levels and Skin Pigmentation Gene Variants Associated with Folate and Homocysteine Levels in an Elderly Cohort.

Interactions between taste receptors and the gastrointestinal microbiome in inflammatory bowel disease (2019)
Journal Article
Turner, A., Chijoff, E., Veysey, M., Keely, S., Scarlett, C. J., Lucock, M., & Beckett, E. L. (2019). Interactions between taste receptors and the gastrointestinal microbiome in inflammatory bowel disease. Journal of Nutrition and Intermediary Metabolism, 18, 100106. https://doi.org/10.1016/j.jnim.2019.100106

Incidence rates of inflammatory bowel disease (IBD) are increasing worldwide. This correlates with increased consumption of red meats, alcohol, refined sugars, oils and animal fats, typical of a “Western” diet. Poor dietary habits are the most ubiqui... Read More about Interactions between taste receptors and the gastrointestinal microbiome in inflammatory bowel disease.

Micronutrients and bioactive compounds in oral inflammatory diseases (2019)
Journal Article
Kaur, K., Sculley, D., Wallace, J., Turner, A., Ferraris, C., Veysey, M., Lucock, M., & Beckett, E. L. (2019). Micronutrients and bioactive compounds in oral inflammatory diseases. Journal of Nutrition and Intermediary Metabolism, 18, Article 100105. https://doi.org/10.1016/j.jnim.2019.100105

Oral disorders are a significant public health concern. Oral inflammatory diseases are periodontal infections, oral mucosal lesions, pulpal and periapical lesions. The aetiology is multi-factorial and usually associated with a microbial origin, often... Read More about Micronutrients and bioactive compounds in oral inflammatory diseases.

Folate and Inflammation – links between folate and features of inflammatory conditions (2019)
Journal Article
Jones, P., Lucock, M., Scarlett, C. J., Veysey, M., & Beckett, E. L. (2019). Folate and Inflammation – links between folate and features of inflammatory conditions. Journal of Nutrition and Intermediary Metabolism, 18, Article 100104. https://doi.org/10.1016/j.jnim.2019.100104

Folate serves as a cofactor for one-carbon (1C) transfer reactions. These reactions are involved in the synthesis of DNA nucleotides, the amino acid methionine, and in the regulation of homocysteine (Hcy) levels. Emerging evidence suggests that these... Read More about Folate and Inflammation – links between folate and features of inflammatory conditions.

Budesonide treatment for microscopic colitis: systematic review and meta-analysis (2019)
Journal Article
Sebastian, S., Wilhelm, A., Lisle, J., Myers, S., & Veysey, M. (2019). Budesonide treatment for microscopic colitis: systematic review and meta-analysis. European Journal of Gastroenterology and Hepatology, 31(8), 919–927. https://doi.org/10.1097/MEG.0000000000001456

Microscopic colitis (MC), encompassing lymphocytic and collagenous colitis, is a common cause for chronic nonbloody diarrhoea, which impacts significantly on the quality of life for patients. Despite increasing awareness of the condition and its trea... Read More about Budesonide treatment for microscopic colitis: systematic review and meta-analysis.

Early lifecycle UV‐exposure calibrates adult vitamin D metabolism: Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes (2019)
Journal Article
Lucock, M., Thota, R., Garg, M., Martin, C., Jones, P., Furst, J., Yates, Z., Jablonski, N. G., Chaplin, G., Veysey, M., & Beckett, E. (2019). Early lifecycle UV‐exposure calibrates adult vitamin D metabolism: Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes. American journal of human biology : the official journal of the Human Biology Council, 31(4), Article e23272. https://doi.org/10.1002/ajhb.23272

Objectives
Within the Developmental Origins of Adult Disease (DOHaD) model, early life environmental exposures can confer a long‐term legacy on human health. This mechanism may be adaptive or maladaptive depending on lifestyle circumstances. This ar... Read More about Early lifecycle UV‐exposure calibrates adult vitamin D metabolism: Evidence for a developmentally originated vitamin D homeostat that may alter related adult phenotypes.

Relationship between B-vitamin biomarkers and dietary intake with apolipoprotein E є4 in Alzheimer’s disease (2019)
Journal Article
D’Cunha, N. M., Georgousopoulou, E. N., Boyd, L., Veysey, M., Sturm, J., O’Brien, B., Lucock, M., McKune, A. J., Mellor, D. D., Roach, P. D., & Naumovski, N. (2019). Relationship between B-vitamin biomarkers and dietary intake with apolipoprotein E є4 in Alzheimer’s disease. Journal of Nutrition in Gerontology and Geriatrics, 38(2), 173-195. https://doi.org/10.1080/21551197.2019.1590287

The potential for B-vitamins to reduce plasma homocysteine (Hcy) and reduce the risk of Alzheimer’s disease (AD) has been described previously. However, the role of Apolipoprotein E є4 (APOE4) in this relationship has not been adequately addressed. T... Read More about Relationship between B-vitamin biomarkers and dietary intake with apolipoprotein E є4 in Alzheimer’s disease.

Population based study: atopy and autoimmune diseases are associated with functional dyspepsia and irritable bowel syndrome, independent of psychological distress (2019)
Journal Article
Koloski, N., Jones, M., Walker, M. M., Veysey, M., Zala, A., Keely, S., Holtmann, G., & Talley, N. J. (2019). Population based study: atopy and autoimmune diseases are associated with functional dyspepsia and irritable bowel syndrome, independent of psychological distress. Alimentary Pharmacology and Therapeutics, 49(5), 546-555. https://doi.org/10.1111/apt.15120

Background: The pathogenesis of functional GI disorders (FGIDs) is uncertain. However, underlying immune activation and psychological distress has been documented in irritable bowel syndrome (IBS) and functional dyspepsia (FD). Epidemiological data f... Read More about Population based study: atopy and autoimmune diseases are associated with functional dyspepsia and irritable bowel syndrome, independent of psychological distress.

Reply: “comment on: The vitamin D–folate hypothesis as an evolutionary model for skin pigmentation: An update and integration of current ideas, nutrients 2018, 10, 554” (2018)
Journal Article
Jones, P., Lucock, M., Veysey, M., & Beckett, E. (2018). Reply: “comment on: The vitamin D–folate hypothesis as an evolutionary model for skin pigmentation: An update and integration of current ideas, nutrients 2018, 10, 554”. Nutrients, 10(11), Article 1759. https://doi.org/10.3390/nu10111759

Interactions between bitter taste, diet and dysbiosis: Consequences for appetite and obesity (2018)
Journal Article
Turner, A., Veysey, M., Keely, S., Scarlett, C., Lucock, M., & Beckett, E. (2018). Interactions between bitter taste, diet and dysbiosis: Consequences for appetite and obesity. Nutrients, 10(10), Article 1336. https://doi.org/10.3390/nu10101336

The type 2 family of taste receptors (T2Rs) detect and respond to bitter tastants. These receptors are expressed throughout the gastrointestinal (GI) tract, with location dependant roles. In the oral cavity, T2Rs are involved in the conscious percept... Read More about Interactions between bitter taste, diet and dysbiosis: Consequences for appetite and obesity.

Vitamin D and folate: A reciprocal environmental association based on seasonality and genetic disposition (2018)
Journal Article
Lucock, M., Thota, R., Garg, M., Martin, C., Jones, P., Furst, J., Yates, Z., Jablonski, N., Chaplin, G., Veysey, M., Sutherland, J., & Beckett, E. (2018). Vitamin D and folate: A reciprocal environmental association based on seasonality and genetic disposition. American journal of human biology : the official journal of the Human Biology Council, 30(5), Article e23166. https://doi.org/10.1002/ajhb.23166

Objectives: The purpose of this study was (1) to elucidate any reciprocal seasonal relationship that might exist between red cell folate (RCF) and serum vitamin D3 Levels; (2) to explore whether folate-related gene variants that influence/alter DNA-t... Read More about Vitamin D and folate: A reciprocal environmental association based on seasonality and genetic disposition.

The vitamin D–folate hypothesis as an evolutionary model for skin pigmentation: An update and integration of current ideas (2018)
Journal Article
Jones, P., Lucock, M., Veysey, M., & Beckett, E. (2018). The vitamin D–folate hypothesis as an evolutionary model for skin pigmentation: An update and integration of current ideas. Nutrients, 10(5), Article 554. https://doi.org/10.3390/nu10050554

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Vitamin D is unique in being generated in our skin following ultraviolet radiation (UVR) exposure. Ongoing research into vitamin D must therefore always consider the influence of UVR on vitami... Read More about The vitamin D–folate hypothesis as an evolutionary model for skin pigmentation: An update and integration of current ideas.

Standard setting in Australian medical schools (2018)
Journal Article
Ward, H., Chiavaroli, N., Fraser, J., Mansfield, K., Starmer, D., Surmon, L., Veysey, M., & O'Mara, D. (2018). Standard setting in Australian medical schools. BMC Medical Education, 18(1), Article 80. https://doi.org/10.1186/s12909-018-1190-6

© 2018 The Author(s). Background: Standard setting of assessment is critical in quality assurance of medical programs. The aims of this study were to identify and compare the impact of methods used to establish the passing standard by the 13 medical... Read More about Standard setting in Australian medical schools.

Nutrigenetics—Personalized Nutrition in the Genetic Age (2017)
Journal Article
Beckett, E., Jones, P., Veysey, M., & Lucock, M. (2017). Nutrigenetics—Personalized Nutrition in the Genetic Age. Exploratory research and hypothesis in medicine, 2(4), 109-116. https://doi.org/10.14218/ERHM.2017.00027

Diet is an important modifiable determinant of disease, and it is becoming clear that diet and genetic risk factors are interactive in determining risk for diseases such as cardiovascular disease, diabetes and cancers. Advances in technology have imp... Read More about Nutrigenetics—Personalized Nutrition in the Genetic Age.

Frequency of folate-related polymorphisms varies by skin pigmentation (2017)
Journal Article
Jones, P., Lucock, M., Veysey, M., Jablonski, N., Chaplin, G., & Beckett, E. (2018). Frequency of folate-related polymorphisms varies by skin pigmentation. American Journal of Human Biology, 30(2), Article e23079. https://doi.org/10.1002/ajhb.23079

© 2017 Wiley Periodicals, Inc. Objectives: Folate-mediated 1-carbon transfer processes are vital in human health but are susceptible to independent and interactive influences of genetic variance and environmental exposures. Evidence suggests folate l... Read More about Frequency of folate-related polymorphisms varies by skin pigmentation.