All Outputs (65)

A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol (2019)
Journal Article
Wright, C., Hart, S. P., Allgar, V., English, A., Swan, F., Dyson, J., Richardson, G., Twiddy, M., Cohen, J., Hussain, J., Johnson, M., Hargreaves, I., & Crooks, M. G. (2019). A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol. ERJ Open Research, 5(4), Article 0186. https://doi.org/10.1183/23120541.00186-2019

Introduction: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease that causes breathlessness and cough that worsen over time, limiting daily activities and negatively impacting quality of life. Although treatments are now av... Read More about A feasibility, randomised controlled trial of a complex breathlessness intervention in idiopathic pulmonary fibrosis (BREEZE-IPF): study protocol.

Participant engagement with a UK community-based preschool childhood obesity prevention programme: a focused ethnography study (2019)
Journal Article
Burton, W., Twiddy, M., Sahota, P., Brown, J., & Bryant, M. (2019). Participant engagement with a UK community-based preschool childhood obesity prevention programme: a focused ethnography study. BMC public health, 19(1), Article 1074. https://doi.org/10.1186/s12889-019-7410-0

© 2019 The Author(s). Background: Children's centres in the UK provide a setting for public health programmes; offering support to families living in the most disadvantaged areas where obesity prevalence is at its highest. Health, Exercise and Nutrit... Read More about Participant engagement with a UK community-based preschool childhood obesity prevention programme: a focused ethnography study.

Patient and public involvement in health research in low and middle-income countries: a systematic review (2019)
Journal Article
Cook, N., Siddiqi, N., Twiddy, M., & Kenyon, R. (2019). Patient and public involvement in health research in low and middle-income countries: a systematic review. BMJ open, 9(5), Article e026514. https://doi.org/10.1136/bmjopen-2018-026514

Objectives: Patient and public involvement (PPI) is argued to lead to higher quality health research, which is more relatable to and helps empower the public. We synthesised the evidence to look for examples of PPI in health research in low/middle-in... Read More about Patient and public involvement in health research in low and middle-income countries: a systematic review.

High risk (B3) breast lesions: What is the incidence of malignancy for individual lesion subtypes? A systematic review and meta-analysis (2018)
Journal Article
Forester, N. D., Lowes, S., Mitchell, E., & Twiddy, M. (2019). High risk (B3) breast lesions: What is the incidence of malignancy for individual lesion subtypes? A systematic review and meta-analysis. European journal of surgical oncology, 45(4), 519-527. https://doi.org/10.1016/j.ejso.2018.12.008

© 2018 Introduction: Provide evidence to support evolving management strategies for high-risk (B3) breast lesions by assessing risk of carcinoma in subgroups of B3 lesions using systematic review and meta-analysis. Methods: Databases identified obser... Read More about High risk (B3) breast lesions: What is the incidence of malignancy for individual lesion subtypes? A systematic review and meta-analysis.

TIGA-CUB-manualised psychoanalytic child psychotherapy versus treatment as usual for children aged 5–11 with treatment-resistant conduct disorders and their primary carers: results from a randomised controlled feasibility trial (2018)
Journal Article
Edginton, E., Walwyn, R., Twiddy, M., Wright-Hughes, A., Tubeuf, S., Reed, S., Smith, A., Stubbs, L., Birtwistle, J., Abraham, S. J., Ellis, L., Midgley, N., Hughes, T., Wallis, P., & Cottrell, D. (2018). TIGA-CUB-manualised psychoanalytic child psychotherapy versus treatment as usual for children aged 5–11 with treatment-resistant conduct disorders and their primary carers: results from a randomised controlled feasibility trial. Journal of Child and Adolescent Mental Health, 30(3), 167-182. https://doi.org/10.2989/17280583.2018.1532433

Background: Parenting programmes are recommended for conduct disorders in 5–11 year olds, but ineffective for 25–33%. A feasibility trial was needed to determine whether a confirmatory trial of second-line, manualised short-term psychoanalytic child... Read More about TIGA-CUB-manualised psychoanalytic child psychotherapy versus treatment as usual for children aged 5–11 with treatment-resistant conduct disorders and their primary carers: results from a randomised controlled feasibility trial.

Liver resection surgery versus thermal ablation for colorectal LiVer MetAstases (LAVA): study protocol for a randomised controlled trial (2018)
Journal Article
Gurusamy, K., Corrigan, N., Croft, J., Twiddy, M., Morris, S., Woodward, N., Bandula, S., Hochhauser, D., Napp, V., Pullan, A., Jakowiw, N., Prasad, R., Damink, S. O., van Laarhoven, C. J., de Wilt, J. H., Brown, J., & Davidson, B. R. (2018). Liver resection surgery versus thermal ablation for colorectal LiVer MetAstases (LAVA): study protocol for a randomised controlled trial. Trials, 19(1), https://doi.org/10.1186/s13063-018-2499-5

Background:Although surgical resection has been considered the only curative option for colorectal livermetastases (CLM), thermal ablation has recently been suggested as an alternative curative treatment. A prospective randomised trial is required to... Read More about Liver resection surgery versus thermal ablation for colorectal LiVer MetAstases (LAVA): study protocol for a randomised controlled trial.

Feasibility of a multicentre, randomised controlled trial of laparoscopic versus open colorectal surgery in the acute setting: The LaCeS feasibility trial protocol (2018)
Journal Article
Harji, D., Marshall, H., Gordon, K., Crow, H., Hiley, V., Burke, D., Griffiths, B., Moriarty, C., Twiddy, M., O'Dwyer, J., Verjee, A., Brown, J., & Sagar, P. (2018). Feasibility of a multicentre, randomised controlled trial of laparoscopic versus open colorectal surgery in the acute setting: The LaCeS feasibility trial protocol. BMJ open, 8(2), Article e018618. https://doi.org/10.1136/bmjopen-2017-018618

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. Introduction Acute colorectal surgery forms a significant prop... Read More about Feasibility of a multicentre, randomised controlled trial of laparoscopic versus open colorectal surgery in the acute setting: The LaCeS feasibility trial protocol.

A qualitative study of patients’ feedback about Outpatient Parenteral Antimicrobial Therapy (OPAT) services in Northern England : implications for service improvement (2018)
Journal Article
Twiddy, M., Czoski Murray, C. J., Mason, S. J., Meads, D., Wright, J. M., Mitchell, E. D., & Minton, J. (2018). A qualitative study of patients’ feedback about Outpatient Parenteral Antimicrobial Therapy (OPAT) services in Northern England : implications for service improvement. BMJ open, 8(1), e019099. https://doi.org/10.1136/bmjopen-2017-019099

Abstract
Objective Outpatient parenteral antimicrobial therapy (OPAT) provides opportunities for improved cost savings, but in the UK, implementation is patchy and a variety of service models are in use. The slow uptake in the UK and Europe is due to... Read More about A qualitative study of patients’ feedback about Outpatient Parenteral Antimicrobial Therapy (OPAT) services in Northern England : implications for service improvement.

TIGA-CUB – manualised psychoanalytic child psychotherapy versus treatment as usual for children aged 5–11 years with treatment-resistant conduct disorders and their primary carers: study protocol for a randomised controlled feasibility trial (2017)
Journal Article
Edginton, E., Walwyn, R., Burton, K., Cicero, R., Graham, L., Reed, S., Tubeuf, S., Twiddy, M., Wright-Hughes, A., Ellis, L., Evans, D., Hughes, T., Midgley, N., Wallis, P., & Cottrell, D. (2017). TIGA-CUB – manualised psychoanalytic child psychotherapy versus treatment as usual for children aged 5–11 years with treatment-resistant conduct disorders and their primary carers: study protocol for a randomised controlled feasibility trial. Trials, 18(1), Article 431. https://doi.org/10.1186/s13063-017-2166-2

Background: The National Institute for Health and Care Excellence (NICE) recommends evidence-based parenting
programmes as a first-line intervention for conduct disorders (CD) in children aged 5–11 years. As these are not
effective in 25–33% of cases... Read More about TIGA-CUB – manualised psychoanalytic child psychotherapy versus treatment as usual for children aged 5–11 years with treatment-resistant conduct disorders and their primary carers: study protocol for a randomised controlled feasibility trial.

Radical cystectomy (bladder removal) against intravesical BCG immunotherapy for high-risk non-muscle invasive bladder cancer (BRAVO): a protocol for a randomised controlled feasibility study (2017)
Journal Article
Noon, A. P., Chahal, R., Dooldeniya, M., Koenig, P., Catto, J. W. F., Oughton, J. B., Poad, H., Twiddy, M., Collinson, M., Hiley, V., Gordon, K., Johnson, M., Jain, S., Noonan, A. P., Chalal, R., Simms, M., Dooldynia, M., Koening, P., Goodwin, L., Brown, J. M., & Catto, J. (2017). Radical cystectomy (bladder removal) against intravesical BCG immunotherapy for high-risk non-muscle invasive bladder cancer (BRAVO): a protocol for a randomised controlled feasibility study. BMJ open, 7(8), e017913. https://doi.org/10.1136/bmjopen-2017-017913

Introduction High-risk non-muscle invasive bladder cancer (HRNMIBC) is a heterogeneous disease that can be difficult to predict. While around 25% of cancers progress to invasion and metastases, the remaining majority of tumours remain within the blad... Read More about Radical cystectomy (bladder removal) against intravesical BCG immunotherapy for high-risk non-muscle invasive bladder cancer (BRAVO): a protocol for a randomised controlled feasibility study.

Cost-effectiveness of outpatient parenteral antibiotic therapy: a simulation modelling approach (2017)
Journal Article
Vargas-Palacios, A., Meads, D. M., Twiddy, M., Murray, C. C., Hulme, C., Mitchell, E. D., Gregson, A., Stanley, P., & Minton, J. (2017). Cost-effectiveness of outpatient parenteral antibiotic therapy: a simulation modelling approach. The journal of antimicrobial chemotherapy, 72(8), 2392-2400. https://doi.org/10.1093/jac/dkx123

© The Author 2017. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. Objectives: In the UK, patients who require intravenous antimicrobial (IVA) treatment may receive this in th... Read More about Cost-effectiveness of outpatient parenteral antibiotic therapy: a simulation modelling approach.

NIHR Liver/Renal Biomarker Programme Final Report: Evaluating the benefits for patients and the NHS of new and existing biological fluid biomarkers in liver and renal disease (2017)
Report
Selby, P., Banks, R., Gregory, W., Hewison, J., Rosenberg, W., Altman, D., Deeks, J. J., McCabe, C., Parkes, J., Sturgeon, C., Thompson, D., Twiddy, M., Bestall, J., Bedlington, J., Hale, T., Dinnes, J., Jones, M., Lewington, A., Messenger, M. P., Napp, V., …Hutchinson, M. (2017). NIHR Liver/Renal Biomarker Programme Final Report: Evaluating the benefits for patients and the NHS of new and existing biological fluid biomarkers in liver and renal disease. Southampton: NIHR

Protein biomarkers are naturally occurring substances that can be measured, often in fluids such as blood or urine, and which provide information about a patient and their illness. Different diseases have different biomarkers. When people become ill,... Read More about NIHR Liver/Renal Biomarker Programme Final Report: Evaluating the benefits for patients and the NHS of new and existing biological fluid biomarkers in liver and renal disease.

Clinical and cost-effectiveness, safety and acceptability of community intravenous antibiotic service models: CIVAS systematic review (2017)
Journal Article
Murray, C. C., Mitchell, E. D., Czoski Murray, C., Meads, D., Minton, J., Wright, J., & Twiddy, M. (2017). Clinical and cost-effectiveness, safety and acceptability of community intravenous antibiotic service models: CIVAS systematic review. BMJ open, 7(4), Article e013560. https://doi.org/10.1136/bmjopen-2016-013560

OBJECTIVE:
Evaluate evidence of the efficacy, safety, acceptability and cost-effectiveness of outpatient parenteral antimicrobial therapy (OPAT) models.
DESIGN:
A systematic review.
DATA SOURCES:
MEDLINE, EMBASE, CINAHL, Cochrane Library, National He... Read More about Clinical and cost-effectiveness, safety and acceptability of community intravenous antibiotic service models: CIVAS systematic review.

The patients’ experience of a bladder cancer diagnosis: a systematic review of the qualitative evidence (2017)
Journal Article
Edmondson, A. J., Birtwistle, J. C., Catto, J. W., & Twiddy, M. (2017). The patients’ experience of a bladder cancer diagnosis: a systematic review of the qualitative evidence. Journal of cancer survivorship : research and practice, 11(4), 453-461. https://doi.org/10.1007/s11764-017-0603-6

© 2017, The Author(s). Purpose: Bladder cancer (BC) is a common disease with disparate treatment options and variable outcomes. Despite the disease’s high prevalence, little is known of the lived experience of affected patients. National patient expe... Read More about The patients’ experience of a bladder cancer diagnosis: a systematic review of the qualitative evidence.

The Community IntraVenous Antibiotic Study (CIVAS): a mixed-methods evaluation of patient preferences for and cost-effectiveness of different service models for delivering outpatient parenteral antimicrobial therapy (2017)
Journal Article
Minton, J., Murray, C. C., Meads, D., Hess, S., Vargas-Palacios, A., Mitchell, E., Wright, J., Hulme, C., Raynor, D. K., Gregson, A., Stanley, P., McLintock, K., Vincent, R., & Twiddy, M. (2017). The Community IntraVenous Antibiotic Study (CIVAS): a mixed-methods evaluation of patient preferences for and cost-effectiveness of different service models for delivering outpatient parenteral antimicrobial therapy. Health Services and Delivery Research, 5(6), 1-272. https://doi.org/10.3310/hsdr05060

Background

Outpatient parenteral antimicrobial therapy (OPAT) is widely used in most developed countries, providing considerable opportunities for improved cost savings. However, it is implemented only partially in the UK, using a variety of servi... Read More about The Community IntraVenous Antibiotic Study (CIVAS): a mixed-methods evaluation of patient preferences for and cost-effectiveness of different service models for delivering outpatient parenteral antimicrobial therapy.

Altruism or obligation? The motivations and experience of women who donate oocytes to known recipients in assisted conception treatment: an interpretative phenomenological analysis study (2016)
Journal Article
Acharya, S., Bryant, L., & Twiddy, M. (2016). Altruism or obligation? The motivations and experience of women who donate oocytes to known recipients in assisted conception treatment: an interpretative phenomenological analysis study. Journal of Psychosomatic Obstetrics and Gynecology, 38(1), 4-11. https://doi.org/10.1080/0167482X.2016.1233171

© 2016 Informa UK Limited, trading as Taylor & Francis Group. Introduction: This qualitative study was conducted to explore the motivations and experience of oocyte donors donating to women known to them. Methods: Three women who donated oocytes to... Read More about Altruism or obligation? The motivations and experience of women who donate oocytes to known recipients in assisted conception treatment: an interpretative phenomenological analysis study.

Altruism or obligation? The motivations and experience of women who donate oocytes to known recipients in assisted conception treatment: An Interpretative Phenomenological Analysis study. (2016)
Journal Article
Arharya, S., Bryant, L. B., & Twiddy, M. (2017). Altruism or obligation? The motivations and experience of women who donate oocytes to known recipients in assisted conception treatment: An Interpretative Phenomenological Analysis study. Journal of Psychosomatic Obstetrics and Gynecology, 38(1), 4 - 11. https://doi.org/10.1080/0167482X.2016.1233171

Introduction: This qualitative study was conducted to explore the motivations and experience of oocyte donors donating to women known to them.

Methods: Three women who donated oocytes to a close relative were interviewed and data were analysed usi... Read More about Altruism or obligation? The motivations and experience of women who donate oocytes to known recipients in assisted conception treatment: An Interpretative Phenomenological Analysis study..

Diagnosis, medication, and surgical management for patients with trigeminal neuralgia: a qualitative study (2015)
Journal Article
Allsop, M. J., Twiddy, M., Grant, H., Czoski-Murray, C., Mon-Williams, M., Mushtaq, F., Phillips, N., Zakrzewska, J. M., & Pavitt, S. (2015). Diagnosis, medication, and surgical management for patients with trigeminal neuralgia: a qualitative study. Acta Neurochirurgica, 157(11), 1925-1933. https://doi.org/10.1007/s00701-015-2515-4

Background
Trigeminal neuralgia (TN) is a serious health problem, causing brief, recurrent episodes of stabbing or burning facial pain, which patients describe as feeling like an electric shock. The consequences of living with the condition are seve... Read More about Diagnosis, medication, and surgical management for patients with trigeminal neuralgia: a qualitative study.

Community IntraVenous Antibiotic Study (CIVAS): protocol for an evaluation of patient preferences for and cost-effectiveness of community intravenous antibiotic services (2015)
Journal Article
Czoski Murray, C., Twiddy, M., Meads, D., Hess, S., Wright, J., Mitchell, E. D., Hulme, C., Dodd, S., Gent, H., Gregson, A., McLintock, K., Raynor, D. K., Reynard, K., Stanley, P., Vincent, R., & Minton, J. (2015). Community IntraVenous Antibiotic Study (CIVAS): protocol for an evaluation of patient preferences for and cost-effectiveness of community intravenous antibiotic services. BMJ open, 5(8), Article e008965. https://doi.org/10.1136/bmjopen-2015-008965

Introduction: Outpatient parenteral antimicrobial therapy (OPAT) is used to treat a wide range of infections, and is common practice in countries such as the USA and Australia. In the UK, national guidelines (standards of care) for OPAT services have... Read More about Community IntraVenous Antibiotic Study (CIVAS): protocol for an evaluation of patient preferences for and cost-effectiveness of community intravenous antibiotic services.

Measuring patient-perceived continuity of care for patients with long-term conditions in primary care (2014)
Journal Article
Hill, K. M., Twiddy, M., Hewison, J., & House, A. O. (2014). Measuring patient-perceived continuity of care for patients with long-term conditions in primary care. BMC family practice, 15(1), Article 191. https://doi.org/10.1186/s12875-014-0191-8

Background: Continuity of care is widely acknowledged as important for patients with multi-morbidity but simple,
service-orientated indices cannot capture the full impact of continuity in complex care delivery systems. The patient’s
perspective is im... Read More about Measuring patient-perceived continuity of care for patients with long-term conditions in primary care.