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Agreement between blood draw techniques for assessing platelet activation by flow cytometry (2018)
Journal Article
Welch, E. L., Crooks, M. G., & Hart, S. P. (in press). Agreement between blood draw techniques for assessing platelet activation by flow cytometry. Platelets, 1-5. doi:10.1080/09537104.2018.1535705

It is widely believed that assays of platelet activation are susceptible to preanalytical variables related to blood draw technique. We assessed platelet activation by whole blood flow cytometry and investigated the effects of: (1) drawing blood into... Read More

Psychometric validation of the needs assessment tool: Progressive disease in interstitial lung disease (2017)
Journal Article
Johnson, M. J., Jamali, A., Ross, J., Fairhurst, C., Boland, J., Reigada, C., …Yorke, J. (2018). Psychometric validation of the needs assessment tool: Progressive disease in interstitial lung disease. Thorax, 73(9), 880-883. doi:10.1136/thoraxjnl-2017-210911

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. The inter-rater/test-retest reliability and construct validity... Read More

Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study (2017)
Journal Article
Walsh, S. L., Maher, T. M., Kolb, M., Poletti, V., Nusser, R., Richeldi, L., …Wells, A. (2017). Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: An international case-cohort study. The European respiratory journal, 50(2), doi:10.1183/13993003.00936-2017

We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts. A total of 1141 respiratory physicians and 34 IPF experts p... Read More

The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration? (2017)
Journal Article
Sadofsky, L. R., Hayman, Y. A., Williamson, J. D., Hart, S. P., & Morice, A. H. (2017). The effects of exogenous lipid on THP-1 cells : an in vitro model of airway aspiration?. Ers Monograph, 3(1), 00026-2016. doi:10.1183/23120541.00026-2016

Chronic inflammatory diseases of the airways are associated with gastro-oesophageal reflux (GOR) and aspiration events. The observation of lipid laden macrophages (LLM) within the airway may indicate aspiration secondary to GOR. The proposed mechanis... Read More

Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis (2016)
Journal Article
Fraser, S. D., Sadofsky, L. R., Kaye, P. M., & Hart, S. P. (2016). Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis. Scientific reports, 6(1), doi:10.1038/srep38689. ISSN 2045-2322

In sarcoidosis, the proinflammatory cytokines interferon gamma, tumour necrosis factor and interleukin-6 are released by monocyte-derived macrophages and lymphocytes in the lungs and other affected tissues. Regulatory receptors expressed on monocytes... Read More

Coagulation and anticoagulation in idiopathic pulmonary fibrosis (2015)
Journal Article
Crooks, M. G., & Hart, S. P. (2015). Coagulation and anticoagulation in idiopathic pulmonary fibrosis. European Respiratory Review, 24(137), (392-399). doi:10.1183/16000617.00008414. ISSN 0905-9180

Idiopathic pulmonary fibrosis (IPF) is an incurable, progressive interstitial lung disease with a prognosis that is worse than that of many cancers. Epidemiological studies have demonstrated a link between IPF and thrombotic vascular events. Coagulat... Read More

Increased platelet reactivity in idiopathic pulmonary fibrosis is mediated by a plasma factor (2014)
Journal Article
Crooks, M. G., Naseem, K. M., Morice, A. H., Hart, S. P., Crooks, M., Hart, S., …Fahim, A. (2014). Increased platelet reactivity in idiopathic pulmonary fibrosis is mediated by a plasma factor. PloS one, 9(10), (e111347). doi:10.1371/journal.pone.0111347. ISSN 1932-6203

Introduction Idiopathic Pulmonary Fibrosis (IPF) is a progressive, incurable fibrotic interstitial lung disease with a prognosis worse than many cancers. Its pathogenesis is poorly understood. Activated platelets can release pro-fibrotic mediators th... Read More

Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis. (2014)
Journal Article
Crooks, M. G., Morice, A. H., Hart, S. P., Crooks, M., Hart, S., Morice, A., & Fahim, A. (2014). Increased platelet binding to circulating monocytes in idiopathic pulmonary fibrosis. Lung, 192(2), (277-284). doi:10.1007/s00408-013-9546-5. ISSN 0341-2040

Purpose Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonia and its prognosis is poor. Epidemiological evidence suggests an association of IPF with vascular disease and thrombotic tendency, which may be related to... Read More

Idiopathic Pulmonary Fibrosis is Associated with Circulating Antiepithelial Antibodies (2012)
Journal Article
Fahim, A., Chong, M. C., Crooks, M. G., & Hart, S. P. (2012). Idiopathic Pulmonary Fibrosis is Associated with Circulating Antiepithelial Antibodies. Lung, 190(4), 451-458. doi:10.1007/s00408-012-9390-z

PurposeIdiopathic pulmonary fibrosis (IPF) is a restrictive fibrotic lung disease of uncertain etiology. Alveolar epithelial injury may be one of the inciting triggers in the pathogenesis of this disorder. We hypothesized that circulating antibodies... Read More

Characterization of the effects of cross-linking of macrophage CD44 associated with increased phagocytosis of apoptotic PMN (2012)
Journal Article
Hart, S. P., Dransfield, I., Haslett, C., & Rossi, A. G. (2012). Characterization of the effects of cross-linking of macrophage CD44 associated with increased phagocytosis of apoptotic PMN. PloS one, 7(3), (e33142). doi:10.1371/journal.pone.0033142. ISSN 1932-6203

Control of macrophage capacity for apoptotic cell clearance by soluble mediators such as cytokines, prostaglandins and lipoxins, serum proteins, and glucocorticoids may critically determine the rate at which inflammation resolves. Previous studies su... Read More

Copy number variation of FCGR3B is associated with susceptibility to idiopathic pulmonary fibrosis (2010)
Journal Article
Bournazos, S., Bournazou, I., Murchison, J. T., Wallace, W. A., McFarlane, P., Hirani, N., …Hart, S. P. (2011). Copy number variation of FCGR3B is associated with susceptibility to idiopathic pulmonary fibrosis. Respiration, 81(2), (142-149). doi:10.1159/000321997. ISSN 0025-7931

Background: Several genes exhibit copy number variation (CNV), including FCGR3B which encodes the IgG receptor FcγRIIIb. Engagement of Fcγ receptors by IgG complexes may contribute to the pathogenesis of idiopathic pulmonary fibrosis (IPF). Objective... Read More

Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression (2010)
Journal Article
Hart, S. P., Wallace, W. A., Murchison, J. T., Alexander, K. M., Dransfield, I., Simpson, A. J., …Hart, S. P. (2010). Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression. BMC Pulmonary Medicine, 10(1), doi:10.1186/1471-2466-10-51

Background: A significant genetic component has been described for idiopathic pulmonary fibrosis (IPF). The R131H (rs1801274) polymorphism of the IgG receptor FcγRIIa determines receptor affinity for IgG subclasses and is associated with several chro... Read More

Fcγ Receptor IIIb (CD16b) Polymorphisms are Associated with Susceptibility to Idiopathic Pulmonary Fibrosis (2010)
Journal Article
Hart, S. P., Bournazos, S., Bournazou, I., Dransfield, I., Hirani, N., McFarlane, P., …Wallace, W. A. (2010). Fcγ Receptor IIIb (CD16b) Polymorphisms are Associated with Susceptibility to Idiopathic Pulmonary Fibrosis. Lung, 188(6), (475-481). doi:10.1007/s00408-010-9262-3. ISSN 0341-2040

An excess of neutrophils in the alveoli and lung interstitium has been described in idiopathic pulmonary fibrosis (IPF). Engagement of neutrophil Fcγ receptors with IgG complexes may contribute to the pathogenesis of IPF. The neutrophil FcγRIIIb rece... Read More