All Outputs (270)

Androsterone glucuronide to dehydroepiandrosterone sulphate ratio is discriminatory for obese Caucasian women with polycystic ovary syndrome (2017)
Journal Article
Cho, L. W., Sathyapalan, T., Kilpatrick, E. S., Keevil, B. G., Miller, A. G., Coady, A. M., Ahmed, L., & Atkin, S. L. (2017). Androsterone glucuronide to dehydroepiandrosterone sulphate ratio is discriminatory for obese Caucasian women with polycystic ovary syndrome. BMC Endocrine Disorders, 17(1), Article 26. https://doi.org/10.1186/s12902-017-0177-3

BACKGROUND: Androsterone glucuronide (ADTG) concentrations have been suggested as a marker of the effects of androgens at the target tissue level. As the mechanism for hyperandrogenemia in obese and nonobese polycystic ovary syndrome (PCOS) may diffe... Read More about Androsterone glucuronide to dehydroepiandrosterone sulphate ratio is discriminatory for obese Caucasian women with polycystic ovary syndrome.

Effects of dietary polyphenols on vascular endothelium and cardiovascular health (2017)
Thesis
Ehtesham, E. (2017). Effects of dietary polyphenols on vascular endothelium and cardiovascular health. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4219556

Introduction: Polyphenols have been suggested as being able to modulate the risk of cardiovascular disease. However, the molecular mechanisms underlying these effects are unclear and the literature lacks consistency and reproducibility, with in vitro... Read More about Effects of dietary polyphenols on vascular endothelium and cardiovascular health.

Soy protein improves cardiovascular risk in subclinical hypothyroidism : a randomized double-blinded crossover study (2017)
Journal Article
Sathyapalan, T., Javed, Z., Rigby, A. S., Kilpatrick, E. S., & Atkin, S. L. (2017). Soy protein improves cardiovascular risk in subclinical hypothyroidism : a randomized double-blinded crossover study. Journal of the Endocrine Society, 1(5), 423-430. https://doi.org/10.1210/js.2016-1068

© 2017 Endocrine Society. Background: Soy protein with isoflavones appears to have an adverse effect on thyroid function, but it is not known whether it is the protein or isoflavone component that is deleterious. The effect of isoflavone-free soy on... Read More about Soy protein improves cardiovascular risk in subclinical hypothyroidism : a randomized double-blinded crossover study.

Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study (2016)
Journal Article
Sathyapalan, T., Rigby, A. S., Bhasin, S., Thatcher, N. J., Kilpatrick, E. S., & Atkin, S. L. (2017). Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study. Journal of Clinical Endocrinology and Metabolism, 102(2), 425-433. https://doi.org/10.1210/jc.2016-2875

Context: Isoflavones found in soy products have a chemical structure similar to estrogen, leading to concerns of an adverse estrogenic effect in men, particularly in those with type 2 diabetes mellitus (T2DM) who have low testosterone levels due to h... Read More about Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: a randomised controlled study.

Determination of deoxynivalenol in the urine of pregnant women in the UK (2016)
Journal Article
Rigby, A., Sathyapalan, T., Wells, L., Atkin, S., Brera, C., De Santis, B., Debegnach, F., Greetham, S., Hardie, L., Liu, Y., Moretti, G., White, K., & Williams, C. (2016). Determination of deoxynivalenol in the urine of pregnant women in the UK. Toxins, 8(11), 306. https://doi.org/10.3390/toxins8110306

Deoxynivalenol (DON) is one of the most commonly occurring trichothecenes, produced mainly by Fusarium graminearum. Little is known about the effect of DON exposure or the levels of DON exposure that occur during pregnancy. The project aimed to provi... Read More about Determination of deoxynivalenol in the urine of pregnant women in the UK.

The repeatability of the abbreviated (4-h) Oral Fat Tolerance Test and influence of prior acute aerobic exercise (2016)
Journal Article
O’Doherty, A. F., Sathyapalan, T., Rigby, A. S., Ingle, L., & Carroll, S. (2018). The repeatability of the abbreviated (4-h) Oral Fat Tolerance Test and influence of prior acute aerobic exercise. European Journal of Nutrition, 57(1), 309-318. https://doi.org/10.1007/s00394-016-1320-z

© 2016 The Author(s) Purpose: The Oral Fat Tolerance Test (OFTT) is regarded as a repeatable measure used to assess postprandial triglyceride (TAG) levels, with higher levels observed in cardio-metabolic disorders. Acute aerobic exercise intervention... Read More about The repeatability of the abbreviated (4-h) Oral Fat Tolerance Test and influence of prior acute aerobic exercise.

Modelling aspects of oviduct fluid formation in vitro (2016)
Journal Article
Simintiras, C. A., Arnold, G. J., Ulbrich, S. E., Leese, H. J., Sturmey, R. G., Froehlich, T., Leese, H., Sathyapalan, T., Sturmey, R., Arnold, G., Fröhlich, T., & Ulbrich, S. (2017). Modelling aspects of oviduct fluid formation in vitro. Reproduction, 153(1), 23-33. https://doi.org/10.1530/REP-15-0508

© 2017 Society for Reproduction and Fertility. Oviduct fluid is the microenvironment that supports early reproductive processes including fertilisation, embryo cleavage and genome activation. However, the composition and regulation of this critical e... Read More about Modelling aspects of oviduct fluid formation in vitro.

Endocannabinoid receptor blockade increases vascular endothelial growth factor and inflammatory markers in obese women with polycystic ovary syndrome (2016)
Journal Article
Javed, Z., Sathyapalan, T., Atkin, S. L., Coady, A.-M., & Kilpatrick, E. S. (2017). Endocannabinoid receptor blockade increases vascular endothelial growth factor and inflammatory markers in obese women with polycystic ovary syndrome. Clinical Endocrinology, 86(3), 384-387. https://doi.org/10.1111/cen.13239

© 2016 John Wiley & Sons Ltd Context: Animal studies suggest that cannabinoid receptor-1 (CB-1) blockade reduces inflammation and neovascularization by decreasing vascular endothelial growth factor (VEGF) levels associated with a reduction in infla... Read More about Endocannabinoid receptor blockade increases vascular endothelial growth factor and inflammatory markers in obese women with polycystic ovary syndrome.

Developing a novel in vitro preparation to study the mechanisms underlying oviduct fluid formation in health and disease (2016)
Thesis
Simintiras, C. A. (2016). Developing a novel in vitro preparation to study the mechanisms underlying oviduct fluid formation in health and disease. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4223616

Soy reduces bone turnover markers in women during early menopause: a randomized controlled trial (2016)
Journal Article
Sathyapalan, T., Aye, M., Rigby, A. S., Fraser, W. D., Thatcher, N. J., Kilpatrick, E. S., & Atkin, S. L. (2017). Soy reduces bone turnover markers in women during early menopause: a randomized controlled trial. Journal of Bone and Mineral Research, 32(1), 157-164. https://doi.org/10.1002/jbmr.2927

Menopausal estrogen loss leads to an increased bone loss. Soy isoflavones can act as selective estrogen receptor modulators, their role in bone turnover is unclear. The primary outcome was assessing changes in plasma bone turnover markers. The second... Read More about Soy reduces bone turnover markers in women during early menopause: a randomized controlled trial.

Pilot investigation of a virtual gastric band hypnotherapy intervention (2016)
Journal Article
Greetham, S., Goodwin, S., Wells, L., Whitham, C., Jones, H., Rigby, A., Sathyapalan, T., Reid, M., & Atkin, S. (2016). Pilot investigation of a virtual gastric band hypnotherapy intervention. International Journal of Clinical and Experimental Hypnosis, 64(4), 419-433. https://doi.org/10.1080/00207144.2016.1209037

This was a pilot investigation of 30 men and women with a BMI > 27kg/m² over a 24 week period. It aimed to determine whether virtual gastric band (VGB) hypnotherapy has an effect on weight loss in overweight adults, compared to relaxation hypnotherap... Read More about Pilot investigation of a virtual gastric band hypnotherapy intervention.

Prevalence of glucometabolic disorders in acute coronary syndrome and their prognostic influence in long term cardiovascular outcome (2016)
Thesis
George, A. (2016). Prevalence of glucometabolic disorders in acute coronary syndrome and their prognostic influence in long term cardiovascular outcome. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4218888

Endocannabinoid receptor blockade increases hepatocyte growth factor and reduces insulin levels in obese women with polycystic ovary syndrome (2016)
Journal Article
Sathyapalan, T., Dakroury, Y., Ahmed, L., Elshewehy, A. M. M., Kilpatrick, E. S., Coady, A.-M., & Atkin, S. L. (2016). Endocannabinoid receptor blockade increases hepatocyte growth factor and reduces insulin levels in obese women with polycystic ovary syndrome. Clinical Endocrinology, 85(4), 671-673. https://doi.org/10.1111/cen.13120

There is evidence from animal and in-vitro studies that activation of the endocannabinoid system (EC) through cannabinoid receptor 1 (CB-1) is associated with liver injury, inflammation and hepatocellular carcinoma.1 Data suggests endogenous cannabin... Read More about Endocannabinoid receptor blockade increases hepatocyte growth factor and reduces insulin levels in obese women with polycystic ovary syndrome.

Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis (2015)
Journal Article
Sathyapalan, T., Atkin, S. L., David, R., & Gooderham, N. J. (2015). Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis. Scientific reports, 5(1), 16890-1-16890-8. https://doi.org/10.1038/srep16890

MicroRNAs (miRNA) are a novel class of small noncoding single-stranded RNA molecules that regulate gene expression. There is increasing evidence of their importance in polycystic ovary syndrome (PCOS). The objective was to determine if miRNA-93 and m... Read More about Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis.

Sporopollenin, the least known yet toughest natural biopolymer (2015)
Journal Article
Mackenzie, G., Boa, A. N., Diego-Taboada, A., Atkin, S. L., & Sathyapalan, T. (2015). Sporopollenin, the least known yet toughest natural biopolymer. Frontiers in Materials, 2, 1-5. https://doi.org/10.3389/fmats.2015.00066

© 2015 Mackenzie, Boa, Diego-Taboada, Atkin and Sathyapalan. Sporopollenin is highly cross-linked polymer composed of carbon, hydrogen, and oxygen that is extraordinarily stable and has been found chemically intact in sedimentary rocks some 500 milli... Read More about Sporopollenin, the least known yet toughest natural biopolymer.

Impaired glucose tolerance or newly diagnosed diabetes mellitus diagnosed during admission adversely affects prognosis after myocardial infarction: An observational study (2015)
Journal Article
George, A., Bhatia, R. T., Buchanan, G. L., Whiteside, A., Moisey, R. S., Beer, S. F., Chattopadhyay, S., Sathyapalan, T., & John, J. (2015). Impaired glucose tolerance or newly diagnosed diabetes mellitus diagnosed during admission adversely affects prognosis after myocardial infarction: An observational study. PLoS ONE, 10(11), e0142045. https://doi.org/10.1371/journal.pone.0142045

Objective To investigate the prognostic effect of newly diagnosed diabetes mellitus (NDM) and impaired glucose tolerance (IGT) post myocardial infarction (MI). Research Design and Methods Retrospective cohort study of 768 patients without preexisting... Read More about Impaired glucose tolerance or newly diagnosed diabetes mellitus diagnosed during admission adversely affects prognosis after myocardial infarction: An observational study.

Aspartame sensitivity? : a double blind randomised crossover study (2015)
Journal Article
Sathyapalan, T., Thatcher, N. J., Hammersley, R., Rigby, A. S., Pechlivanis, A., Gooderham, N. J., Holmes, E., Le Roux, C. W., Atkin, S. L., & Courts, F. (2015). Aspartame sensitivity? : a double blind randomised crossover study. PLoS ONE, 10(3), e0116212. https://doi.org/10.1371/journal.pone.0116212

Background Aspartame is a commonly used intense artificial sweetener, being approximately 200 times sweeter than sucrose. There have been concerns over aspartame since approval in the 1980s including a large anecdotal database reporting severe sympto... Read More about Aspartame sensitivity? : a double blind randomised crossover study.

Insulin resistance and cardiovascular risk marker evaluation in morbid obesity 12 months after bariatric surgery compared to weight-matched controls (2013)
Journal Article
Dawson, A. J., Sathyapalan, T., Sedman, P., Ajjan, R., Kilpatrick, E. S., & Atkin, S. L. (2014). Insulin resistance and cardiovascular risk marker evaluation in morbid obesity 12 months after bariatric surgery compared to weight-matched controls. Obesity Surgery, 24(3), 349-358. https://doi.org/10.1007/s11695-013-1100-2

Background Insulin resistance (IR) after bariatric surgery is significantly lower than controls matched for bodymass index (BMI) and is indistinguishable from lean subjects however it is not known if this is the same for associated cardiovascular ris... Read More about Insulin resistance and cardiovascular risk marker evaluation in morbid obesity 12 months after bariatric surgery compared to weight-matched controls.

GLP-1R, a novel receptor in platelets; and the use of liraglutide in the treatment of obesity in women with PCOS (2013)
Thesis
Kahal, H. (2013). GLP-1R, a novel receptor in platelets; and the use of liraglutide in the treatment of obesity in women with PCOS. (Thesis). Hull York Medical School, the University of Hull and the University of York. Retrieved from https://hull-repository.worktribe.com/output/4215983

Studies investigating atherothrombotic risk in women with polycystic ovary syndrome (PCOS), in particular platelet function and carotid intima-media wall thickness (cIMT), have been confounded by not adequately accounting for obesity. Liraglutide is... Read More about GLP-1R, a novel receptor in platelets; and the use of liraglutide in the treatment of obesity in women with PCOS.

A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease (2013)
Journal Article
Dawson, A. J., Sathyapalan, T., Smithson, J. A. J., Vince, R. V., Coady, A. M., Ajjan, R., Kilpatrick, E. S., & Atkin, S. L. (2014). A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease. Clinical Endocrinology, 80(6), 843-849. https://doi.org/10.1111/cen.12258

Background Women with polycystic ovary syndrome (PCOS) have an adverse cardiovascular risk profile and an increased prevalence of nonalcoholic fatty liver disease (NAFLD), which is also associated with an adverse cardiovascular risk profile. Objectiv... Read More about A comparison of cardiovascular risk indices in patients with polycystic ovary syndrome with and without coexisting nonalcoholic fatty liver disease.