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All Outputs (162)

Open urethroplasty versus endoscopic urethrotomy for recurrent urethral stricture in men: the OPEN RCT (2020)
Journal Article
Pickard, R., Goulao, B., Carnell, S., Shen, J., MacLennan, G., Norrie, J., Breckons, M., Vale, L., Whybrow, P., Rapley, T., Forbes, R., Currer, S., Forrest, M., Wilkinson, J., McColl, E., Andrich, D., Barclay, S., Cook, J., Mundy, A., N’Dow, J., …Watkin, N. (in press). Open urethroplasty versus endoscopic urethrotomy for recurrent urethral stricture in men: the OPEN RCT. Health Technology Assessment, 24(61), 1-110. https://doi.org/10.3310/hta24610

Background: Men who suffer recurrence of bulbar urethral stricture have to decide between endoscopic urethrotomy and open urethroplasty to manage their urinary symptoms. Evidence of relative clinical effectiveness and cost-effectiveness is lacking.... Read More about Open urethroplasty versus endoscopic urethrotomy for recurrent urethral stricture in men: the OPEN RCT.

Historical epistemology of the 'unitary psychosis' (2020)
Book Chapter
Berrios, G., & Markova, I. (2021). Historical epistemology of the 'unitary psychosis'. In C. A. Tamminga (ed. ), J. van Os, U. Reininghaus, & E. Ivleva (Eds.), Psychotic Disorders: Comprehensive Conceptualization and Treatments (12-20). Oxford University Press. https://doi.org/10.1093/med/9780190653279.003.0002

This chapter identifies and discusses the central and supporting concepts that seem to have participated in the construction of the concept of unitary psychosis. It proposes that concepts can be organized in terms of a simplified three-strata model t... Read More about Historical epistemology of the 'unitary psychosis'.

A historical perspective on neurological and neuropsychiatric definitions (2020)
Book Chapter
Berrios, G., & Markova, I. (2021). A historical perspective on neurological and neuropsychiatric definitions. In C. Brayne, V. L. Feigin, L. J. Launer, & G. Logroscino (Eds.), Oxford Textbook of Neurologic and Neuropsychiatric Epidemiology (3-8). Oxford University Press. https://doi.org/10.1093/med/9780198749493.003.0001

Taking a historical epistemological perspective, this chapter explores how neurology and neuropsychiatry were constructed. As a medical specialism developing in the 19th century, neurology resulted from the convergence of: (1) the term ‘neurology’; (... Read More about A historical perspective on neurological and neuropsychiatric definitions.

CANcer BEhavioural nutrition and exercise feasibility trial (CanBenefit); phase I qualitative interview findings (2020)
Journal Article
Swan, F., Chen, H., Forbes, C. C., Johnson, M. J., & Lind, M. (in press). CANcer BEhavioural nutrition and exercise feasibility trial (CanBenefit); phase I qualitative interview findings. Journal of Geriatric Oncology, https://doi.org/10.1016/j.jgo.2020.09.026

Background: Older people with lung cancer are often frail and unfit due to their cancer and co-morbidities and may tolerate cancer treatments poorly. Physical activity (PA) and a healthy diet offer quality of life benefit to people with cancer before... Read More about CANcer BEhavioural nutrition and exercise feasibility trial (CanBenefit); phase I qualitative interview findings.

Yorkshire Lung Screening Trial (YLST): protocol for a randomised controlled trial to evaluate invitation to community-based low-dose CT screening for lung cancer versus usual care in a targeted population at risk (2020)
Journal Article
Crosbie, P. A., Gabe, R., Simmonds, I., Kennedy, M., Rogerson, S., Ahmed, N., Baldwin, D. R., Booton, R., Cochrane, A., Darby, M., Franks, K., Hinde, S., Janes, S. M., Macleod, U., Messenger, M., Moller, H., Murray, R. L., Neal, R. D., Quaife, S. L., Sculpher, M., …Callister, M. E. (2020). Yorkshire Lung Screening Trial (YLST): protocol for a randomised controlled trial to evaluate invitation to community-based low-dose CT screening for lung cancer versus usual care in a targeted population at risk. BMJ open, 10(9), Article e037075. https://doi.org/10.1136/bmjopen-2020-037075

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. INTRODUCTION: Lung cancer is the world's leading cause of cancer death. Low-dose computed tomography (LDCT) screening reduced lung cancer mortality by 20% in the... Read More about Yorkshire Lung Screening Trial (YLST): protocol for a randomised controlled trial to evaluate invitation to community-based low-dose CT screening for lung cancer versus usual care in a targeted population at risk.

Avoiding harm: Tackling problematic polypharmacy through strengthening expert generalist practice (2020)
Journal Article
Reeve, J. (in press). Avoiding harm: Tackling problematic polypharmacy through strengthening expert generalist practice. British Journal of Clinical Pharmacology, https://doi.org/10.1111/bcp.14531

Problematic polypharmacy is a growing challenge. Medication that is intended to improve patients' health and wellbeing is instead becoming part of the problem. The way we practice medicine has become a driver for the problem. Dealing with the challen... Read More about Avoiding harm: Tackling problematic polypharmacy through strengthening expert generalist practice.

Surgical Treatment for Recurrent Bulbar Urethral Stricture: A Randomised Open-label Superiority Trial of Open Urethroplasty Versus Endoscopic Urethrotomy (the OPEN Trial) (2020)
Journal Article
Goulao, B., Carnell, S., Shen, J., MacLennan, G., Norrie, J., Cook, J., …Pickard, R. (2020). Surgical Treatment for Recurrent Bulbar Urethral Stricture: A Randomised Open-label Superiority Trial of Open Urethroplasty Versus Endoscopic Urethrotomy (the OPEN Trial). European Urology, 78(4), 572-580. https://doi.org/10.1016/j.eururo.2020.06.003

Background Urethral stricture affects 0.9% of men. Initial treatment is urethrotomy. Approximately, half of the strictures recur within 4 yr. Options for further treatment are repeat urethrotomy or open urethroplasty. Objective To compare the effe... Read More about Surgical Treatment for Recurrent Bulbar Urethral Stricture: A Randomised Open-label Superiority Trial of Open Urethroplasty Versus Endoscopic Urethrotomy (the OPEN Trial).

REDUCE (Reviewing long-term antidepressant use by careful monitoring in everyday practice) internet and telephone support to people coming off long-term antidepressants: Protocol for a randomised controlled trial (2020)
Journal Article
Kendrick, T., Geraghty, A. W., Bowers, H., Stuart, B., Leydon, G., May, C., Yao, G., O'Brien, W., Glowacka, M., Holley, S., Williams, S., Zhu, S., Dewar-Haggart, R., Palmer, B., Bell, M., Collinson, S., Fry, I., Lewis, G., Griffiths, G., Gilbody, S., …Dowrick, C. (2020). REDUCE (Reviewing long-term antidepressant use by careful monitoring in everyday practice) internet and telephone support to people coming off long-term antidepressants: Protocol for a randomised controlled trial. Trials, 21(1), Article 419. https://doi.org/10.1186/s13063-020-04338-7

© 2020 The Author(s). Background: Around one in ten adults take antidepressants for depression in England, and their long-term use is increasing. Some need them to prevent relapse, but 30-50% could possibly stop them without relapsing and avoid adver... Read More about REDUCE (Reviewing long-term antidepressant use by careful monitoring in everyday practice) internet and telephone support to people coming off long-term antidepressants: Protocol for a randomised controlled trial.

Supporting social prescribing in primary care by linking people to local assets: A realist review (2020)
Journal Article
Tierney, S., Wong, G., Roberts, N., Boylan, A. M., Park, S., Abrams, R., Reeve, J., Williams, V., & Mahtani, K. R. (2020). Supporting social prescribing in primary care by linking people to local assets: A realist review. BMC medicine, 18(1), Article 49. https://doi.org/10.1186/s12916-020-1510-7

© 2020 The Author(s). Background: Social prescribing is a way of addressing the 'non-medical' needs (e.g. loneliness, debt, housing problems) that can affect people's health and well-being. Connector schemes (e.g. delivered by care navigators or link... Read More about Supporting social prescribing in primary care by linking people to local assets: A realist review.

'Unpacking' pathways to lymphoma and myeloma diagnosis: Do experiences align with the Model of Pathways to Treatment? Findings from a UK qualitative study with patients and relatives (2020)
Journal Article
Howell, D., Hart, R., Smith, A., MacLeod, U., Patmore, R., & Roman, E. (2020). 'Unpacking' pathways to lymphoma and myeloma diagnosis: Do experiences align with the Model of Pathways to Treatment? Findings from a UK qualitative study with patients and relatives. BMJ open, 10(2), Article e034244. https://doi.org/10.1136/bmjopen-2019-034244

© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. Objectives To explore alignment of experiences before lymphoma and myeloma diagnosis with the appraisal, help seeking and diagnostic intervals in the Model of Pa... Read More about 'Unpacking' pathways to lymphoma and myeloma diagnosis: Do experiences align with the Model of Pathways to Treatment? Findings from a UK qualitative study with patients and relatives.

Palliative care for non-cancer conditions in primary care: a time trend analysis in the UK (2009–2014) (2020)
Journal Article
Gadoud, A., Kane, E., Oliver, S. E., Johnson, M. J., MacLeod, U., & Allgar, V. (2020). Palliative care for non-cancer conditions in primary care: a time trend analysis in the UK (2009–2014). BMJ supportive & palliative care, Article 001833. https://doi.org/10.1136/bmjspcare-2019-001833

Objectives While guidelines recommend palliative care in non-cancer conditions, this has not been widely implemented. We examined whether the recording of a palliative care approach and the numbers of hospital deaths for deceased patients with heart... Read More about Palliative care for non-cancer conditions in primary care: a time trend analysis in the UK (2009–2014).

What do the healthcare experiences of people with long-term conditions tell us about person-centred care? A systematic review. (2019)
Journal Article
Dell Olio, M., Pask, S., Seymour, J., & Reeve, J. (2019). What do the healthcare experiences of people with long-term conditions tell us about person-centred care? A systematic review. European journal for person centered healthcare, 7(4),

Introduction Growing numbers of people now live with long term conditions. For each person, the challenges are multiple and unique to that individual. In recognition of this, health policy places greater emphasis on the delivery of person-centred ca... Read More about What do the healthcare experiences of people with long-term conditions tell us about person-centred care? A systematic review..

Non-attendance at urgent referral appointments for suspected cancer: A qualitative study to gain understanding from patients and GPS (2019)
Journal Article
Jefferson, L., Atkin, K., Sheridan, R., Oliver, S., Macleod, U., Hall, G., Forbes, S., Green, T., Allgar, V., & Knapp, P. (2019). Non-attendance at urgent referral appointments for suspected cancer: A qualitative study to gain understanding from patients and GPS. The British journal of general practice : the journal of the Royal College of General Practitioners, 69(689), E850-E859. https://doi.org/10.3399/bjgp19X706625

© British Journal of General Practice Background: The 2-week-wait urgent referral policy in the UK has sought to improve cancer outcomes by accelerating diagnosis and treatment. However, around 5-7% of symptomatic referred patients cancel or do not... Read More about Non-attendance at urgent referral appointments for suspected cancer: A qualitative study to gain understanding from patients and GPS.

Perceived colorectal cancer candidacy and the role of candidacy in colorectal cancer screening (2019)
Journal Article
Bikker, A. P., Macdonald, S., Robb, K. A., Conway, E., Browne, S., Campbell, C., Weller, D., Steele, R., & Macleod, U. (2019). Perceived colorectal cancer candidacy and the role of candidacy in colorectal cancer screening. Health, Risk and Society, 21(7-8), 352-372. https://doi.org/10.1080/13698575.2019.1680816

© 2019 Informa UK Limited, trading as Taylor & Francis Group. Screening is a well-established tool to advance earlier cancer diagnosis. We used Davison’s concept of ‘candidacy’ to explore how individuals draw on collectively constructed images of ‘... Read More about Perceived colorectal cancer candidacy and the role of candidacy in colorectal cancer screening.

Physiotherapy outcome measures of haemophilia acute bleed episodes: What matters to patients? (2019)
Journal Article
Bradshaw, E., McClellan, C., Whybrow, P., & Cramp, F. (2019). Physiotherapy outcome measures of haemophilia acute bleed episodes: What matters to patients?. Haemophilia, 25(6), 1066-1072. https://doi.org/10.1111/hae.13840

Introduction The research was conducted at a UK teaching hospital and Haemophilia Comprehensive Care Centre (CCC) as part of a research programme investigating physiotherapy for acute bleed management. Aim The aim of the study was to understand th... Read More about Physiotherapy outcome measures of haemophilia acute bleed episodes: What matters to patients?.

Patient non-attendance at urgent referral appointments for suspected cancer and its links to cancer diagnosis and one year mortality: A cohort study of patients referred on the Two Week Wait pathway (2019)
Journal Article
Sheridan, R., Oliver, S. E., Hall, G., Allgar, V., Melling, P., Bolton, E., Atkin, K., Denton, D., Forbes, S., Green, T., Macleod, U., & Knapp, P. (2019). Patient non-attendance at urgent referral appointments for suspected cancer and its links to cancer diagnosis and one year mortality: A cohort study of patients referred on the Two Week Wait pathway. Cancer epidemiology, 63, Article 101588. https://doi.org/10.1016/j.canep.2019.101588

© 2019 The Authors Background: The ‘Two Week Wait’ policy aims to ensure patients with suspected cancer are seen within two weeks of referral. However, patient non-attendance can result in this target being missed. This study aimed to identify predic... Read More about Patient non-attendance at urgent referral appointments for suspected cancer and its links to cancer diagnosis and one year mortality: A cohort study of patients referred on the Two Week Wait pathway.

An integrated understanding of the complex drivers of emergency presentations and admissions in cancer patients: qualitative modelling of secondary-care health professionals’ experiences and views (2019)
Journal Article
Chen, H., Walabyeki, J., Johnson, M., Boland, E., Seymour, J., & Macleod, U. (2019). An integrated understanding of the complex drivers of emergency presentations and admissions in cancer patients: qualitative modelling of secondary-care health professionals’ experiences and views. PLoS ONE, 14(5), Article e0216430. https://doi.org/10.1371/journal.pone.0216430

The number of cancer-related emergency presentations and admissions has been steadily increasing in the UK. Drivers of this phenomenon are complex, multifactorial and interlinked. The main objective of this study was to understand the complexity of e... Read More about An integrated understanding of the complex drivers of emergency presentations and admissions in cancer patients: qualitative modelling of secondary-care health professionals’ experiences and views.

Facilitated group work for people with long-term conditions: a systematic review of benefits from studies of group-work interventions (2019)
Journal Article
Jackson, M., Jones, D., Dyson, J., & Macleod, U. (2019). Facilitated group work for people with long-term conditions: a systematic review of benefits from studies of group-work interventions. The British journal of general practice : the journal of the Royal College of General Practitioners, 69(682), E363-E372. https://doi.org/10.3399/bjgp19X702233

Background: About 15.4 million people in the UK live with a long-term condition. Of the health and social care spend, 70% is invested in caring for this population. Evidence suggests that group-work interventions offer patient support, improved outco... Read More about Facilitated group work for people with long-term conditions: a systematic review of benefits from studies of group-work interventions.