All Outputs (42)

Identification of survivin as a promising target for the immunotherapy of adult B-cell acute lymphoblastic leukemia (2017)
Journal Article
Boullosa, L. F., Savaliya, P., Bonney, S., Orchard, L., Wickenden, H., Lee, C., …Guinn, B. A. (2018). Identification of survivin as a promising target for the immunotherapy of adult B-cell acute lymphoblastic leukemia. Oncotarget, 9(3), 3853-3866. https://doi.org/10.18632/oncotarget.23380

B-cell acute lymphoblastic leukemia (B-ALL) is a rare heterogeneous disease characterized by a block in lymphoid differentiation and a rapid clonal expansion of immature, non-functioning B cells. Adult B-ALL patients have a poor prognosis with less t... Read More about Identification of survivin as a promising target for the immunotherapy of adult B-cell acute lymphoblastic leukemia.

ORAI channels are critical for receptor-mediated endocytosis of albumin (2017)
Journal Article
Zeng, B., Chen, G., Garcia-Vaz, E., Bhandari, S., Daskoulidou, N., Berglund, L. M., …Xu, S. (2017). ORAI channels are critical for receptor-mediated endocytosis of albumin. Nature communications, 8(1), Article 1920. https://doi.org/10.1038/s41467-017-02094-y

Impaired albumin reabsorption by proximal tubular epithelial cells (PTECs) has been highlighted in diabetic nephropathy (DN), but little is known about the underlying molecular mechanisms. Here we find that ORAI1-3, are preferentially expressed in PT... Read More about ORAI channels are critical for receptor-mediated endocytosis of albumin.

Lck is a relevant target in chronic lymphocytic leukaemia cells whose expression variance is unrelated to disease outcome (2017)
Journal Article
Till, K. J., Allen, J. C., Talab, F., Lin, K., Allsup, D., Cawkwell, L., …Slupsky, J. R. (2017). Lck is a relevant target in chronic lymphocytic leukaemia cells whose expression variance is unrelated to disease outcome. Scientific reports, 7(1), Article ARTN 16784. https://doi.org/10.1038/s41598-017-17021-w

© 2017 The Author(s). Pathogenesis of chronic lymphocytic leukaemia (CLL) is contingent upon antigen receptor (BCR) expressed by malignant cells of this disease. Studies on somatic hypermutation of the antigen binding region, receptor expression leve... Read More about Lck is a relevant target in chronic lymphocytic leukaemia cells whose expression variance is unrelated to disease outcome.

Differing mechanisms of thrombin generation in live haematological and solid cancer cells determined by calibrated automated thrombography (2017)
Journal Article
Adesanya, M. A., Maraveyas, A., & Madden, L. (2017). Differing mechanisms of thrombin generation in live haematological and solid cancer cells determined by calibrated automated thrombography. Blood Coagulation and Fibrinolysis, 28(8), 602-611. https://doi.org/10.1097/mbc.0000000000000644

© 2017 Wolters Kluwer Health, Inc. All rights reserved. Calibrated automated thrombography (CAT) is emerging as a reliable tool for real-Time estimation of thrombin generation potential. There is a clinical need for knowledge about the pathways under... Read More about Differing mechanisms of thrombin generation in live haematological and solid cancer cells determined by calibrated automated thrombography.

Investigation of the filamin A-Dependent mechanisms of tissue factor incorporation into microvesicles (2017)
Journal Article
Collier, M. E. W., Ettelaie, C., Goult, B. T., Maraveyas, A., & Goodall, A. H. (2017). Investigation of the filamin A-Dependent mechanisms of tissue factor incorporation into microvesicles. Thrombosis and haemostasis, 117(11), 2034-2044. https://doi.org/10.1160/TH17-01-0009

We have previously shown that phosphorylation of tissue factor (TF) at Ser253 increases the incorporation of TF into microvesicles (MVs) following protease-activated receptor 2 (PAR2) activation through a process involving filamin-A, whereas Ser258 p... Read More about Investigation of the filamin A-Dependent mechanisms of tissue factor incorporation into microvesicles.

Amino acid based gallium-68 chelators capable of radiolabeling at neutral pH (2017)
Journal Article
Kubicek, V., Bohmova, Z., Price, T. W., Gallo, J., Kubíček, V., Böhmová, Z., …Stasiuk, G. J. (2017). Amino acid based gallium-68 chelators capable of radiolabeling at neutral pH. Dalton Transactions : an international journal of inorganic chemistry, 46(48), 16973-16982. https://doi.org/10.1039/c7dt03398b

Gallium-68 ( 68 Ga) has been the subject of increasing interest for its potential in the production of radiotracers for diagnosis of diseases. In this work we report the complexation of 68 Ga by the amino acid based tripodal chelate H 3 Dpaa, and two... Read More about Amino acid based gallium-68 chelators capable of radiolabeling at neutral pH.

Tissue factor-bearing microparticles and inflammation: a potential mechanism for the development of venous thromboembolism in cancer (2017)
Journal Article
Date, K., Ettelaie, C., & Maraveyas, A. (2017). Tissue factor-bearing microparticles and inflammation: a potential mechanism for the development of venous thromboembolism in cancer. Journal of thrombosis and haemostasis : JTH, 15(12), 2289-2299. https://doi.org/10.1111/jth.13871

© 2017 International Society on Thrombosis and Haemostasis Summary: Cancer is associated with an increased risk of venous thromboembolism (VTE); the exact mechanisms for the induction of VTE remain to be fully elucidated, but it is widely acknowledge... Read More about Tissue factor-bearing microparticles and inflammation: a potential mechanism for the development of venous thromboembolism in cancer.

The HF-CGM study: An analysis of cardiogoniometric axes in patients with cardiac resynchronization therapy (2017)
Journal Article
Clark, A. L., Hoye, A., Beddoes, G., Nikolaidou, T., & Brown, O. I. (2018). The HF-CGM study: An analysis of cardiogoniometric axes in patients with cardiac resynchronization therapy. IEEE transactions on bio-medical engineering / Bio-medical Engineering Group, 65(8), 1711-1716. https://doi.org/10.1109/TBME.2017.2769060

Goal: The HF-CGM is a proof-of-principle study to investigate whether cardiogoniometry (CGM), a three-dimensional electrocardiographic method, can differentiate between pacing modes in patients with cardiac resynchronization therapy (CRT). Methods: A... Read More about The HF-CGM study: An analysis of cardiogoniometric axes in patients with cardiac resynchronization therapy.

The Role of Chemokines in Thyroid Carcinoma (2017)
Journal Article
Yapa, S., Mulla, O., Green, V., England, J., & Greenman, J. (2017). The Role of Chemokines in Thyroid Carcinoma. Thyroid : official journal of the American Thyroid Association, 27(11), 1347-1359. https://doi.org/10.1089/thy.2016.0660

© Copyright 2017, Mary Ann Liebert, Inc. 2017. The global incidence of thyroid cancer is increasing, and metastatic spread to the lymph nodes is common in papillary thyroid carcinoma. The metastatic course of thyroid carcinoma is an intricate process... Read More about The Role of Chemokines in Thyroid Carcinoma.

Peptidyl-prolyl isomerase 1 (Pin1) preserves the phosphorylation state of tissue factor and prolongs its release within microvesicles (2017)
Journal Article
Ettelaie, C., Collier, M., Featherby, S., Greenman, J., & Maraveyas, A. (2018). Peptidyl-prolyl isomerase 1 (Pin1) preserves the phosphorylation state of tissue factor and prolongs its release within microvesicles. BBA - Molecular Cell Research, 1865(1), 12-24. https://doi.org/10.1016/j.bbamcr.2017.09.016

© 2017 Elsevier B.V. The exposure and release of TF is regulated by post-translational modifications of its cytoplasmic domain. Here, the potential of Pin1 to interact with the cytoplasmic domain of TF, and the outcome on TF function was examined. MD... Read More about Peptidyl-prolyl isomerase 1 (Pin1) preserves the phosphorylation state of tissue factor and prolongs its release within microvesicles.

Measuring the response of human head and neck squamous cell carcinoma to irradiation in a microfluidic model allowing customized therapy (2017)
Journal Article
Cheah, R., Srivastava, R., Stafford, N. D., Beavis, A. W., Green, V., & Greenman, J. (2017). Measuring the response of human head and neck squamous cell carcinoma to irradiation in a microfluidic model allowing customized therapy. International Journal of Oncology, 51(4), 1227-1238. https://doi.org/10.3892/ijo.2017.4118

Radiotherapy is the standard treatment for head and neck squamous cell carcinoma (HNSCC), however, radioresistance remains a major clinical problem despite significant improvements in treatment protocols. Therapeutic outcome could potentially be impr... Read More about Measuring the response of human head and neck squamous cell carcinoma to irradiation in a microfluidic model allowing customized therapy.

Effect of metabolic status on conceptus–maternal interactions on day 19 in dairy cattle: II. Effects on the endometrial transcriptome (2017)
Journal Article
Bauersachs, S., Simintiras, C. A., Sturmey, R. G., Krebs, S., Bick, J., Blum, H., …Forde, N. (2017). Effect of metabolic status on conceptus–maternal interactions on day 19 in dairy cattle: II. Effects on the endometrial transcriptome. Biology of Reproduction, 97(3), 413-425. https://doi.org/10.1093/biolre/iox095

The aim of this study was to test the hypothesis that the metabolic stresses associated with lactation alter the ability of the endometrium to respond appropriately to the conceptus by examining endometrial gene expression on Day 19 of pregnancy. Imm... Read More about Effect of metabolic status on conceptus–maternal interactions on day 19 in dairy cattle: II. Effects on the endometrial transcriptome.

The use of ofatumumab in the treatment of B-cell malignancies (2017)
Journal Article
Soe, Z. N., & Allsup, D. (2017). The use of ofatumumab in the treatment of B-cell malignancies. Future oncology, 13(29), 2611-2628. https://doi.org/10.2217/fon-2017-0275

Ofatumumab has been extensively studied in the treatment of B-cell malignancies. Currently, it has been approved for the treatment of chronic lymphocytic leukemia in a number of different situations. However, there is still no compelling evidence con... Read More about The use of ofatumumab in the treatment of B-cell malignancies.

Assessment of ibrutinib plus rituximab in front-line CLL (FLAIR trial): study protocol for a phase III randomised controlled trial (2017)
Journal Article
Collett, L., Howard, D. R., Munir, T., McParland, L., Oughton, J. B., Rawstron, A. C., …Hillmen, P. (2017). Assessment of ibrutinib plus rituximab in front-line CLL (FLAIR trial): study protocol for a phase III randomised controlled trial. Trials, 18(1), Article 387. https://doi.org/10.1186/s13063-017-2138-6

Background Treatment of chronic lymphocytic leukaemia (CLL) has seen a substantial improvement over the last few years. Combination immunochemotherapy, such as fludarabine, cyclophosphamide and rituximab (FCR), is now standard first-line therapy. How... Read More about Assessment of ibrutinib plus rituximab in front-line CLL (FLAIR trial): study protocol for a phase III randomised controlled trial.

Animals can assign novel odours to a known category (2017)
Journal Article
Wright, H. F., Wilkinson, A., Croxton, R. S., Graham, D. K., Harding, R. C., Hodkinson, H. L., …Zulch, H. E. (2017). Animals can assign novel odours to a known category. Scientific reports, 7(1), Article 9019. https://doi.org/10.1038/s41598-017-09454-0

The ability to identify a novel stimulus as a member of a known category allows an organism to respond appropriately towards it. Categorisation is thus a fundamental component of cognition and an essential tool for processing and responding to unkn... Read More about Animals can assign novel odours to a known category.

A microfluidic device for rapid screening of E. coli O157:H7 based on IFAST and ATP bioluminescence assay for water analysis (2017)
Journal Article
Ngamsom, B., Truyts, A., Fourie, L., Kumar, S., Tarn, M. D., Iles, A., …Pamme, N. (2017). A microfluidic device for rapid screening of E. coli O157:H7 based on IFAST and ATP bioluminescence assay for water analysis. Chemistry: a European journal, 23(52), 12754-12757. https://doi.org/10.1002/chem.201703487

© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim We present a simple microfluidic system for rapid screening of Escherichia coli (E. coli) O157:H7 employing the specificity of immunomagnetic separation (IMS) via immiscible filtration assisted by s... Read More about A microfluidic device for rapid screening of E. coli O157:H7 based on IFAST and ATP bioluminescence assay for water analysis.

Do sodium channel proteolytic fragments regulate sodium channel expression? (2017)
Journal Article
Onwuli, D. O., Yañez-Bisbe, L., Pinsach-Abuin, M., Tarradas, A., Brugada, R., Greenman, J., …Beltran-Alvarez, P. (2017). Do sodium channel proteolytic fragments regulate sodium channel expression?. Channels, 11(5), 476-481. https://doi.org/10.1080/19336950.2017.1355663

© 2017 Taylor & Francis The cardiac voltage-gated sodium channel (gene: SCN5A, protein: Na V 1.5) is responsible for the sodium current that initiates the cardiomyocyte action potential. Research into the mechanisms of SCN5A gene expression has gai... Read More about Do sodium channel proteolytic fragments regulate sodium channel expression?.

Cancer microvesicles induce tissue factor-related procoagulant activity in endothelial cells in vitro (2017)
Journal Article
Adesanya, M. A., Maraveyas, A., & Madden, L. A. (2017). Cancer microvesicles induce tissue factor-related procoagulant activity in endothelial cells in vitro. Blood Coagulation and Fibrinolysis, 28(5), 365-372. https://doi.org/10.1097/MBC.0000000000000607

Copyright © 2017 Wolters Kluwer Health, Inc. All rights reserved. Microvesicles associated with tissue factor (TF) may play a role in cancer-related venous thromboembolism; however, not much is known about their interaction with the tumour stroma, es... Read More about Cancer microvesicles induce tissue factor-related procoagulant activity in endothelial cells in vitro.

The detrimental impact of extracellular bacterial proteases on wound healing (2017)
Journal Article
Lindsay, S., Oates, A., & Bourdillon, K. (2017). The detrimental impact of extracellular bacterial proteases on wound healing. International wound journal, 14(6), 1237-1247. https://doi.org/10.1111/iwj.12790

In addition to clinical signs of infection (e.g. inflammation, purulence and pain), a microbial count of ≥105 colony‐forming units/g has historically been used to define wound infection. However, it is increasingly recognised that, rather than a high... Read More about The detrimental impact of extracellular bacterial proteases on wound healing.

cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway (2017)
Journal Article
Aburima, A., Walladbegi, K., Wake, J. D., & Naseem, K. M. (2017). cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway. Journal of thrombosis and haemostasis : JTH, 15(8), 1668-1678. https://doi.org/10.1111/jth.13738

Essentials Platelet shape change requires cytoskeletal rearrangement via myosin‐mediated actin contraction. We investigated whether nitric oxide (NO) affected thrombin‐induced platelet shape change. NO inhibits shape change, RhoA/ROCK signalling a... Read More about cGMP signaling inhibits platelet shape change through regulation of the RhoA-Rho Kinase-MLC phosphatase signaling pathway.