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The detrimental impact of extracellular bacterial proteases on wound healing

Lindsay, Sharon; Oates, Angela; Bourdillon, Katie

Authors

Sharon Lindsay

Angela Oates

Katie Bourdillon



Abstract

In addition to clinical signs of infection (e.g. inflammation, purulence and pain), a microbial count of ≥105 colony‐forming units/g has historically been used to define wound infection. However, it is increasingly recognised that, rather than a high bioburden level alone being detrimental to wound healing, it is the virulence of the invading microorganism and the host's immune status that can affect clinical outcomes. Bacteria, such as Pseudomonas aeruginosa, Staphylococcus aureus and Staphylococcus epidermidis, have developed a range of virulence factors to help them overcome host defences and proliferate within the underlying soft tissue. More specifically, bacterial proteases are one such virulence factor that has been implicated in promoting the invasion and destruction of the host tissue. Because of the complexities of microorganisms, the proteases can negatively impact the wound environment, leading to delayed wound healing. The aim of the present paper is to describe various extracellular bacterial proteases; review the impact they have on the wound environment, the host immune response and biofilms; and discuss potential wound management strategies against them. The evidence discussed suggests that proteases may play a profound role in wound infections, contribute to the development of an inflammatory response and impede wound healing.

Citation

Lindsay, S., Oates, A., & Bourdillon, K. (2017). The detrimental impact of extracellular bacterial proteases on wound healing. International wound journal, 14(6), 1237-1247. https://doi.org/10.1111/iwj.12790

Journal Article Type Article
Acceptance Date Jun 15, 2017
Online Publication Date Jul 25, 2017
Publication Date 2017-12
Deposit Date Jan 15, 2019
Publicly Available Date Jan 16, 2019
Journal International Wound Journal
Print ISSN 1742-4801
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 14
Issue 6
Pages 1237-1247
DOI https://doi.org/10.1111/iwj.12790
Keywords Bacterial protease; Point-of-care diagnostic; Virulence factor; Wound infection
Public URL https://hull-repository.worktribe.com/output/1215878
Publisher URL https://onlinelibrary.wiley.com/doi/full/10.1111/iwj.12790
Related Public URLs http://eprints.whiterose.ac.uk/122599/1/Microbial%20protease%20review%20paper%20FINAL.pdf
Contract Date Jan 16, 2019

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