MRC2
(2012)
Book Chapter
Gronau, J. H., Isacke, C. M., & Sturge, J. (2012). MRC2. In S. Choi (Ed.), Encyclopedia of Signaling Molecules (1119-1123). Springer. https://doi.org/10.1007/978-1-4419-0461-4_79
All Outputs (43)
Expression and localization of creatine kinase in the preimplantation embryo (2012)
Journal Article
Forsey, K. E., Ellis, P. J., Sargent, C. A., Sturmey, R. G., & Leese, H. J. (2013). Expression and localization of creatine kinase in the preimplantation embryo. Molecular Reproduction and Development, 80(3), 185-192. https://doi.org/10.1002/mrd.22146Creatine Kinase (CK) catalyses the “creatine shuttle,” the reversible conversion of creatine phosphate to creatine with the liberation of ATP. This article examines the potential role of the creatine shuttle in the provision of ATP during mouse preim... Read More about Expression and localization of creatine kinase in the preimplantation embryo.
Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny (2012)
Journal Article
Calaminus, S. D. J., Guitart, A., Sinclair, A., Schachtner, H., Watson, S. P., Holyoake, T. L., Kranc, K. R., & Machesky, L. M. (2012). Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny. PLoS ONE, 7(12), e51361. https://doi.org/10.1371/journal.pone.0051361The development of a megakaryocyte lineage specific Cre deleter, using the Pf4 (CXCL4) promoter (Pf4-Cre), was a significant step forward in the specific analysis of platelet and megakaryocyte cell biology. However, in the present study we have emplo... Read More about Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny.
Endo180 modulation by bisphosphonates and diagnostic accuracy in metastatic breast cancer (2012)
Journal Article
Palmieri, C., Caley, M. P., Purshouse, K., Fonseca, A.-V., Rodriguez-Teja, M., Kogianni, G., Woodley, L., Odendaal, J., Elliott, K., Waxman, J., & Sturge, J. (2013). Endo180 modulation by bisphosphonates and diagnostic accuracy in metastatic breast cancer. The British Journal of Cancer, 108(1), 163-169. https://doi.org/10.1038/bjc.2012.540Background:Endo180 (CD280; MRC2; uPARAP)-dependent collagen remodelling is dysregulated in primary tumours and bone metastasis. Here, we confirm the release and diagnostic accuracy of soluble Endo180 for diagnosing metastasis in breast cancer (BCa).M... Read More about Endo180 modulation by bisphosphonates and diagnostic accuracy in metastatic breast cancer.
Abstract P2-02-03: the collagen receptor Endo180: a metastatic plasma marker in breast cancer modulated by bisphosphonate treatment (2012)
Presentation / Conference Contribution
Sturge, J., Caley, M., Purshouse, K., Fonseca, A.-V., Rodriguez-Teja, M., Kogianni, G., Waxman, J., & Palmieri, C. (2012, December). Abstract P2-02-03: the collagen receptor Endo180: a metastatic plasma marker in breast cancer modulated by bisphosphonate treatment. Presented at Abstracts: Thirty-Fifth Annual CTRC‐AACR San Antonio Breast Cancer Symposium‐‐ Dec 4‐8, 2012; San Antonio, TX
PTEN protein expression in malignant pleural mesothelioma (2012)
Journal Article
Agarwal, V., Campbell, A., Beaumont, K. L., Cawkwell, L., & Lind, M. J. (2013). PTEN protein expression in malignant pleural mesothelioma. Tumor Biology, 34(2), 847-851. https://doi.org/10.1007/s13277-012-0615-9Malignant pleural mesothelioma is associated with poor prognosis and despite recent advances in chemotherapy, the median survival is still approximately 12 months. Loss of phosphatase and tensin homolog (PTEN) protein expression may lead to constitut... Read More about PTEN protein expression in malignant pleural mesothelioma.
Pulsed extremely low-frequency magnetic fields stimulate microvesicle release from human monocytic leukaemia cells (2012)
Journal Article
Stratton, D., Lange, S., & Inal, J. M. (2013). Pulsed extremely low-frequency magnetic fields stimulate microvesicle release from human monocytic leukaemia cells. Biochemical and biophysical research communications, 430(2), 470-475. https://doi.org/10.1016/j.bbrc.2012.12.012Microvesicles are released from cell surfaces constitutively during early apoptosis or upon activation with various stimuli including sublytic membrane attack complex (MAC). This study shows that an alternating current, pulsed, extremely low-frequenc... Read More about Pulsed extremely low-frequency magnetic fields stimulate microvesicle release from human monocytic leukaemia cells.
Enhanced binding of tissue factor-microparticles to collagen-IV and fibronectin leads to increased tissue factor activity in vitro (2012)
Journal Article
Ettelaie, C., Collier, M. E. W., Mei, M. P., Xiao, Y. P., & Maraveyas, A. (2013). Enhanced binding of tissue factor-microparticles to collagen-IV and fibronectin leads to increased tissue factor activity in vitro. Thrombosis and haemostasis, 109(1), 61-71. https://doi.org/10.1160/TH12-05-0279The role of tissue factor (TF)-containing microparticles in clot propagation has been established, but the ability of circulating microparticles to initiate coagulation has been disputed. However, TF-bearing microparticles, particularly endothelial-m... Read More about Enhanced binding of tissue factor-microparticles to collagen-IV and fibronectin leads to increased tissue factor activity in vitro.
Food restriction reverses the hyper-muscular phenotype and force generation capacity deficit of the myostatin null mouse (2012)
Journal Article
Matsakas, A., Romanello, V., Sartori, R., Masiero, E., Macharia, R., Otto, A., Elashry, M., Sandri, M., & Patel, K. (2013). Food restriction reverses the hyper-muscular phenotype and force generation capacity deficit of the myostatin null mouse. International journal of sports medicine, 34(3), 223-231. https://doi.org/10.1055/s-0032-1312605Food restriction has a great impact on skeletal muscle mass by inducing muscle protein breakdown to provide substrates for energy production through gluconeogenesis. Genetic models of hyper-muscularity interfere with the normal balance between protei... Read More about Food restriction reverses the hyper-muscular phenotype and force generation capacity deficit of the myostatin null mouse.
Oocyte developmental failure in response to elevated nonesterified fatty acid concentrations: mechanistic insights (2012)
Journal Article
Van Hoeck, V., Leroy, J. L. M. R., Arias Alvarez, M., Rizos, D., Gutierrez-Adan, A., Schnorbusch, K., Bols, P. E. J., Leese, H. J., & Sturmey, R. G. (2013). Oocyte developmental failure in response to elevated nonesterified fatty acid concentrations: mechanistic insights. Reproduction, 145(1), 33-44. https://doi.org/10.1530/REP-12-0174Elevated plasma nonesterified fatty acid (NEFA) concentrations are associated with negative energy balance and metabolic disorders such as obesity and type II diabetes. Such increased plasma NEFA concentrations induce changes in the microenvironment... Read More about Oocyte developmental failure in response to elevated nonesterified fatty acid concentrations: mechanistic insights.
Actin on trafficking: could actin guide directed receptor transport? (2012)
Journal Article
Zech, T., Calaminus, S. D., & Machesky, L. M. (2012). Actin on trafficking: could actin guide directed receptor transport?. Cell adhesion & migration, 6(6), 476-481. https://doi.org/10.4161/cam.21373Here, we present emerging ideas surrounding the interplay between the actin cytoskeleton and receptor transport and activation. The bulk of actin dynamics in cells is thought to contribute to architecture and mobility. Actin also contributes to traff... Read More about Actin on trafficking: could actin guide directed receptor transport?.
Functional characterization of TbMCP5, a conserved and essential ADP/ATP carrier present in the mitochondrion of the human pathogen Trypanosoma brucei (2012)
Journal Article
Peña-Diaz, P., Pelosi, L., Ebikeme, C., Colasante, C., Gao, F., Bringaud, F., & Voncken, F. (2012). Functional characterization of TbMCP5, a conserved and essential ADP/ATP carrier present in the mitochondrion of the human pathogen Trypanosoma brucei. Journal of Biological Chemistry, 287(50), 41861-41874. https://doi.org/10.1074/jbc.M112.404699Trypanosoma brucei is a kinetoplastid parasite of medical and veterinary importance. Its digenetic life cycle alternates between the bloodstream form in the mammalian host and the procyclic form (PCF) in the bloodsucking insect vector, the tsetse fly... Read More about Functional characterization of TbMCP5, a conserved and essential ADP/ATP carrier present in the mitochondrion of the human pathogen Trypanosoma brucei.
Analysis of amino acids in latent fingerprint residue by capillary electrophoresis-mass spectrometry: Other Techniques (2012)
Journal Article
Atherton, T., Croxton, R., Baron, M., Gonzalez-Rodriguez, J., Gámiz-Gracia, L., & García-Campaña, A. M. (2012). Analysis of amino acids in latent fingerprint residue by capillary electrophoresis-mass spectrometry: Other Techniques. Journal of Separation Science, 35(21), 2994-2999. https://doi.org/10.1002/jssc.201200398The analysis of the chemical composition of fingerprints is important for the development and improvement of existing fingerprint enhancement techniques. This study demonstrates the first analysis of a latent fingerprint sample, using an optimized CE... Read More about Analysis of amino acids in latent fingerprint residue by capillary electrophoresis-mass spectrometry: Other Techniques.
Chemical Characterization of Latent Fingerprints by Matrix-Assisted Laser Desorption Ionization, Time-of-Flight Secondary Ion Mass Spectrometry, Mega Electron Volt Secondary Mass Spectrometry, Gas Chromatography/Mass Spectrometry, X-ray Photoelectron Spectroscopy, and Attenuated Total Reflection Fourier Transform Infrared Spectroscopic Imaging: An Intercomparison (2012)
Journal Article
Bailey, M. J., Bright, N. J., Croxton, R. S., Francese, S., Ferguson, L. S., Hinder, S., …Bleay, S. (2012). Chemical Characterization of Latent Fingerprints by Matrix-Assisted Laser Desorption Ionization, Time-of-Flight Secondary Ion Mass Spectrometry, Mega Electron Volt Secondary Mass Spectrometry, Gas Chromatography/Mass Spectrometry, X-ray Photoelectron Spectroscopy, and Attenuated Total Reflection Fourier Transform Infrared Spectroscopic Imaging: An Intercomparison. Analytical chemistry, 84(20), 8514-8523. https://doi.org/10.1021/ac302441yThe first analytical intercomparison of fingerprint residue using equivalent samples of latent fingerprint residue and characterized by a suite of relevant techniques is presented. This work has never been undertaken, presumably due to the perishable... Read More about Chemical Characterization of Latent Fingerprints by Matrix-Assisted Laser Desorption Ionization, Time-of-Flight Secondary Ion Mass Spectrometry, Mega Electron Volt Secondary Mass Spectrometry, Gas Chromatography/Mass Spectrometry, X-ray Photoelectron Spectroscopy, and Attenuated Total Reflection Fourier Transform Infrared Spectroscopic Imaging: An Intercomparison.
Students' perception of biology fieldwork : the example of students undertaking a preliminary year at a UK university (2012)
Journal Article
Goulder, R., Scott, G., & Scott, L. J. (2013). Students' perception of biology fieldwork : the example of students undertaking a preliminary year at a UK university. International journal of science education, 35(8), 1385-1406. https://doi.org/10.1080/09500693.2012.708796It is widely held among biology teachers that fieldwork is valuable, but little is heard about students' perception of fieldwork or about the reasons for their liking or disliking fieldwork. This paper uses data from students to explore the hypothese... Read More about Students' perception of biology fieldwork : the example of students undertaking a preliminary year at a UK university.
Store-independent pathways for cytosolic STIM1 clustering in the regulation of store-operated Ca2+ influx (2012)
Journal Article
Zeng, B., Chen, G.-L., & Xu, S. Z. (2012). Store-independent pathways for cytosolic STIM1 clustering in the regulation of store-operated Ca2+ influx. Biochemical Pharmacology, 84(8), 1024-1035. https://doi.org/10.1016/j.bcp.2012.07.013STIM1 is a Ca 2+ sensing molecule. Once the Ca 2+ stores are depleted, STIM1 moves towards the plasma membrane (PM) (translocation), forms puncta (clustering), and triggers store-operated Ca 2+ entry (SOCE). Although this process has been regarded as... Read More about Store-independent pathways for cytosolic STIM1 clustering in the regulation of store-operated Ca2+ influx.
CXCR4 chemokine receptor antagonists: nickel(II) complexes of configurationally restricted macrocycles (2012)
Journal Article
Smith, R., Huskens, D., Daelemans, D., Mewis, R. E., Garcia, C. D., Cain, A. N., Freeman, T. N. C., Pannecouque, C., Clercq, E. D., Schols, D., Hubin, T. J., & Archibald, S. J. (2012). CXCR4 chemokine receptor antagonists: nickel(II) complexes of configurationally restricted macrocycles. Dalton Transactions : an international journal of inorganic chemistry, 41(37), 11369-11377. https://doi.org/10.1039/c2dt31137bTetraazamacrocyclic complexes of transition metals provide useful units for incorporating multiple coordination interactions into a single protein binding molecule. They can be designed with available sites for protein interactions via donor atom-con... Read More about CXCR4 chemokine receptor antagonists: nickel(II) complexes of configurationally restricted macrocycles.
Variable imprinting of the MEST gene in human preimplantation embryos (2012)
Journal Article
Huntriss, J. D., Hemmings, K. E., Hinkins, M., Rutherford, A. J., Sturmey, R. G., Elder, K., & Picton, H. M. (2013). Variable imprinting of the MEST gene in human preimplantation embryos. European Journal of Human Genetics, 21(1), 40-47. https://doi.org/10.1038/ejhg.2012.102There is evidence that expression and methylation of the imprinted paternally expressed gene 1/mesoderm-specific transcript homologue (PEG1/MEST) gene may be affected by assisted reproductive technologies (ARTs) and infertility. In this study, we sou... Read More about Variable imprinting of the MEST gene in human preimplantation embryos.
Targeting radiation-resistant hypoxic tumour cells through ATR inhibition (2012)
Journal Article
Monteiro dos Santos Pires, I., Olcina, M. M., Anbalagan, S., Pollard, J. R., Reaper, P. M., Charlton, P. A., McKenna, W. G., & Hammond, E. M. (2012). Targeting radiation-resistant hypoxic tumour cells through ATR inhibition. The British Journal of Cancer, 107(2), 291-299. https://doi.org/10.1038/bjc.2012.265Background:Most solid tumours contain regions of sub-optimal oxygen concentration (hypoxia). Hypoxic cancer cells are more resistant to radiotherapy and represent the most aggressive fraction of a tumour. It is therefore essential that strategies con... Read More about Targeting radiation-resistant hypoxic tumour cells through ATR inhibition.
MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein (2012)
Journal Article
Schenková, K., Lutz, J., Kopp, M., Ramos, S., & Rivero, F. (2012). MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein. Journal of Molecular Biology, 422(5), 659-673. https://doi.org/10.1016/j.jmb.2012.06.016RhoBTB (BTB stands for broad-complex, tramtrack, bric à brac) proteins are tumor suppressors involved in the formation of cullin 3 (Cul3)-dependent ubiquitin ligase complexes. However, no substrates of RhoBTB-Cul3 ubiquitin ligase complexes have been... Read More about MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein.