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Actin on trafficking: could actin guide directed receptor transport?

Calaminus, Simon D J; Calaminus, Simon D. J.; Calaminus, Simon; Zech, Tobias; Calaminus, Simon D.J.; Machesky, Laura M.


Simon D J Calaminus

Simon D. J. Calaminus

Simon Calaminus

Tobias Zech

Simon D.J. Calaminus

Laura M. Machesky


Here, we present emerging ideas surrounding the interplay between the actin cytoskeleton and receptor transport and activation. The bulk of actin dynamics in cells is thought to contribute to architecture and mobility. Actin also contributes to trafficking, acting as a molecular scaffold, providing force to deform membranes, facilitating vesicle abscission or propelling a vesicle through the cytoplasm1,2 and recent studies highlight important connections between the directed trafficking of receptors and the impact on cell migration and actin dynamics. Additionally, a number of newly described actin nucleation promoting factors, such as the vesicle associated protein WASH, reveal unexpected roles of actin in membrane traffic and suggest that the cell dedicates a significant proportion of its regulation of actin dynamics to controlling trafficking.


Zech, T., Calaminus, S. D., & Machesky, L. M. (2012). Actin on trafficking: could actin guide directed receptor transport?. Cell adhesion & migration, 6(6), (476-481). doi:10.4161/cam.21373. ISSN 1933-6918

Journal Article Type Commentary
Acceptance Date Jul 5, 2012
Online Publication Date Oct 17, 2012
Publication Date Nov 17, 2012
Print ISSN 1933-6918
Electronic ISSN 1933-6926
Publisher Taylor & Francis
Peer Reviewed Peer Reviewed
Volume 6
Issue 6
Pages 476-481
Keywords trafficking, endosomes, receptor trafficking, exocytosis, WASP family proteins, Arp 2/3 complex
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