Simon D J Calaminus
Actin on trafficking: could actin guide directed receptor transport?
Calaminus, Simon D J; Calaminus, Simon D. J.; Calaminus, Simon; Zech, Tobias; Calaminus, Simon D.J.; Machesky, Laura M.
Authors
Simon D. J. Calaminus
Dr Simon Calaminus S.Calaminus@hull.ac.uk
Tobias Zech
Dr Simon Calaminus S.Calaminus@hull.ac.uk
Laura M. Machesky
Abstract
Here, we present emerging ideas surrounding the interplay between the actin cytoskeleton and receptor transport and activation. The bulk of actin dynamics in cells is thought to contribute to architecture and mobility. Actin also contributes to trafficking, acting as a molecular scaffold, providing force to deform membranes, facilitating vesicle abscission or propelling a vesicle through the cytoplasm1,2 and recent studies highlight important connections between the directed trafficking of receptors and the impact on cell migration and actin dynamics. Additionally, a number of newly described actin nucleation promoting factors, such as the vesicle associated protein WASH, reveal unexpected roles of actin in membrane traffic and suggest that the cell dedicates a significant proportion of its regulation of actin dynamics to controlling trafficking.
Citation
Zech, T., Calaminus, S. D., & Machesky, L. M. (2012). Actin on trafficking: could actin guide directed receptor transport?. Cell adhesion & migration, 6(6), 476-481. https://doi.org/10.4161/cam.21373
Journal Article Type | Commentary |
---|---|
Acceptance Date | Jul 5, 2012 |
Online Publication Date | Oct 17, 2012 |
Publication Date | Nov 17, 2012 |
Print ISSN | 1933-6918 |
Electronic ISSN | 1933-6926 |
Publisher | Taylor and Francis |
Peer Reviewed | Peer Reviewed |
Volume | 6 |
Issue | 6 |
Pages | 476-481 |
DOI | https://doi.org/10.4161/cam.21373 |
Keywords | trafficking, endosomes, receptor trafficking, exocytosis, WASP family proteins, Arp 2/3 complex |
Public URL | https://hull-repository.worktribe.com/output/428944 |
You might also like
Impact of Surface Ligand on the Biocompatibility of InP/ZnS Quantum Dots with Platelets
(2023)
Journal Article
Platelet zinc status regulates prostaglandin-induced signaling, altering thrombus formation
(2023)
Journal Article
Should aspirin be replaced with ADP blockers or anti-GPVI to manage thrombosis?
(2022)
Journal Article
NIR-quantum dots in biomedical imaging and their future
(2021)
Journal Article
Methods to study the roles of Rho GTPases in platelet function
(2018)
Journal Article
Downloadable Citations
About Repository@Hull
Administrator e-mail: repository@hull.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search